Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis
It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain. We report a "nested" case-control comparison within a prospective study in Reykjavik, I...
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| description | It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain.
We report a "nested" case-control comparison within a prospective study in Reykjavik, Iceland, using baseline values of serum uric acid in 2,456 incident CHD cases and in 3,962 age- and sex-matched controls, plus paired serum uric acid measurements taken at baseline and, on average, 12 y later in 379 participants. In addition, we conducted a meta-analysis of 15 other prospective studies in eight countries conducted in essentially general populations. Compared with individuals in the bottom third of baseline measurements of serum uric acid in the Reykjavik study, those in the top third had an age- and sex-adjusted odds ratio for CHD of 1.39 (95% confidence interval [CI], 1.23-1.58) which fell to 1.12 (CI, 0.97-1.30) after adjustment for smoking and other established risk factors. Overall, in a combined analysis of 9,458 cases and 155,084 controls in all 16 relevant prospective studies, the odds ratio was 1.13 (CI, 1.07-1.20), but it was only 1.02 (CI, 0.91-1.14) in the eight studies with more complete adjustment for possible confounders.
Measurement of serum uric acid levels is unlikely to enhance usefully the prediction of CHD, and this factor is unlikely to be a major determinant of the disease in general populations. |
| doi_str_mv | 10.1371/journal.pmed.0020076 |
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We report a "nested" case-control comparison within a prospective study in Reykjavik, Iceland, using baseline values of serum uric acid in 2,456 incident CHD cases and in 3,962 age- and sex-matched controls, plus paired serum uric acid measurements taken at baseline and, on average, 12 y later in 379 participants. In addition, we conducted a meta-analysis of 15 other prospective studies in eight countries conducted in essentially general populations. Compared with individuals in the bottom third of baseline measurements of serum uric acid in the Reykjavik study, those in the top third had an age- and sex-adjusted odds ratio for CHD of 1.39 (95% confidence interval [CI], 1.23-1.58) which fell to 1.12 (CI, 0.97-1.30) after adjustment for smoking and other established risk factors. Overall, in a combined analysis of 9,458 cases and 155,084 controls in all 16 relevant prospective studies, the odds ratio was 1.13 (CI, 1.07-1.20), but it was only 1.02 (CI, 0.91-1.14) in the eight studies with more complete adjustment for possible confounders.
Measurement of serum uric acid levels is unlikely to enhance usefully the prediction of CHD, and this factor is unlikely to be a major determinant of the disease in general populations.</description><identifier>ISSN: 1549-1676</identifier><identifier>ISSN: 1549-1277</identifier><identifier>EISSN: 1549-1676</identifier><identifier>DOI: 10.1371/journal.pmed.0020076</identifier><identifier>PMID: 15783260</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Biomarkers - blood ; Blood pressure ; Cardiology/Cardiac Surgery ; Cardiovascular disease ; Cardiovascular Medicine ; Case-Control Studies ; Confidence intervals ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - physiopathology ; Epidemiology ; Epidemiology/Public Health ; Female ; Heart attacks ; Humans ; Iceland - epidemiology ; Incidence ; Ischemic heart disease ; Male ; Meta-analysis ; Odds Ratio ; Predictive Value of Tests ; Prospective Studies ; Risk Factors ; Sex Factors ; Systematic reviews and meta-analyses ; Uric acid ; Uric Acid - blood ; Womens health</subject><ispartof>PLoS medicine, 2005-03, Vol.2 (3), p.e76-e76</ispartof><rights>2005 Wheeler. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Citation: Wheeler JG, Juzwishin KDM, Eiriksdottir G, Gudnason V, Danesh J (2005) Serum Uric Acid and Coronary Heart Disease in 9,458 Incident Cases and 155,084 Controls: Prospective Study and Meta-Analysis. PLoS Med 2(3): e76. doi:10.1371/journal.pmed.0020076</rights><rights>Copyright: © 2005 Wheeler. 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-1c1723d3c31e0c4164d67d1f1d0db1c83644964311003f59ddb2007f176246e3</citedby><cites>FETCH-LOGICAL-c590t-1c1723d3c31e0c4164d67d1f1d0db1c83644964311003f59ddb2007f176246e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069667/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1069667/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15783260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Keech, Anthony</contributor><creatorcontrib>Wheeler, Jeremy G</creatorcontrib><creatorcontrib>Juzwishin, Kelsey D M</creatorcontrib><creatorcontrib>Eiriksdottir, Gudny</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Danesh, John</creatorcontrib><title>Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis</title><title>PLoS medicine</title><addtitle>PLoS Med</addtitle><description>It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain.
We report a "nested" case-control comparison within a prospective study in Reykjavik, Iceland, using baseline values of serum uric acid in 2,456 incident CHD cases and in 3,962 age- and sex-matched controls, plus paired serum uric acid measurements taken at baseline and, on average, 12 y later in 379 participants. In addition, we conducted a meta-analysis of 15 other prospective studies in eight countries conducted in essentially general populations. Compared with individuals in the bottom third of baseline measurements of serum uric acid in the Reykjavik study, those in the top third had an age- and sex-adjusted odds ratio for CHD of 1.39 (95% confidence interval [CI], 1.23-1.58) which fell to 1.12 (CI, 0.97-1.30) after adjustment for smoking and other established risk factors. Overall, in a combined analysis of 9,458 cases and 155,084 controls in all 16 relevant prospective studies, the odds ratio was 1.13 (CI, 1.07-1.20), but it was only 1.02 (CI, 0.91-1.14) in the eight studies with more complete adjustment for possible confounders.
Measurement of serum uric acid levels is unlikely to enhance usefully the prediction of CHD, and this factor is unlikely to be a major determinant of the disease in general populations.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Cardiology/Cardiac Surgery</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Medicine</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - physiopathology</subject><subject>Epidemiology</subject><subject>Epidemiology/Public Health</subject><subject>Female</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Iceland - epidemiology</subject><subject>Incidence</subject><subject>Ischemic heart disease</subject><subject>Male</subject><subject>Meta-analysis</subject><subject>Odds Ratio</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Systematic reviews and meta-analyses</subject><subject>Uric acid</subject><subject>Uric Acid - blood</subject><subject>Womens health</subject><issn>1549-1676</issn><issn>1549-1277</issn><issn>1549-1676</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>DOA</sourceid><recordid>eNptUsFu1DAQjRCIlsIfILCExKlZZmLHjjkgoQraSpV6oHfLazutV0kc7KTSSnw83t0ALerJI_u955k3ryjeIqyQCvy0CXMcdLcae2dXABWA4M-KY6yZLJEL_vxBfVS8SmmTQRIkvCyOsBYNrTgcF79-uDj3ZI7eEG28JXqwxIQYBh235M7pOBHrk9PJET8QecrqJhcZ6YaJmHyd9hSs61NoWKYOUwxd-kzGGNLozOTvHUnTbLd7XO8mXerc9zb59Lp40eouuTfLeVLcfP92c3ZRXl2fX559vSpNLWEq0aCoqKWGogPDkDPLhcUWLdg1moZyxiRnFBGAtrW0dr1zo0XBK8YdPSneH2THLiS1-JYUVk0DAoCJjLg8IGzQGzVG3-fpVdBe7S9CvFXZCG86p6qK1baxjaxaxmrJpV4j04gNUo1G26z1ZfltXufVmOxT1N0j0ccvg79Tt-FeIXDJ-a6Zj4tADD9nlybV-2Rc1-nBhTkpLqRgvOIZ-OE_4NOzsQPK5IWk6Nq_rSCoXZL-sNQuSWpJUqa9ezjGP9ISHfobfdLFGg</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Wheeler, Jeremy G</creator><creator>Juzwishin, Kelsey D M</creator><creator>Eiriksdottir, Gudny</creator><creator>Gudnason, Vilmundur</creator><creator>Danesh, John</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><scope>CZK</scope></search><sort><creationdate>20050301</creationdate><title>Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis</title><author>Wheeler, Jeremy G ; Juzwishin, Kelsey D M ; Eiriksdottir, Gudny ; Gudnason, Vilmundur ; Danesh, John</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-1c1723d3c31e0c4164d67d1f1d0db1c83644964311003f59ddb2007f176246e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - blood</topic><topic>Blood pressure</topic><topic>Cardiology/Cardiac Surgery</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Medicine</topic><topic>Case-Control Studies</topic><topic>Confidence intervals</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - physiopathology</topic><topic>Epidemiology</topic><topic>Epidemiology/Public Health</topic><topic>Female</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Iceland - epidemiology</topic><topic>Incidence</topic><topic>Ischemic heart disease</topic><topic>Male</topic><topic>Meta-analysis</topic><topic>Odds Ratio</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Systematic reviews and meta-analyses</topic><topic>Uric acid</topic><topic>Uric Acid - blood</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wheeler, Jeremy G</creatorcontrib><creatorcontrib>Juzwishin, Kelsey D M</creatorcontrib><creatorcontrib>Eiriksdottir, Gudny</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Danesh, John</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><collection>PLoS Medicine</collection><jtitle>PLoS medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wheeler, Jeremy G</au><au>Juzwishin, Kelsey D M</au><au>Eiriksdottir, Gudny</au><au>Gudnason, Vilmundur</au><au>Danesh, John</au><au>Keech, Anthony</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis</atitle><jtitle>PLoS medicine</jtitle><addtitle>PLoS Med</addtitle><date>2005-03-01</date><risdate>2005</risdate><volume>2</volume><issue>3</issue><spage>e76</spage><epage>e76</epage><pages>e76-e76</pages><issn>1549-1676</issn><issn>1549-1277</issn><eissn>1549-1676</eissn><abstract>It has been suggested throughout the past fifty years that serum uric acid concentrations can help predict the future risk of coronary heart disease (CHD), but the epidemiological evidence is uncertain.
We report a "nested" case-control comparison within a prospective study in Reykjavik, Iceland, using baseline values of serum uric acid in 2,456 incident CHD cases and in 3,962 age- and sex-matched controls, plus paired serum uric acid measurements taken at baseline and, on average, 12 y later in 379 participants. In addition, we conducted a meta-analysis of 15 other prospective studies in eight countries conducted in essentially general populations. Compared with individuals in the bottom third of baseline measurements of serum uric acid in the Reykjavik study, those in the top third had an age- and sex-adjusted odds ratio for CHD of 1.39 (95% confidence interval [CI], 1.23-1.58) which fell to 1.12 (CI, 0.97-1.30) after adjustment for smoking and other established risk factors. Overall, in a combined analysis of 9,458 cases and 155,084 controls in all 16 relevant prospective studies, the odds ratio was 1.13 (CI, 1.07-1.20), but it was only 1.02 (CI, 0.91-1.14) in the eight studies with more complete adjustment for possible confounders.
Measurement of serum uric acid levels is unlikely to enhance usefully the prediction of CHD, and this factor is unlikely to be a major determinant of the disease in general populations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>15783260</pmid><doi>10.1371/journal.pmed.0020076</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Biomarkers - blood Blood pressure Cardiology/Cardiac Surgery Cardiovascular disease Cardiovascular Medicine Case-Control Studies Confidence intervals Coronary Artery Disease - epidemiology Coronary Artery Disease - physiopathology Epidemiology Epidemiology/Public Health Female Heart attacks Humans Iceland - epidemiology Incidence Ischemic heart disease Male Meta-analysis Odds Ratio Predictive Value of Tests Prospective Studies Risk Factors Sex Factors Systematic reviews and meta-analyses Uric acid Uric Acid - blood Womens health |
| title | Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysis |
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