Prions: Some Physiological and Pathophysiological Aspects
The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic di...
Gespeichert in:
1. Verfasser: | |
---|---|
Format: | Buch |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | |
container_start_page | |
container_title | |
container_volume | |
creator | Ivo Nikolaev Sirakov |
description | The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE. |
doi_str_mv | 10.5772/intechopen.74080 |
format | Book |
fullrecord | <record><control><sourceid>perlego_oapen</sourceid><recordid>TN_cdi_perlego_books_2025888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2025888</sourcerecordid><originalsourceid>FETCH-LOGICAL-f4152-f1d15d2f1934e276f6044eff9682631204290c9c7b85132fdb06b68809b779e53</originalsourceid><addsrcrecordid>eNotz01LAzEQxvGAKEq7d0G_wtbJJJOZOUrxpVDQQz0vm91Eq2VTGr8_FtbTc_jBA39jbi2siBkf9tNvGr7KMU0r9iBwYRplsSwqBFbo2jS1fgMAqldBvDFX76d9merSXOb-UFPzvwvz8fy0W7-227eXzfpx22ZvCdtsR0sjZqvOJ-SQA3ifctYgGJxF8Kgw6MBRyDrMY4QQgwhoZNZEbmHu599jOh3SZ-liKT-1Q0ASkTPfzVz6c0M3ln72EJTI_QEXxzx9</addsrcrecordid><sourcetype>Publisher</sourcetype><iscdi>true</iscdi><recordtype>book</recordtype></control><display><type>book</type><title>Prions: Some Physiological and Pathophysiological Aspects</title><source>InTech Open Access Books</source><creator>Ivo Nikolaev Sirakov</creator><contributor>Nikolaev Sirakov, Ivo</contributor><creatorcontrib>Ivo Nikolaev Sirakov ; Nikolaev Sirakov, Ivo</creatorcontrib><description>The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.</description><identifier>ISBN: 9781789850185</identifier><identifier>ISBN: 1789850185</identifier><identifier>ISBN: 1789850177</identifier><identifier>ISBN: 9781789850178</identifier><identifier>ISBN: 1838817689</identifier><identifier>ISBN: 9781838817688</identifier><identifier>DOI: 10.5772/intechopen.74080</identifier><language>eng</language><publisher>IntechOpen</publisher><subject>Clinical and internal medicine ; Diseases and disorders ; Infectious & contagious diseases ; Infectious and contagious diseases ; MEDICAL ; Medicine and Nursing ; thema EDItEUR</subject><creationdate>2019</creationdate><tpages>82</tpages><format>82</format><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>307,781,785,787,27930</link.rule.ids></links><search><contributor>Nikolaev Sirakov, Ivo</contributor><creatorcontrib>Ivo Nikolaev Sirakov</creatorcontrib><title>Prions: Some Physiological and Pathophysiological Aspects</title><description>The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.</description><subject>Clinical and internal medicine</subject><subject>Diseases and disorders</subject><subject>Infectious & contagious diseases</subject><subject>Infectious and contagious diseases</subject><subject>MEDICAL</subject><subject>Medicine and Nursing</subject><subject>thema EDItEUR</subject><isbn>9781789850185</isbn><isbn>1789850185</isbn><isbn>1789850177</isbn><isbn>9781789850178</isbn><isbn>1838817689</isbn><isbn>9781838817688</isbn><fulltext>true</fulltext><rsrctype>book</rsrctype><creationdate>2019</creationdate><recordtype>book</recordtype><sourceid>V1H</sourceid><recordid>eNotz01LAzEQxvGAKEq7d0G_wtbJJJOZOUrxpVDQQz0vm91Eq2VTGr8_FtbTc_jBA39jbi2siBkf9tNvGr7KMU0r9iBwYRplsSwqBFbo2jS1fgMAqldBvDFX76d9merSXOb-UFPzvwvz8fy0W7-227eXzfpx22ZvCdtsR0sjZqvOJ-SQA3ifctYgGJxF8Kgw6MBRyDrMY4QQgwhoZNZEbmHu599jOh3SZ-liKT-1Q0ASkTPfzVz6c0M3ln72EJTI_QEXxzx9</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Ivo Nikolaev Sirakov</creator><general>IntechOpen</general><scope>V1H</scope><scope>YSPEL</scope></search><sort><creationdate>2019</creationdate><title>Prions</title><author>Ivo Nikolaev Sirakov</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f4152-f1d15d2f1934e276f6044eff9682631204290c9c7b85132fdb06b68809b779e53</frbrgroupid><rsrctype>books</rsrctype><prefilter>books</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Clinical and internal medicine</topic><topic>Diseases and disorders</topic><topic>Infectious & contagious diseases</topic><topic>Infectious and contagious diseases</topic><topic>MEDICAL</topic><topic>Medicine and Nursing</topic><topic>thema EDItEUR</topic><toplevel>online_resources</toplevel><creatorcontrib>Ivo Nikolaev Sirakov</creatorcontrib><collection>DOAB: Directory of Open Access Books</collection><collection>Perlego</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ivo Nikolaev Sirakov</au><au>Nikolaev Sirakov, Ivo</au><format>book</format><genre>book</genre><ristype>BOOK</ristype><btitle>Prions: Some Physiological and Pathophysiological Aspects</btitle><date>2019</date><risdate>2019</risdate><isbn>9781789850185</isbn><isbn>1789850185</isbn><isbn>1789850177</isbn><isbn>9781789850178</isbn><isbn>1838817689</isbn><isbn>9781838817688</isbn><abstract>The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.</abstract><pub>IntechOpen</pub><doi>10.5772/intechopen.74080</doi><tpages>82</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISBN: 9781789850185 |
ispartof | |
issn | |
language | eng |
recordid | cdi_perlego_books_2025888 |
source | InTech Open Access Books |
subjects | Clinical and internal medicine Diseases and disorders Infectious & contagious diseases Infectious and contagious diseases MEDICAL Medicine and Nursing thema EDItEUR |
title | Prions: Some Physiological and Pathophysiological Aspects |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T11%3A35%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-perlego_oapen&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.btitle=Prions:%20Some%20Physiological%20and%20Pathophysiological%20Aspects&rft.au=Ivo%20Nikolaev%20Sirakov&rft.date=2019&rft.isbn=9781789850185&rft.isbn_list=1789850185&rft.isbn_list=1789850177&rft.isbn_list=9781789850178&rft.isbn_list=1838817689&rft.isbn_list=9781838817688&rft_id=info:doi/10.5772/intechopen.74080&rft_dat=%3Cperlego_oapen%3E2025888%3C/perlego_oapen%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |