The Relationship between Revascularisation and Osteogenesis in Fresh or Demineralised Bone Grafts
Bone formation generally depends on adequate blood flow. Failure of bone grafts has been attributed to delayed revascularisation of the graft. We compared the relationship between revascularisation and osteogenesis, evaluated as entrapment of 141 Ce-labelled microspheres and uptake of 85 Sr, respect...
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| Veröffentlicht in: | European surgical research 2001-01, Vol.33 (1), p.42-46 |
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| creator | Solheim, E. Pinholt, Else M. Talsnes, O. Larsen, Trine Berg Kirkeby, O.J. |
| description | Bone formation generally depends on adequate blood flow. Failure of bone grafts has been attributed to delayed revascularisation of the graft. We compared the relationship between revascularisation and osteogenesis, evaluated as entrapment of 141 Ce-labelled microspheres and uptake of 85 Sr, respectively, in fresh or demineralised syngeneic bone grafts 3 weeks after heterotopic implantation in rats. Whereas a moderately high linear correlation between 85 Sr and 141 Ce radioactivity was found both in the (intact) host iliac bone (r = 0.75, p = 0.0001) and implanted fresh syngeneic grafts (r = 0.50, p = 0.001), no correlation could be demonstrated in demineralised grafts (r = 0.09, p = 0.6). The results may indicate differences in the mechanisms of vascularisation and osteogenesis in the grafts used fresh or after demineralization but are, at present, difficult to fully explain. |
| doi_str_mv | 10.1159/000049692 |
| format | Article |
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Failure of bone grafts has been attributed to delayed revascularisation of the graft. We compared the relationship between revascularisation and osteogenesis, evaluated as entrapment of 141 Ce-labelled microspheres and uptake of 85 Sr, respectively, in fresh or demineralised syngeneic bone grafts 3 weeks after heterotopic implantation in rats. Whereas a moderately high linear correlation between 85 Sr and 141 Ce radioactivity was found both in the (intact) host iliac bone (r = 0.75, p = 0.0001) and implanted fresh syngeneic grafts (r = 0.50, p = 0.001), no correlation could be demonstrated in demineralised grafts (r = 0.09, p = 0.6). The results may indicate differences in the mechanisms of vascularisation and osteogenesis in the grafts used fresh or after demineralization but are, at present, difficult to fully explain.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - blood supply</subject><subject>Bone and Bones - physiopathology</subject><subject>Bone Demineralization Technique</subject><subject>Bone Density</subject><subject>Bone Transplantation</subject><subject>Diseases of the osteoarticular system</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Neovascularization, Physiologic</subject><subject>Original Paper</subject><subject>Osteogenesis</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Transplantation, Isogeneic</subject><issn>0014-312X</issn><issn>1421-9921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0E1r3DAQBmARGpJtkkPOhSJaKPTgVJJlWzq2ab4gEEj3kJsZy-OsUq-80dgt_fdVssumlOggIelhZngZO5biRMrCfhFpaVtatcNmUiuZWavkGzYTQuosl-pun70lekjXwlZ2j-1LmWuhKjVjMF8gv8UeRj8EWvgVb3D8jRjS4y8gN_UQPT3_cggtv6ERh3sMSJ64D_w8Ii34EPl3XPqAEXpP2PJvQ0B-EaEb6ZDtdtATHm3OAzY_P5ufXmbXNxdXp1-vM5cbPWa2LYzRpSl0C01Ztq0xTYmu6jrdOK1tXlTWOGygVAhVozrQpTYNgCgK5Vx-wD6ty67i8DghjfXSk8O-h4DDRHUljDSVLRP8-B98GKYY0mi1FCnDPO0iqc9r5eJAFLGrV9EvIf5JqH4Kvd6Gnuz7TcWpWWL7Ijcp_9MyJQp9FyE4T1tnq1zIJ_VhrX5CvMe4_T77cfvcp161XULvXkXrSf4CzT6dlg</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Solheim, E.</creator><creator>Pinholt, Else M.</creator><creator>Talsnes, O.</creator><creator>Larsen, Trine Berg</creator><creator>Kirkeby, O.J.</creator><general>Karger</general><general>S. 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Failure of bone grafts has been attributed to delayed revascularisation of the graft. We compared the relationship between revascularisation and osteogenesis, evaluated as entrapment of 141 Ce-labelled microspheres and uptake of 85 Sr, respectively, in fresh or demineralised syngeneic bone grafts 3 weeks after heterotopic implantation in rats. Whereas a moderately high linear correlation between 85 Sr and 141 Ce radioactivity was found both in the (intact) host iliac bone (r = 0.75, p = 0.0001) and implanted fresh syngeneic grafts (r = 0.50, p = 0.001), no correlation could be demonstrated in demineralised grafts (r = 0.09, p = 0.6). The results may indicate differences in the mechanisms of vascularisation and osteogenesis in the grafts used fresh or after demineralization but are, at present, difficult to fully explain.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11340272</pmid><doi>10.1159/000049692</doi><tpages>5</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Bone and Bones - blood supply Bone and Bones - physiopathology Bone Demineralization Technique Bone Density Bone Transplantation Diseases of the osteoarticular system Male Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Neovascularization, Physiologic Original Paper Osteogenesis Rats Rats, Inbred Lew Transplantation, Isogeneic |
| title | The Relationship between Revascularisation and Osteogenesis in Fresh or Demineralised Bone Grafts |
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