Natural Course of the Functional and Morphological Changes in Canine Autogenous Arterial Graft
Background: We examined the time course of endothelium-dependent and -independent responses in reversed autogenous arterial grafts during regeneration and tissue repair processes after arterial grafting in dogs. Materials and Methods: Autogenous arterial grafts implanted in the canine femoral artery...
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| Veröffentlicht in: | European surgical research 2001-01, Vol.33 (1), p.21-27 |
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| creator | Wei, C.-G. Komori, K. Mori, E. Kume, M. Yamaoka, T. Matsumoto, T. Sugimachi, K. |
| description | Background: We examined the time course of endothelium-dependent and -independent responses in reversed autogenous arterial grafts during regeneration and tissue repair processes after arterial grafting in dogs. Materials and Methods: Autogenous arterial grafts implanted in the canine femoral artery were removed, cut into rings and suspended in organ chambers for isometric tension recording on the 1st, 3rd, 7th, 14th and 28th days after implantation. Electron-microscopic examination on the 1st, 3rd ,7th, 14th and 28th days after transplantation was also performed. Control arteries were taken from nonsurgically treated femoral arteries. Results: Acetylcholine (ACh) and A23187 caused endothelium-dependent relaxations in arterial grafts throughout the study. Although endothelium-dependent relaxations to ACh and A23187 on the 3rd day after transplantation were only significantly impaired compared to those of control, they were similar to the control within 1 week after grafting. Smooth muscle relaxations in response to sodium nitroprusside in arterial grafts throughout the study were comparable with those of control arteries. No apparent intimal thickening of the arterial grafts was observed. Electron microscopy scanning revealed mild endothelial cell damage in implanted autogenous arterial grafts on the 1st or 3rd day after grafting. Seven to 14 days after grafting, the endothelial cell layer appeared to be normal. Conclusions: It was observed that the endothelial function remained intact and there was an absence of intimal thickening in the arterial grafts. These observations may explain the improved patency of autogenous arterial grafts compared to the vein grafts in aortocoronary revascularization. |
| doi_str_mv | 10.1159/000049688 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_972264</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70823038</sourcerecordid><originalsourceid>FETCH-LOGICAL-c450t-d6500c186efc3fc9cecfa1e6a9ca1a15705b4513fa3d8ed550be31f7b815c08a3</originalsourceid><addsrcrecordid>eNpt0E2LFDEQBuAgijuuHjwL0igseGhNJZ3u5DgM-wWrgh_gyaYmXZnptSeZTboP--_NOrOzIuYSQj1UpV7GXgJ_D6DMB55PZWqtH7EZVAJKYwQ8ZjPOoSoliB9H7FlK1_mpTGOesiMAWXFR6xn7-QnHKeJQLMIUExXBFeOairPJ27EPPhfQd8XHELfrMIRVb-_oGv2KUtH7YoG-91TMpzGsyIcpFfM4UuyzOo_oxufsicMh0Yv9fcy-n51-W1yUV5_PLxfzq9JWio9lVyvOLeianJXOGkvWIVCNxiIgqIarZaVAOpSdpk4pviQJrllqUJZrlMfsZNd3G8PNRGlsN32yNAzoKf-qbbgWkkud4dt_4HVePO-ZWuC1ETJHI7J6t1M2hpQiuXYb-w3G24zau8jbQ-TZvt53nJYb6h7kPuO_RmLK8bmI3vbp4EwjRF1l9WqnfmFcUTyU74e8-W_19OuXP6Dddk7-BkUVnEU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1069231132</pqid></control><display><type>article</type><title>Natural Course of the Functional and Morphological Changes in Canine Autogenous Arterial Graft</title><source>MEDLINE</source><source>Karger Journals</source><creator>Wei, C.-G. ; Komori, K. ; Mori, E. ; Kume, M. ; Yamaoka, T. ; Matsumoto, T. ; Sugimachi, K.</creator><creatorcontrib>Wei, C.-G. ; Komori, K. ; Mori, E. ; Kume, M. ; Yamaoka, T. ; Matsumoto, T. ; Sugimachi, K.</creatorcontrib><description>Background: We examined the time course of endothelium-dependent and -independent responses in reversed autogenous arterial grafts during regeneration and tissue repair processes after arterial grafting in dogs. Materials and Methods: Autogenous arterial grafts implanted in the canine femoral artery were removed, cut into rings and suspended in organ chambers for isometric tension recording on the 1st, 3rd, 7th, 14th and 28th days after implantation. Electron-microscopic examination on the 1st, 3rd ,7th, 14th and 28th days after transplantation was also performed. Control arteries were taken from nonsurgically treated femoral arteries. Results: Acetylcholine (ACh) and A23187 caused endothelium-dependent relaxations in arterial grafts throughout the study. Although endothelium-dependent relaxations to ACh and A23187 on the 3rd day after transplantation were only significantly impaired compared to those of control, they were similar to the control within 1 week after grafting. Smooth muscle relaxations in response to sodium nitroprusside in arterial grafts throughout the study were comparable with those of control arteries. No apparent intimal thickening of the arterial grafts was observed. Electron microscopy scanning revealed mild endothelial cell damage in implanted autogenous arterial grafts on the 1st or 3rd day after grafting. Seven to 14 days after grafting, the endothelial cell layer appeared to be normal. Conclusions: It was observed that the endothelial function remained intact and there was an absence of intimal thickening in the arterial grafts. These observations may explain the improved patency of autogenous arterial grafts compared to the vein grafts in aortocoronary revascularization.</description><identifier>ISSN: 0014-312X</identifier><identifier>EISSN: 1421-9921</identifier><identifier>DOI: 10.1159/000049688</identifier><identifier>PMID: 11340268</identifier><identifier>CODEN: EUSRBM</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Animals ; Arteries - pathology ; Arteries - transplantation ; Biological and medical sciences ; Dogs ; Female ; Femoral Artery - surgery ; Male ; Medical sciences ; Microscopy, Electron ; Miscellaneous ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - physiopathology ; Nitroprusside - pharmacology ; Norepinephrine - pharmacology ; Original Paper ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Transplantation, Autologous ; Vasoconstriction ; Vasoconstrictor Agents - pharmacology ; Vasodilation</subject><ispartof>European surgical research, 2001-01, Vol.33 (1), p.21-27</ispartof><rights>2001 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright (c) 2001 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-d6500c186efc3fc9cecfa1e6a9ca1a15705b4513fa3d8ed550be31f7b815c08a3</citedby><cites>FETCH-LOGICAL-c450t-d6500c186efc3fc9cecfa1e6a9ca1a15705b4513fa3d8ed550be31f7b815c08a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,2427,4022,4048,4049,23929,23930,25139,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=972264$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11340268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, C.-G.</creatorcontrib><creatorcontrib>Komori, K.</creatorcontrib><creatorcontrib>Mori, E.</creatorcontrib><creatorcontrib>Kume, M.</creatorcontrib><creatorcontrib>Yamaoka, T.</creatorcontrib><creatorcontrib>Matsumoto, T.</creatorcontrib><creatorcontrib>Sugimachi, K.</creatorcontrib><title>Natural Course of the Functional and Morphological Changes in Canine Autogenous Arterial Graft</title><title>European surgical research</title><addtitle>Eur Surg Res</addtitle><description>Background: We examined the time course of endothelium-dependent and -independent responses in reversed autogenous arterial grafts during regeneration and tissue repair processes after arterial grafting in dogs. Materials and Methods: Autogenous arterial grafts implanted in the canine femoral artery were removed, cut into rings and suspended in organ chambers for isometric tension recording on the 1st, 3rd, 7th, 14th and 28th days after implantation. Electron-microscopic examination on the 1st, 3rd ,7th, 14th and 28th days after transplantation was also performed. Control arteries were taken from nonsurgically treated femoral arteries. Results: Acetylcholine (ACh) and A23187 caused endothelium-dependent relaxations in arterial grafts throughout the study. Although endothelium-dependent relaxations to ACh and A23187 on the 3rd day after transplantation were only significantly impaired compared to those of control, they were similar to the control within 1 week after grafting. Smooth muscle relaxations in response to sodium nitroprusside in arterial grafts throughout the study were comparable with those of control arteries. No apparent intimal thickening of the arterial grafts was observed. Electron microscopy scanning revealed mild endothelial cell damage in implanted autogenous arterial grafts on the 1st or 3rd day after grafting. Seven to 14 days after grafting, the endothelial cell layer appeared to be normal. Conclusions: It was observed that the endothelial function remained intact and there was an absence of intimal thickening in the arterial grafts. These observations may explain the improved patency of autogenous arterial grafts compared to the vein grafts in aortocoronary revascularization.</description><subject>Animals</subject><subject>Arteries - pathology</subject><subject>Arteries - transplantation</subject><subject>Biological and medical sciences</subject><subject>Dogs</subject><subject>Female</subject><subject>Femoral Artery - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Miscellaneous</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiopathology</subject><subject>Nitroprusside - pharmacology</subject><subject>Norepinephrine - pharmacology</subject><subject>Original Paper</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Transplantation, Autologous</subject><subject>Vasoconstriction</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>Vasodilation</subject><issn>0014-312X</issn><issn>1421-9921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpt0E2LFDEQBuAgijuuHjwL0igseGhNJZ3u5DgM-wWrgh_gyaYmXZnptSeZTboP--_NOrOzIuYSQj1UpV7GXgJ_D6DMB55PZWqtH7EZVAJKYwQ8ZjPOoSoliB9H7FlK1_mpTGOesiMAWXFR6xn7-QnHKeJQLMIUExXBFeOairPJ27EPPhfQd8XHELfrMIRVb-_oGv2KUtH7YoG-91TMpzGsyIcpFfM4UuyzOo_oxufsicMh0Yv9fcy-n51-W1yUV5_PLxfzq9JWio9lVyvOLeianJXOGkvWIVCNxiIgqIarZaVAOpSdpk4pviQJrllqUJZrlMfsZNd3G8PNRGlsN32yNAzoKf-qbbgWkkud4dt_4HVePO-ZWuC1ETJHI7J6t1M2hpQiuXYb-w3G24zau8jbQ-TZvt53nJYb6h7kPuO_RmLK8bmI3vbp4EwjRF1l9WqnfmFcUTyU74e8-W_19OuXP6Dddk7-BkUVnEU</recordid><startdate>200101</startdate><enddate>200101</enddate><creator>Wei, C.-G.</creator><creator>Komori, K.</creator><creator>Mori, E.</creator><creator>Kume, M.</creator><creator>Yamaoka, T.</creator><creator>Matsumoto, T.</creator><creator>Sugimachi, K.</creator><general>Karger</general><general>S. Karger AG</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>200101</creationdate><title>Natural Course of the Functional and Morphological Changes in Canine Autogenous Arterial Graft</title><author>Wei, C.-G. ; Komori, K. ; Mori, E. ; Kume, M. ; Yamaoka, T. ; Matsumoto, T. ; Sugimachi, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-d6500c186efc3fc9cecfa1e6a9ca1a15705b4513fa3d8ed550be31f7b815c08a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Arteries - pathology</topic><topic>Arteries - transplantation</topic><topic>Biological and medical sciences</topic><topic>Dogs</topic><topic>Female</topic><topic>Femoral Artery - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Miscellaneous</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiopathology</topic><topic>Nitroprusside - pharmacology</topic><topic>Norepinephrine - pharmacology</topic><topic>Original Paper</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Transplantation, Autologous</topic><topic>Vasoconstriction</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, C.-G.</creatorcontrib><creatorcontrib>Komori, K.</creatorcontrib><creatorcontrib>Mori, E.</creatorcontrib><creatorcontrib>Kume, M.</creatorcontrib><creatorcontrib>Yamaoka, T.</creatorcontrib><creatorcontrib>Matsumoto, T.</creatorcontrib><creatorcontrib>Sugimachi, K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, C.-G.</au><au>Komori, K.</au><au>Mori, E.</au><au>Kume, M.</au><au>Yamaoka, T.</au><au>Matsumoto, T.</au><au>Sugimachi, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural Course of the Functional and Morphological Changes in Canine Autogenous Arterial Graft</atitle><jtitle>European surgical research</jtitle><addtitle>Eur Surg Res</addtitle><date>2001-01</date><risdate>2001</risdate><volume>33</volume><issue>1</issue><spage>21</spage><epage>27</epage><pages>21-27</pages><issn>0014-312X</issn><eissn>1421-9921</eissn><coden>EUSRBM</coden><abstract>Background: We examined the time course of endothelium-dependent and -independent responses in reversed autogenous arterial grafts during regeneration and tissue repair processes after arterial grafting in dogs. Materials and Methods: Autogenous arterial grafts implanted in the canine femoral artery were removed, cut into rings and suspended in organ chambers for isometric tension recording on the 1st, 3rd, 7th, 14th and 28th days after implantation. Electron-microscopic examination on the 1st, 3rd ,7th, 14th and 28th days after transplantation was also performed. Control arteries were taken from nonsurgically treated femoral arteries. Results: Acetylcholine (ACh) and A23187 caused endothelium-dependent relaxations in arterial grafts throughout the study. Although endothelium-dependent relaxations to ACh and A23187 on the 3rd day after transplantation were only significantly impaired compared to those of control, they were similar to the control within 1 week after grafting. Smooth muscle relaxations in response to sodium nitroprusside in arterial grafts throughout the study were comparable with those of control arteries. No apparent intimal thickening of the arterial grafts was observed. Electron microscopy scanning revealed mild endothelial cell damage in implanted autogenous arterial grafts on the 1st or 3rd day after grafting. Seven to 14 days after grafting, the endothelial cell layer appeared to be normal. Conclusions: It was observed that the endothelial function remained intact and there was an absence of intimal thickening in the arterial grafts. These observations may explain the improved patency of autogenous arterial grafts compared to the vein grafts in aortocoronary revascularization.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11340268</pmid><doi>10.1159/000049688</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Arteries - pathology Arteries - transplantation Biological and medical sciences Dogs Female Femoral Artery - surgery Male Medical sciences Microscopy, Electron Miscellaneous Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiopathology Nitroprusside - pharmacology Norepinephrine - pharmacology Original Paper Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation, Autologous Vasoconstriction Vasoconstrictor Agents - pharmacology Vasodilation |
| title | Natural Course of the Functional and Morphological Changes in Canine Autogenous Arterial Graft |
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