Conventional malabsorption tests: Do they detect the adult patient with villous atrophy?
Gillberg, R., Dotevall, G., Kastrup, W., Lindstedt, G., Mobacken, H. & Swolin, B. Conventional malabsorption tests: do they detect the adult patient with villous atrophy? A total number of 134 patients with subtotal or partial villous atrophy, of whom 49 had dermatitis herpetiformis, were invest...
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| Veröffentlicht in: | Scandinavian journal of clinical and laboratory investigation 1984-01, Vol.44 (1), p.91-98 |
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| container_title | Scandinavian journal of clinical and laboratory investigation |
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| creator | Gillberg, R. Dotevall, G. Kastrup, W. Lindstedt, G. Mobacken, H. Swolin, B. |
| description | Gillberg, R., Dotevall, G., Kastrup, W., Lindstedt, G., Mobacken, H. & Swolin, B. Conventional malabsorption tests: do they detect the adult patient with villous atrophy?
A total number of 134 patients with subtotal or partial villous atrophy, of whom 49 had dermatitis herpetiformis, were investigated with blood folate assay and xylose and lactose absorption tests. Faecal fat excretion was determined in 71 patients without dermatitis herpetiformis (coeliac group). A comparison was made between three patient groups, the patients with dermatitis herpetiformis and the coeliac patients studied in 1970-74 and 1975-79, respectively. From clinical and biochemical analyses of these patients we conclude that although a combination of the four malabsorption tests used here still detect a majority of coeliac patients, small intestinal biopsy may reveal villous atrophy also in patients without any laboratory evidence for malabsorption by these commonly used tests. In dermatitis herpetiformis, however, the sensitivity of the tests used was low; these malabsorption tests therefore have little diagnostic value in this category of patients. |
| doi_str_mv | 10.3109/00365518409083792 |
| format | Article |
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A total number of 134 patients with subtotal or partial villous atrophy, of whom 49 had dermatitis herpetiformis, were investigated with blood folate assay and xylose and lactose absorption tests. Faecal fat excretion was determined in 71 patients without dermatitis herpetiformis (coeliac group). A comparison was made between three patient groups, the patients with dermatitis herpetiformis and the coeliac patients studied in 1970-74 and 1975-79, respectively. From clinical and biochemical analyses of these patients we conclude that although a combination of the four malabsorption tests used here still detect a majority of coeliac patients, small intestinal biopsy may reveal villous atrophy also in patients without any laboratory evidence for malabsorption by these commonly used tests. In dermatitis herpetiformis, however, the sensitivity of the tests used was low; these malabsorption tests therefore have little diagnostic value in this category of patients.</description><identifier>ISSN: 0036-5513</identifier><identifier>EISSN: 1502-7686</identifier><identifier>DOI: 10.3109/00365518409083792</identifier><identifier>PMID: 6701455</identifier><identifier>CODEN: SJCLAY</identifier><language>eng</language><publisher>Oslo: Informa UK Ltd</publisher><subject>Adult ; Aged ; Atrophy ; Biological and medical sciences ; Celiac Disease - pathology ; coeliac disease ; dermatitis herpetiformis ; Dermatitis Herpetiformis - pathology ; faecal fat determination ; Female ; folate assay ; Folic Acid - blood ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Intestines - pathology ; Lactose ; lactose absorption test ; malabsorption ; Malabsorption Syndromes - diagnosis ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; test sensitivity ; villous atrophy ; Xylose ; xylose test</subject><ispartof>Scandinavian journal of clinical and laboratory investigation, 1984-01, Vol.44 (1), p.91-98</ispartof><rights>1984 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-88367a0280eeecaa4eeef864117e5772555637fdaf9def858441ff31b6db11f43</citedby><cites>FETCH-LOGICAL-c430t-88367a0280eeecaa4eeef864117e5772555637fdaf9def858441ff31b6db11f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365518409083792$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365518409083792$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9679220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6701455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gillberg, R.</creatorcontrib><creatorcontrib>Dotevall, G.</creatorcontrib><creatorcontrib>Kastrup, W.</creatorcontrib><creatorcontrib>Lindstedt, G.</creatorcontrib><creatorcontrib>Mobacken, H.</creatorcontrib><creatorcontrib>Swolin, B.</creatorcontrib><title>Conventional malabsorption tests: Do they detect the adult patient with villous atrophy?</title><title>Scandinavian journal of clinical and laboratory investigation</title><addtitle>Scand J Clin Lab Invest</addtitle><description>Gillberg, R., Dotevall, G., Kastrup, W., Lindstedt, G., Mobacken, H. & Swolin, B. Conventional malabsorption tests: do they detect the adult patient with villous atrophy?
A total number of 134 patients with subtotal or partial villous atrophy, of whom 49 had dermatitis herpetiformis, were investigated with blood folate assay and xylose and lactose absorption tests. Faecal fat excretion was determined in 71 patients without dermatitis herpetiformis (coeliac group). A comparison was made between three patient groups, the patients with dermatitis herpetiformis and the coeliac patients studied in 1970-74 and 1975-79, respectively. From clinical and biochemical analyses of these patients we conclude that although a combination of the four malabsorption tests used here still detect a majority of coeliac patients, small intestinal biopsy may reveal villous atrophy also in patients without any laboratory evidence for malabsorption by these commonly used tests. In dermatitis herpetiformis, however, the sensitivity of the tests used was low; these malabsorption tests therefore have little diagnostic value in this category of patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Celiac Disease - pathology</subject><subject>coeliac disease</subject><subject>dermatitis herpetiformis</subject><subject>Dermatitis Herpetiformis - pathology</subject><subject>faecal fat determination</subject><subject>Female</subject><subject>folate assay</subject><subject>Folic Acid - blood</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Intestines - pathology</subject><subject>Lactose</subject><subject>lactose absorption test</subject><subject>malabsorption</subject><subject>Malabsorption Syndromes - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>test sensitivity</subject><subject>villous atrophy</subject><subject>Xylose</subject><subject>xylose test</subject><issn>0036-5513</issn><issn>1502-7686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uctq3DAUFaUhnaT9gCwKWpTsnEjWw3IbCGHyhEA2LXRn7tgS9iBbriQn-O-jYSaBEpjV1eU8OPcIoRNKzhgl5TkhTApBFSclUawo809oQQXJs0Iq-RktNniWCOwLOgphTdLOFD9Eh7IglAuxQH-XbnjWQ-zcABb3YGEVnB83O446xPATXzscWz3jRkddx80bQzPZiEeIXZLily62-Lmz1k0BQ_RubOfLr-jAgA36224eoz-3N7-X99nj093D8uoxqzkjMVOKyQJIrojWugbgaRglOaWFFkWRCyEkK0wDpmwSIBTn1BhGV7JZUWo4O0anW9_Ru39TSlz1Xai1tTDolKdSpFRlEiUi3RJr70Lw2lSj73rwc0VJtWmz-tBm0nzfmU-rXjfvil19Cf-xwyHUYI2Hoe7CO62UySQniXaxpXWDcb6HF-dtU0WYrfNvGrYvxa__5K0GG9savK7WbvLp48KeG14B6dCifA</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Gillberg, R.</creator><creator>Dotevall, G.</creator><creator>Kastrup, W.</creator><creator>Lindstedt, G.</creator><creator>Mobacken, H.</creator><creator>Swolin, B.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Conventional malabsorption tests: Do they detect the adult patient with villous atrophy?</title><author>Gillberg, R. ; Dotevall, G. ; Kastrup, W. ; Lindstedt, G. ; Mobacken, H. ; Swolin, B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-88367a0280eeecaa4eeef864117e5772555637fdaf9def858441ff31b6db11f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Celiac Disease - pathology</topic><topic>coeliac disease</topic><topic>dermatitis herpetiformis</topic><topic>Dermatitis Herpetiformis - pathology</topic><topic>faecal fat determination</topic><topic>Female</topic><topic>folate assay</topic><topic>Folic Acid - blood</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Intestines - pathology</topic><topic>Lactose</topic><topic>lactose absorption test</topic><topic>malabsorption</topic><topic>Malabsorption Syndromes - diagnosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>test sensitivity</topic><topic>villous atrophy</topic><topic>Xylose</topic><topic>xylose test</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gillberg, R.</creatorcontrib><creatorcontrib>Dotevall, G.</creatorcontrib><creatorcontrib>Kastrup, W.</creatorcontrib><creatorcontrib>Lindstedt, G.</creatorcontrib><creatorcontrib>Mobacken, H.</creatorcontrib><creatorcontrib>Swolin, B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gillberg, R.</au><au>Dotevall, G.</au><au>Kastrup, W.</au><au>Lindstedt, G.</au><au>Mobacken, H.</au><au>Swolin, B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Conventional malabsorption tests: Do they detect the adult patient with villous atrophy?</atitle><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle><addtitle>Scand J Clin Lab Invest</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>44</volume><issue>1</issue><spage>91</spage><epage>98</epage><pages>91-98</pages><issn>0036-5513</issn><eissn>1502-7686</eissn><coden>SJCLAY</coden><abstract>Gillberg, R., Dotevall, G., Kastrup, W., Lindstedt, G., Mobacken, H. & Swolin, B. Conventional malabsorption tests: do they detect the adult patient with villous atrophy?
A total number of 134 patients with subtotal or partial villous atrophy, of whom 49 had dermatitis herpetiformis, were investigated with blood folate assay and xylose and lactose absorption tests. Faecal fat excretion was determined in 71 patients without dermatitis herpetiformis (coeliac group). A comparison was made between three patient groups, the patients with dermatitis herpetiformis and the coeliac patients studied in 1970-74 and 1975-79, respectively. From clinical and biochemical analyses of these patients we conclude that although a combination of the four malabsorption tests used here still detect a majority of coeliac patients, small intestinal biopsy may reveal villous atrophy also in patients without any laboratory evidence for malabsorption by these commonly used tests. In dermatitis herpetiformis, however, the sensitivity of the tests used was low; these malabsorption tests therefore have little diagnostic value in this category of patients.</abstract><cop>Oslo</cop><pub>Informa UK Ltd</pub><pmid>6701455</pmid><doi>10.3109/00365518409083792</doi><tpages>8</tpages></addata></record> |
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| ispartof | Scandinavian journal of clinical and laboratory investigation, 1984-01, Vol.44 (1), p.91-98 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Aged Atrophy Biological and medical sciences Celiac Disease - pathology coeliac disease dermatitis herpetiformis Dermatitis Herpetiformis - pathology faecal fat determination Female folate assay Folic Acid - blood Gastroenterology. Liver. Pancreas. Abdomen Humans Intestines - pathology Lactose lactose absorption test malabsorption Malabsorption Syndromes - diagnosis Male Medical sciences Middle Aged Other diseases. Semiology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus test sensitivity villous atrophy Xylose xylose test |
| title | Conventional malabsorption tests: Do they detect the adult patient with villous atrophy? |
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