Cytotoxic effects of alloxan treatment in vitro on monolayer cultures of neonatal rat pancreas

K. C. Gorray, D. G. Baskin and W. Y. Fujimoto Monolayer cultures of neonatal rat pancreas were exposed briefly (5 min) to alloxan and were then maintained for several days (up to 14 days) to examine the long-term effects of alloxan exposure on B cells. Alloxan (0-10 mM) caused a dose-dependent reduc...

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Veröffentlicht in:	American journal of physiology: endocrinology and metabolism 1983-10, Vol.245 (4), p.E417-E423
Hauptverfasser:	Gorray, K. C, Baskin, D. G, Fujimoto, W. Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan - toxicity Animals Animals, Newborn Biological and medical sciences Cells, Cultured Culture Media Diabetes. Impaired glucose tolerance Dose-Response Relationship, Drug Endocrine pancreas. Apud cells (diseases) Endocrinopathies Glucagon - metabolism Glucose - pharmacology Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - metabolism Kinetics Medical sciences Rats Rats, Inbred Strains
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