Transforming growth factor‐β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

BACKGROUND Transforming growth factor‐β1 (TGF‐ β1) is a multifunctional factor and is known to affect tumor growth in malignant tumors. The effects of TGF‐β1 on angiogenesis, stromal formation, and immune function suggest its possible involvement in tumor progression. The authors examined whether TG...

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Veröffentlicht in:Cancer 2001-03, Vol.91 (5), p.964-971
Hauptverfasser: Hasegawa, Yukihiro, Takanashi, Shingo, Kanehira, Yutaka, Tsushima, Takao, Imai, Tadashi, Okumura, Ken
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container_end_page 971
container_issue 5
container_start_page 964
container_title Cancer
container_volume 91
creator Hasegawa, Yukihiro
Takanashi, Shingo
Kanehira, Yutaka
Tsushima, Takao
Imai, Tadashi
Okumura, Ken
description BACKGROUND Transforming growth factor‐β1 (TGF‐ β1) is a multifunctional factor and is known to affect tumor growth in malignant tumors. The effects of TGF‐β1 on angiogenesis, stromal formation, and immune function suggest its possible involvement in tumor progression. The authors examined whether TGF‐β1 levels may be correlated with angiogenesis, clinicopathologic factors, and survival in patients with surgically resected lung carcinoma. METHODS TGF‐β1 protein was extracted from 53 nonsmall cell lung carcinoma tissue samples (19 squamous cell carcinomas, 33 adenocarcinomas, and 1 adenosquamous cell carcinoma), and its level was measured by enzyme‐linked immunosorbent assay. To assess tumor angiogenesis, microvessel density (MVD) was determined by CD31 immunostaining. RESULTS The protein level of TGF‐β1 was 289 picograms per milligram of protein (pg/mg protein), ranging from 94 pg/mg protein to 584 pg/mg protein. The TGF‐β1 protein level was significantly higher in patients with lymph node metastasis compared with patients who were without lymph node metastasis (P = 0.02), and the TGF‐β1 protein level was significantly higher in patients with Stage III disease (TNM classification) compared with patients who had Stage I and II disease (P = 0.03). There was no significant correlation between the TGF‐β1 protein level and any of the other clinicopathologic factors that were considered. A significant positive correlation between TGF‐β1 protein level and MVD was noted (P < 0.01). Furthermore, in patients with adenocarcinoma, a significant correlation between TGF‐β1 protein level and prognosis was detected by multivariate analysis (P = 0.028). CONCLUSIONS TGF‐β1 seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, the TGF‐β1 protein level may be an independent predictor of survival in patients with adenocarcinoma of the lung. Cancer 2001;91:964–71. © 2001 American Cancer Society. Transforming growth factor‐β1 (TGF‐β1) seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, TGF‐β1 levels may be an independent predictor of survival in patients with lung adenocarcinoma.
doi_str_mv 10.1002/1097-0142(20010301)91:5<964::AID-CNCR1086>3.0.CO;2-O
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The effects of TGF‐β1 on angiogenesis, stromal formation, and immune function suggest its possible involvement in tumor progression. The authors examined whether TGF‐β1 levels may be correlated with angiogenesis, clinicopathologic factors, and survival in patients with surgically resected lung carcinoma. METHODS TGF‐β1 protein was extracted from 53 nonsmall cell lung carcinoma tissue samples (19 squamous cell carcinomas, 33 adenocarcinomas, and 1 adenosquamous cell carcinoma), and its level was measured by enzyme‐linked immunosorbent assay. To assess tumor angiogenesis, microvessel density (MVD) was determined by CD31 immunostaining. RESULTS The protein level of TGF‐β1 was 289 picograms per milligram of protein (pg/mg protein), ranging from 94 pg/mg protein to 584 pg/mg protein. The TGF‐β1 protein level was significantly higher in patients with lymph node metastasis compared with patients who were without lymph node metastasis (P = 0.02), and the TGF‐β1 protein level was significantly higher in patients with Stage III disease (TNM classification) compared with patients who had Stage I and II disease (P = 0.03). There was no significant correlation between the TGF‐β1 protein level and any of the other clinicopathologic factors that were considered. A significant positive correlation between TGF‐β1 protein level and MVD was noted (P &lt; 0.01). Furthermore, in patients with adenocarcinoma, a significant correlation between TGF‐β1 protein level and prognosis was detected by multivariate analysis (P = 0.028). CONCLUSIONS TGF‐β1 seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, the TGF‐β1 protein level may be an independent predictor of survival in patients with adenocarcinoma of the lung. Cancer 2001;91:964–71. © 2001 American Cancer Society. Transforming growth factor‐β1 (TGF‐β1) seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, TGF‐β1 levels may be an independent predictor of survival in patients with lung adenocarcinoma.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(20010301)91:5&lt;964::AID-CNCR1086&gt;3.0.CO;2-O</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>New York: John Wiley &amp; Sons, Inc</publisher><subject>angiogenesis ; Biological and medical sciences ; lung carcinoma ; Medical sciences ; microvessel count ; Pneumology ; prognosis ; transforming growth factor‐β1 ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer, 2001-03, Vol.91 (5), p.964-971</ispartof><rights>Copyright © 2001 American Cancer Society</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1097-0142%2820010301%2991%3A5%3C964%3A%3AAID-CNCR1086%3E3.0.CO%3B2-O$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1097-0142%2820010301%2991%3A5%3C964%3A%3AAID-CNCR1086%3E3.0.CO%3B2-O$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=948257$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Hasegawa, Yukihiro</creatorcontrib><creatorcontrib>Takanashi, Shingo</creatorcontrib><creatorcontrib>Kanehira, Yutaka</creatorcontrib><creatorcontrib>Tsushima, Takao</creatorcontrib><creatorcontrib>Imai, Tadashi</creatorcontrib><creatorcontrib>Okumura, Ken</creatorcontrib><title>Transforming growth factor‐β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma</title><title>Cancer</title><description>BACKGROUND Transforming growth factor‐β1 (TGF‐ β1) is a multifunctional factor and is known to affect tumor growth in malignant tumors. The effects of TGF‐β1 on angiogenesis, stromal formation, and immune function suggest its possible involvement in tumor progression. The authors examined whether TGF‐β1 levels may be correlated with angiogenesis, clinicopathologic factors, and survival in patients with surgically resected lung carcinoma. METHODS TGF‐β1 protein was extracted from 53 nonsmall cell lung carcinoma tissue samples (19 squamous cell carcinomas, 33 adenocarcinomas, and 1 adenosquamous cell carcinoma), and its level was measured by enzyme‐linked immunosorbent assay. To assess tumor angiogenesis, microvessel density (MVD) was determined by CD31 immunostaining. RESULTS The protein level of TGF‐β1 was 289 picograms per milligram of protein (pg/mg protein), ranging from 94 pg/mg protein to 584 pg/mg protein. The TGF‐β1 protein level was significantly higher in patients with lymph node metastasis compared with patients who were without lymph node metastasis (P = 0.02), and the TGF‐β1 protein level was significantly higher in patients with Stage III disease (TNM classification) compared with patients who had Stage I and II disease (P = 0.03). There was no significant correlation between the TGF‐β1 protein level and any of the other clinicopathologic factors that were considered. A significant positive correlation between TGF‐β1 protein level and MVD was noted (P &lt; 0.01). Furthermore, in patients with adenocarcinoma, a significant correlation between TGF‐β1 protein level and prognosis was detected by multivariate analysis (P = 0.028). CONCLUSIONS TGF‐β1 seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, the TGF‐β1 protein level may be an independent predictor of survival in patients with adenocarcinoma of the lung. Cancer 2001;91:964–71. © 2001 American Cancer Society. Transforming growth factor‐β1 (TGF‐β1) seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, TGF‐β1 levels may be an independent predictor of survival in patients with lung adenocarcinoma.</description><subject>angiogenesis</subject><subject>Biological and medical sciences</subject><subject>lung carcinoma</subject><subject>Medical sciences</subject><subject>microvessel count</subject><subject>Pneumology</subject><subject>prognosis</subject><subject>transforming growth factor‐β1</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNo9kd2K1TAQx4soeFx9h4A3Ctvj5KNtclyEpeq6sFiQFfQqzLZpjbRJSboe9s5HEHwTH8SH2CfZnP04NwmZ_GYG_r8sO6KwpgDsDQVV5UAFe8UAKHCgrxXdFEeqFJvN8en7vP5cf6Egy3d8Deu6ecvy5lG22rc9zlYAIPNC8G9Ps2cx_kzPihV8lf09D-hi78Nk3UCG4LfLD9Jju_hw_fvP_3-UjOaXGUnrQzAjLiaSrU0IusH6wTgTbTwky-XkA5mDH4KJ0Xp3mIDutuB8Ioh1ZMbFGrfc9zvv4oRjGmzSMV6m5S2G1jo_4fPsSY9jNC_u74Ps68cP5_Wn_Kw5Oa2Pz_KZVrLMqQAoTaXQdCmlCoS4qCSVHQKXqLAvFUhZSBQFdp1QZaEkU6ri4kJ1zPSKH2Qv7-bOGFsc-5REa6Oeg50wXGklJCuqRH2_o7Z2NFf7Xwp650bvQta7kPWDG62oLnRyo5Ma_aBGcw26bjTTzb7GbwB_jI3p</recordid><startdate>20010301</startdate><enddate>20010301</enddate><creator>Hasegawa, Yukihiro</creator><creator>Takanashi, Shingo</creator><creator>Kanehira, Yutaka</creator><creator>Tsushima, Takao</creator><creator>Imai, Tadashi</creator><creator>Okumura, Ken</creator><general>John Wiley &amp; Sons, Inc</general><general>Wiley-Liss</general><scope>IQODW</scope></search><sort><creationdate>20010301</creationdate><title>Transforming growth factor‐β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma</title><author>Hasegawa, Yukihiro ; Takanashi, Shingo ; Kanehira, Yutaka ; Tsushima, Takao ; Imai, Tadashi ; Okumura, Ken</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1786-14006e79aed1007044b7818da038a9af6908858a45add496598299734b9d2ef93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>angiogenesis</topic><topic>Biological and medical sciences</topic><topic>lung carcinoma</topic><topic>Medical sciences</topic><topic>microvessel count</topic><topic>Pneumology</topic><topic>prognosis</topic><topic>transforming growth factor‐β1</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hasegawa, Yukihiro</creatorcontrib><creatorcontrib>Takanashi, Shingo</creatorcontrib><creatorcontrib>Kanehira, Yutaka</creatorcontrib><creatorcontrib>Tsushima, Takao</creatorcontrib><creatorcontrib>Imai, Tadashi</creatorcontrib><creatorcontrib>Okumura, Ken</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hasegawa, Yukihiro</au><au>Takanashi, Shingo</au><au>Kanehira, Yutaka</au><au>Tsushima, Takao</au><au>Imai, Tadashi</au><au>Okumura, Ken</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transforming growth factor‐β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma</atitle><jtitle>Cancer</jtitle><date>2001-03-01</date><risdate>2001</risdate><volume>91</volume><issue>5</issue><spage>964</spage><epage>971</epage><pages>964-971</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND Transforming growth factor‐β1 (TGF‐ β1) is a multifunctional factor and is known to affect tumor growth in malignant tumors. The effects of TGF‐β1 on angiogenesis, stromal formation, and immune function suggest its possible involvement in tumor progression. The authors examined whether TGF‐β1 levels may be correlated with angiogenesis, clinicopathologic factors, and survival in patients with surgically resected lung carcinoma. METHODS TGF‐β1 protein was extracted from 53 nonsmall cell lung carcinoma tissue samples (19 squamous cell carcinomas, 33 adenocarcinomas, and 1 adenosquamous cell carcinoma), and its level was measured by enzyme‐linked immunosorbent assay. To assess tumor angiogenesis, microvessel density (MVD) was determined by CD31 immunostaining. RESULTS The protein level of TGF‐β1 was 289 picograms per milligram of protein (pg/mg protein), ranging from 94 pg/mg protein to 584 pg/mg protein. The TGF‐β1 protein level was significantly higher in patients with lymph node metastasis compared with patients who were without lymph node metastasis (P = 0.02), and the TGF‐β1 protein level was significantly higher in patients with Stage III disease (TNM classification) compared with patients who had Stage I and II disease (P = 0.03). There was no significant correlation between the TGF‐β1 protein level and any of the other clinicopathologic factors that were considered. A significant positive correlation between TGF‐β1 protein level and MVD was noted (P &lt; 0.01). Furthermore, in patients with adenocarcinoma, a significant correlation between TGF‐β1 protein level and prognosis was detected by multivariate analysis (P = 0.028). CONCLUSIONS TGF‐β1 seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, the TGF‐β1 protein level may be an independent predictor of survival in patients with adenocarcinoma of the lung. Cancer 2001;91:964–71. © 2001 American Cancer Society. Transforming growth factor‐β1 (TGF‐β1) seems to affect tumor angiogenesis and to play an important role in tumor progression in patients with nonsmall cell lung carcinoma. Furthermore, TGF‐β1 levels may be an independent predictor of survival in patients with lung adenocarcinoma.</abstract><cop>New York</cop><pub>John Wiley &amp; Sons, Inc</pub><doi>10.1002/1097-0142(20010301)91:5&lt;964::AID-CNCR1086&gt;3.0.CO;2-O</doi><tpages>8</tpages></addata></record>
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source Wiley Online Library Journals Frontfile Complete; Wiley Free Content; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects angiogenesis
Biological and medical sciences
lung carcinoma
Medical sciences
microvessel count
Pneumology
prognosis
transforming growth factor‐β1
Tumors of the respiratory system and mediastinum
title Transforming growth factor‐β1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma
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