Gas Chromatographic Determination of Nordihydroguaiaretic Acid in Larrea Divaricata
A glc analysis method utilizing a flame ionization detector was developed to determine nordihydroguaiaretic acid (NDGA). Lyophilized samples of an aqueous extract from leaves of L. divaricata were reconstituted in water at a concentration of 50 mg/ml. A 100 mcl aliquot of this solution had 50 mcl of...
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| Veröffentlicht in: | Analytical letters 1984-01, Vol.17 (14), p.1617-1626 |
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| container_title | Analytical letters |
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| creator | Valentine, J. L. McKenzie, Larry Kovarik, Frances |
| description | A glc analysis method utilizing a flame ionization detector was developed to determine nordihydroguaiaretic acid (NDGA). Lyophilized samples of an aqueous extract from leaves of
L. divaricata
were reconstituted in water at a concentration of 50 mg/ml. A 100 mcl aliquot of this solution had 50 mcl of the internal standard solution, p,p'-biphenol (0.4 mg/ml in methanol) added followed by extraction with benzene:isopropyl alcohol (98:2), evaporation, and trimethylsilylation with N,O-bis-(trimethylsilyl)-acetamide. Glc analysis was accomplished using a 10% OV-101 on 80/100 Gas Chrom Q column. Accuracy and precision for the glc method was demonstrated over the range of anticipated concentration of NDGA in the
L. divaricata
leaves. The content of NDGA present in the leaves was found to be 1.6%. |
| doi_str_mv | 10.1080/00032718408065335 |
| format | Article |
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L. divaricata
were reconstituted in water at a concentration of 50 mg/ml. A 100 mcl aliquot of this solution had 50 mcl of the internal standard solution, p,p'-biphenol (0.4 mg/ml in methanol) added followed by extraction with benzene:isopropyl alcohol (98:2), evaporation, and trimethylsilylation with N,O-bis-(trimethylsilyl)-acetamide. Glc analysis was accomplished using a 10% OV-101 on 80/100 Gas Chrom Q column. Accuracy and precision for the glc method was demonstrated over the range of anticipated concentration of NDGA in the
L. divaricata
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L. divaricata
were reconstituted in water at a concentration of 50 mg/ml. A 100 mcl aliquot of this solution had 50 mcl of the internal standard solution, p,p'-biphenol (0.4 mg/ml in methanol) added followed by extraction with benzene:isopropyl alcohol (98:2), evaporation, and trimethylsilylation with N,O-bis-(trimethylsilyl)-acetamide. Glc analysis was accomplished using a 10% OV-101 on 80/100 Gas Chrom Q column. Accuracy and precision for the glc method was demonstrated over the range of anticipated concentration of NDGA in the
L. divaricata
leaves. The content of NDGA present in the leaves was found to be 1.6%.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Glc</subject><subject>L. divaricata</subject><subject>Medical sciences</subject><subject>Nordihydroguaiaretic acid</subject><subject>Pharmacology. Drug treatments</subject><subject>stability</subject><issn>0003-2719</issn><issn>1532-236X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNp1kE1Lw0AQhhdRsFZ_gLccvEZ3d7L5AC-ltVUoelDBWxj3o11JsmU2Kv33plS9iKfhZZ5nBl7GzgW_FLzkV5xzkIUosyHkCkAdsJFQIFMJ-cshG-326QBUx-wkxjfOhSylGLHHBcZkuqbQYh9WhJu118nM9pZa32HvQ5cEl9wHMn69NRRW7-iRbD9QE-1N4rtkiUQWk5n_QPIaezxlRw6baM--55g9z2-eprfp8mFxN50sUw1S9alVr9ZZJZ3SOTjuZGEtSCtLXYrMmMyVTlpQYDhUFSqsAAsrs7zKS5kbdDBmYn9XU4iRrKs35FukbS14vWul_tPK4FzsnQ1GjY0j7LSPv2IlRQFZNmDXe8x3LlCLn4EaU_e4bQL9OPD_ly-oTnUt</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Valentine, J. L.</creator><creator>McKenzie, Larry</creator><creator>Kovarik, Frances</creator><general>Taylor & Francis Group</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19840101</creationdate><title>Gas Chromatographic Determination of Nordihydroguaiaretic Acid in Larrea Divaricata</title><author>Valentine, J. L. ; McKenzie, Larry ; Kovarik, Frances</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-e5befe52f5c63f0f27ee32e28c814dd4f8f2e353d0399a5a93a7e24696826daf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Glc</topic><topic>L. divaricata</topic><topic>Medical sciences</topic><topic>Nordihydroguaiaretic acid</topic><topic>Pharmacology. Drug treatments</topic><topic>stability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valentine, J. L.</creatorcontrib><creatorcontrib>McKenzie, Larry</creatorcontrib><creatorcontrib>Kovarik, Frances</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Analytical letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valentine, J. L.</au><au>McKenzie, Larry</au><au>Kovarik, Frances</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gas Chromatographic Determination of Nordihydroguaiaretic Acid in Larrea Divaricata</atitle><jtitle>Analytical letters</jtitle><date>1984-01-01</date><risdate>1984</risdate><volume>17</volume><issue>14</issue><spage>1617</spage><epage>1626</epage><pages>1617-1626</pages><issn>0003-2719</issn><eissn>1532-236X</eissn><coden>ANALBP</coden><abstract>A glc analysis method utilizing a flame ionization detector was developed to determine nordihydroguaiaretic acid (NDGA). Lyophilized samples of an aqueous extract from leaves of
L. divaricata
were reconstituted in water at a concentration of 50 mg/ml. A 100 mcl aliquot of this solution had 50 mcl of the internal standard solution, p,p'-biphenol (0.4 mg/ml in methanol) added followed by extraction with benzene:isopropyl alcohol (98:2), evaporation, and trimethylsilylation with N,O-bis-(trimethylsilyl)-acetamide. Glc analysis was accomplished using a 10% OV-101 on 80/100 Gas Chrom Q column. Accuracy and precision for the glc method was demonstrated over the range of anticipated concentration of NDGA in the
L. divaricata
leaves. The content of NDGA present in the leaves was found to be 1.6%.</abstract><cop>Philadelphia, PA</cop><pub>Taylor & Francis Group</pub><doi>10.1080/00032718408065335</doi><tpages>10</tpages></addata></record> |
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| ispartof | Analytical letters, 1984-01, Vol.17 (14), p.1617-1626 |
| issn | 0003-2719 1532-236X |
| language | eng |
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| subjects | Analysis Biological and medical sciences General pharmacology Glc L. divaricata Medical sciences Nordihydroguaiaretic acid Pharmacology. Drug treatments stability |
| title | Gas Chromatographic Determination of Nordihydroguaiaretic Acid in Larrea Divaricata |
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