High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device
A normal-phase high-performance liquid chromatographic method was used for the determination of methyl carboprost and acid-catalyzed degradation products in a polymer-based, controlled release dosage form. A reversed-phase method was used to isolate sufficient quantities of the degradation products...
Gespeichert in:
| Veröffentlicht in: | Journal of chromatography 1984-11, Vol.314, p.369-377 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 377 |
|---|---|
| container_issue | |
| container_start_page | 369 |
| container_title | Journal of chromatography |
| container_volume | 314 |
| creator | PLAISTED, S. M DEZWAAN, J SNIDER, B. G |
| description | A normal-phase high-performance liquid chromatographic method was used for the determination of methyl carboprost and acid-catalyzed degradation products in a polymer-based, controlled release dosage form. A reversed-phase method was used to isolate sufficient quantities of the degradation products to determine their identity. Degradation of methyl carboprost under acidic conditions results in epimerization and dehydration, to several isomers, at the tertiary allylic hydroxyl group. Mass balance was 94% for a sample allowed to degrade 50%. These compounds were observed to form in the polymer-based, controlled release dosage form. For the determination of methyl carboprost in the dosage form, the method was found to be linear, precise with a relative standard deviation of 2% and to have an average recovery of 99.2%. |
| doi_str_mv | 10.1016/S0021-9673(01)97749-0 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_9200090</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>6526887</sourcerecordid><originalsourceid>FETCH-LOGICAL-p136t-dd1f90988bf13d6703f64a0fbba06e5f4b70d97e7e90811622da4f368b57d423</originalsourceid><addsrcrecordid>eNo9kM1KxDAUhbNQ_H8EIQsXuqjetJ2kWcqgjiC40L3cJjdOJG1qmhHqo_i0VmZwdeB8H2dxGDsXcC1AyJsXgFIUWqrqEsSVVqrWBeyxo__6kB2P4weAUKDKA3YgF6VsGnXEflb-fV0MlFxMHfaGePCfG2-5WafYYY7vCYe1N9xSptT5HrOPPY-Oo_G2MJgxTN9kZz6bdkuHFO3G5PFP6yivp8ANpjbO_Zi57znyIYapozQPm9jnFEMgWyQKhCPNW1_e0CnbdxhGOtvlCXu9v3tdroqn54fH5e1TMYhK5sJa4TTopmmdqKxUUDlZI7i2RZC0cHWrwGpFijQ0QsiytFi7SjbtQtm6rE7Y-XZ22LQd2bch-Q7T9La7aOYXO46jweDS_JIf_zVdAoCG6hcWSXkw</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>PLAISTED, S. M ; DEZWAAN, J ; SNIDER, B. G</creator><creatorcontrib>PLAISTED, S. M ; DEZWAAN, J ; SNIDER, B. G</creatorcontrib><description>A normal-phase high-performance liquid chromatographic method was used for the determination of methyl carboprost and acid-catalyzed degradation products in a polymer-based, controlled release dosage form. A reversed-phase method was used to isolate sufficient quantities of the degradation products to determine their identity. Degradation of methyl carboprost under acidic conditions results in epimerization and dehydration, to several isomers, at the tertiary allylic hydroxyl group. Mass balance was 94% for a sample allowed to degrade 50%. These compounds were observed to form in the polymer-based, controlled release dosage form. For the determination of methyl carboprost in the dosage form, the method was found to be linear, precise with a relative standard deviation of 2% and to have an average recovery of 99.2%.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/S0021-9673(01)97749-0</identifier><identifier>PMID: 6526887</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Biological and medical sciences ; Carboprost - analysis ; Chemical Phenomena ; Chemistry ; Chromatography, High Pressure Liquid - methods ; Drug Stability ; General pharmacology ; Hydrogen-Ion Concentration ; Medical sciences ; Membranes, Artificial ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Polymers ; Prostaglandins F, Synthetic - analysis</subject><ispartof>Journal of chromatography, 1984-11, Vol.314, p.369-377</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9200090$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6526887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PLAISTED, S. M</creatorcontrib><creatorcontrib>DEZWAAN, J</creatorcontrib><creatorcontrib>SNIDER, B. G</creatorcontrib><title>High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device</title><title>Journal of chromatography</title><addtitle>J Chromatogr</addtitle><description>A normal-phase high-performance liquid chromatographic method was used for the determination of methyl carboprost and acid-catalyzed degradation products in a polymer-based, controlled release dosage form. A reversed-phase method was used to isolate sufficient quantities of the degradation products to determine their identity. Degradation of methyl carboprost under acidic conditions results in epimerization and dehydration, to several isomers, at the tertiary allylic hydroxyl group. Mass balance was 94% for a sample allowed to degrade 50%. These compounds were observed to form in the polymer-based, controlled release dosage form. For the determination of methyl carboprost in the dosage form, the method was found to be linear, precise with a relative standard deviation of 2% and to have an average recovery of 99.2%.</description><subject>Biological and medical sciences</subject><subject>Carboprost - analysis</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Drug Stability</subject><subject>General pharmacology</subject><subject>Hydrogen-Ion Concentration</subject><subject>Medical sciences</subject><subject>Membranes, Artificial</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymers</subject><subject>Prostaglandins F, Synthetic - analysis</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1KxDAUhbNQ_H8EIQsXuqjetJ2kWcqgjiC40L3cJjdOJG1qmhHqo_i0VmZwdeB8H2dxGDsXcC1AyJsXgFIUWqrqEsSVVqrWBeyxo__6kB2P4weAUKDKA3YgF6VsGnXEflb-fV0MlFxMHfaGePCfG2-5WafYYY7vCYe1N9xSptT5HrOPPY-Oo_G2MJgxTN9kZz6bdkuHFO3G5PFP6yivp8ANpjbO_Zi57znyIYapozQPm9jnFEMgWyQKhCPNW1_e0CnbdxhGOtvlCXu9v3tdroqn54fH5e1TMYhK5sJa4TTopmmdqKxUUDlZI7i2RZC0cHWrwGpFijQ0QsiytFi7SjbtQtm6rE7Y-XZ22LQd2bch-Q7T9La7aOYXO46jweDS_JIf_zVdAoCG6hcWSXkw</recordid><startdate>19841130</startdate><enddate>19841130</enddate><creator>PLAISTED, S. M</creator><creator>DEZWAAN, J</creator><creator>SNIDER, B. G</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19841130</creationdate><title>High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device</title><author>PLAISTED, S. M ; DEZWAAN, J ; SNIDER, B. G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p136t-dd1f90988bf13d6703f64a0fbba06e5f4b70d97e7e90811622da4f368b57d423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Biological and medical sciences</topic><topic>Carboprost - analysis</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Drug Stability</topic><topic>General pharmacology</topic><topic>Hydrogen-Ion Concentration</topic><topic>Medical sciences</topic><topic>Membranes, Artificial</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymers</topic><topic>Prostaglandins F, Synthetic - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PLAISTED, S. M</creatorcontrib><creatorcontrib>DEZWAAN, J</creatorcontrib><creatorcontrib>SNIDER, B. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Journal of chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PLAISTED, S. M</au><au>DEZWAAN, J</au><au>SNIDER, B. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device</atitle><jtitle>Journal of chromatography</jtitle><addtitle>J Chromatogr</addtitle><date>1984-11-30</date><risdate>1984</risdate><volume>314</volume><spage>369</spage><epage>377</epage><pages>369-377</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>A normal-phase high-performance liquid chromatographic method was used for the determination of methyl carboprost and acid-catalyzed degradation products in a polymer-based, controlled release dosage form. A reversed-phase method was used to isolate sufficient quantities of the degradation products to determine their identity. Degradation of methyl carboprost under acidic conditions results in epimerization and dehydration, to several isomers, at the tertiary allylic hydroxyl group. Mass balance was 94% for a sample allowed to degrade 50%. These compounds were observed to form in the polymer-based, controlled release dosage form. For the determination of methyl carboprost in the dosage form, the method was found to be linear, precise with a relative standard deviation of 2% and to have an average recovery of 99.2%.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>6526887</pmid><doi>10.1016/S0021-9673(01)97749-0</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9673 |
| ispartof | Journal of chromatography, 1984-11, Vol.314, p.369-377 |
| issn | 0021-9673 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_9200090 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences Carboprost - analysis Chemical Phenomena Chemistry Chromatography, High Pressure Liquid - methods Drug Stability General pharmacology Hydrogen-Ion Concentration Medical sciences Membranes, Artificial Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers Prostaglandins F, Synthetic - analysis |
| title | High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T03%3A48%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High-performance%20liquid%20chromatographic%20determination%20of%20acid-catalyzed%20degradation%20products%20of%20methyl%20carboprost%20in%20a%20polymeric%20controlled-release%20device&rft.jtitle=Journal%20of%20chromatography&rft.au=PLAISTED,%20S.%20M&rft.date=1984-11-30&rft.volume=314&rft.spage=369&rft.epage=377&rft.pages=369-377&rft.issn=0021-9673&rft.coden=JOCRAM&rft_id=info:doi/10.1016/S0021-9673(01)97749-0&rft_dat=%3Cpubmed_pasca%3E6526887%3C/pubmed_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/6526887&rfr_iscdi=true |