Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo(a)pyrene

Rapidly growing primary cultures of normal human mammary epithelial cells (HMEC) were exposed to 1 μ g of benzo[a]pyrene (B[a]P) per ml for two or three 24-hr periods. The B[a]P-treated populations consistently contained cells displaying a longer period of active growth in culture compared to the un...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1985-04, Vol.82 (8), p.2394-2398
Hauptverfasser:	Stampfer, M.R, Bartley, J.C
Format:	Artikel
Sprache:	eng
Schlagworte:	560301 - Chemicals Metabolism & Toxicology- Cells- (-1987) AIR POLLUTION ANIMAL TISSUES AROMATICS Benzo(a)pyrene - metabolism Benzo(a)pyrene - toxicity BENZOPYRENE Biological and medical sciences BIOLOGICAL EFFECTS BODY Breast - cytology Breast - drug effects Breast - metabolism CARCINOGENESIS CARCINOGENOS CARCINOGENS Cell culture techniques CELL CULTURES CELL DIFFERENTIATION Cell Division Cell growth Cell Line Cell lines Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic - drug effects CELL TRANSFORMATIONS CELLS Cellular metabolism CELLULE CELULAS CONDENSED AROMATICS CONTAMINACION DEL AIRE CONTAMINANTES Cultured cells CYTOLOGICAL TECHNIQUES Epithelial cells EPITHELIUM Epithelium - drug effects Female Fundamental and applied biological sciences. Psychology GLANDE MAMMAIRE GLANDS GLANDULAS MAMARIAS Glucose - metabolism HUMAN POPULATION Humans HYDROCARBONS Lactates MAMMARY GLANDS Molecular and cellular biology MORPHOLOGICAL CHANGES ONCOGENIC TRANSFORMATIONS ORGANIC COMPOUNDS ORGANS PATHOGENESIS POBLACION HUMANA POLLUANT POLLUTANTS POLLUTION ATMOSPHERIQUE POPULATION HUMAINE RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Subcultures SUBSTANCE CANCERIGENE TISSUES Transformed cell line Tumor cell line
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