Isolation and Biochemical Characterization of the Mammalian Reovirus Type 3 Cell-Surface Receptor

A cell-surface receptor for the mammalian reovirus type 3 hemagglutinin was isolated by using anti-idiotypic anti-receptor antibodies. The receptor is a glycoprotein with a molecular mass of 67,000 daltons and a pI of 5.9. Evidence that the isolated structure represents the reovirus receptor was obt...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1985-03, Vol.82 (5), p.1494-1498
Hauptverfasser:	Co, Man Sung, Gaulton, Glen N., Fields, Bernard N., Greene, Mark I.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AGGLUTININS ANIMAL CELLS Animals ANTIBODIES Antibodies, Anti-Idiotypic - immunology Antibody Specificity BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIOCHEMISTRY Biological and medical sciences BIOLOGICAL MATERIALS BLOOD BLOOD CELLS BODY FLUIDS CARBOHYDRATES CELL CONSTITUENTS Cell Line Cell lines CELL MEMBRANES CHEMISTRY CONNECTIVE TISSUE CELLS DAYS LIVING RADIOISOTOPES ELECTRON CAPTURE RADIOISOTOPES ELECTROPHORESIS Fundamental and applied biological sciences. Psychology Gels GLUCOPROTEINS HEMAGGLUTININS Humans Immunoglobulin Idiotypes - immunology INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES Isoelectric Point ISOTOPE APPLICATIONS ISOTOPES Kinetics LEUKOCYTES LYMPHOCYTES mammalian cells Mammalian orthoreovirus 3 MATERIALS membrane glycoproteins MEMBRANES Mice Microbiology MICROORGANISMS Molecular Weight MONOCLONAL ANTIBODIES Neuroblastoma - metabolism Neurons NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS PARASITES Protein Binding PROTEINS RADIOISOTOPES RADIORECEPTOR ASSAY Rats Receptors Receptors, Virus - isolation & purification Receptors, Virus - physiology Reoviridae reovirus 3 Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains SACCHARIDES SOMATIC CELLS T lymphocytes Thymoma Thymoma - metabolism TRACER TECHNIQUES TUMOR CELLS Virology VIRUSES
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