Transforming growth factor-β1-induced Smad signaling, cell-cycle arrest and apoptosis in hepatoma cells

Transforming growth factor-β1 (TGFβ) is involved in the regulation of liver cell proliferation and apoptosis, and escape of hepatoma cells from the growth restraining signals of TGFβ has been suggested to contribute to tumor development. TGFβ modulates gene transcription by receptor-mediated activat...

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Veröffentlicht in:	Carcinogenesis (New York) 2001-03, Vol.22 (3), p.447-452
Hauptverfasser:	Buenemann, Christoph Lars, Willy, Claudia, Buchmann, Albrecht, Schmiechen, Alexander, Schwarz, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Cdk Chemotherapy cyclin-dependent kinase early growth response α EGRα Erk1/2 extracellular signal-regulated kinases 1/2 M6P/IGF2 mannose-6-phosphate/insulin-like growth factor-II Medical sciences PBS Pharmacology. Drug treatments phosphate buffered saline reverse transcription–polymerase chain reaction RT–PCR SBE Sma and Mad homolog Smad Smad binding element TGFβ TGFβ-inducible early gene TIEG transforming growth factor-β1
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