2-Alkynyl-8-aryl-9-methyladenines as Novel Adenosine Receptor Antagonists:  Their Synthesis and Structure−Activity Relationships toward Hepatic Glucose Production Induced via Agonism of the A2B Receptor

Novel adenosine antagonists, 2-alkynyl-8-aryl-9-methyladenine derivatives, were synthesized as candidate hypoglycemic agents. These analogues were evaluated for inhibitory activity on N-ethylcarboxamidoadenosine (NECA)-induced glucose production in primary cultured rat hepatocytes. In general, aroma...

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Veröffentlicht in:	Journal of medicinal chemistry 2001-01, Vol.44 (2), p.170-179
Hauptverfasser:	Harada, Hitoshi, Asano, Osamu, Hoshino, Yorihisa, Yoshikawa, Seiji, Matsukura, Masayuki, Kabasawa, Yasuhiro, Niijima, Jun, Kotake, Yoshihiko, Watanabe, Nobuhisa, Kawata, Tsutomu, Inoue, Takashi, Horizoe, Tatsuo, Yasuda, Nobuyuki, Minami, Hiroe, Nagata, Kaya, Murakami, Manabu, Nagaoka, Junsaku, Kobayashi, Seiichi, Tanaka, Isao, Abe, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences General and cellular metabolism. Vitamins Medical sciences Pharmacology. Drug treatments
Online-Zugang:	Volltext
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