Purification, Ultrastructure, and Chemical Analysis of Alzheimer Disease Amyloid Plaque Core Protein

Isolation of Alzheimer disease amyloid plaque core protein (APCP) was carried out by repetitive NaDodSO4/EDTA/sucrose extractions and by Ficoll-400 density-gradient centrifugations. The enriched APCP-Ficoll interface was labeled with the fluorochrome thioflavin T and separated from the contaminating...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1986-04, Vol.83 (8), p.2662-2666
Hauptverfasser:	Roher, Alex, Wolfe, David, Palutke, Margarita, KuKuruga, Debra
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimers disease Amino acids Amino Acids - analysis Amyloid - isolation & purification Amyloid - metabolism Amyloid plaque Amyloids Analytical, structural and metabolic biochemistry Biological and medical sciences Brain Chemistry Centrifugation Chemical composition Electron microscopy Flow Cytometry Fundamental and applied biological sciences. Psychology Humans Lipofuscin - isolation & purification Microscopy, Electron Miscellaneous Nerve Tissue Proteins - isolation & purification Nerve Tissue Proteins - metabolism Neurofibrillary tangles Neurons Oxidation Proteins Solubility
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