Molecular Structure of the G· A Base Pair in DNA and Its Implications for the Mechanism of Transversion Mutations

The synthetic deoxydodecamer d(C-G-C-G-A-A-T-T-A-G-C-G) was analyzed by x-ray diffraction methods, and the structure was refined to a residual error of R = 0.17 at 2.5- angstrom resolution (2 σ data) with 83 water molecules located. The sequence crystallizes as a full turn of a B-DNA helix and conta...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1986-04, Vol.83 (8), p.2402-2406
Hauptverfasser:	Brown, Tom, Hunter, William N., Kneale, Geoff, Kennard, Olga
Format:	Artikel
Sprache:	eng
Schlagworte:	Base pair mismatch Biological and medical sciences Crystal structure DNA Electron density Fundamental and applied biological sciences. Psychology Genetic mutation Molecular and cellular biology Molecular genetics Molecules Mutagenesis. Repair Purines Solvents Tautomers
Online-Zugang:	Volltext
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