Noninvasive assessment of cardiac ischemic injury using 87Rb and 23Na MR imaging, 31P MR, and optical spectroscopy
The aim of the study was to compare and analyze different noninvasive indices of cell damage in the isolated pig heart model of regional ischemia. We used 23Na and 87Rb MR imaging to evaluate Na+/K+ balance, 31P MR spectroscopy to measure energetics, and optical spectroscopy to assess oxymyoglobin (...
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| Veröffentlicht in: | Magnetic resonance in medicine 2000-12, Vol.44 (6), p.899-908 |
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| creator | Kupriyanov, V.V. Dai, G. Shaw, R.A. Sun, J. Jilkina, O. Luo, Z. Mantsch, H. Deslauriers, R. |
| description | The aim of the study was to compare and analyze different noninvasive indices of cell damage in the isolated pig heart model of regional ischemia. We used 23Na and 87Rb MR imaging to evaluate Na+/K+ balance, 31P MR spectroscopy to measure energetics, and optical spectroscopy to assess oxymyoglobin (MbO2). Hearts were subjected to 120‐min occlusion of the left anterior descending artery and were then reperfused for 120 min. Reperfusion resulted in an increase in 23Na (37 ± 18% of the posterior wall) and decrease in 87Rb (55 ± 15%) image intensities, partial recovery of PCr, ATP, the total phosphates, and MbO2 in the anterior wall. The above changes are consistent with the irreversible cell damage in the anterior wall, confirmed by lack of staining with triphenyltetrazolium chloride. Changes in Na+ and Rb+ in the infarct area inversely correlated and their ratio is a more sensitive index of cell injury than either of them alone. Magn Reson Med 44:899–908, 2000. Published 2000 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/1522-2594(200012)44:6<899::AID-MRM11>3.0.CO;2-7 |
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We used 23Na and 87Rb MR imaging to evaluate Na+/K+ balance, 31P MR spectroscopy to measure energetics, and optical spectroscopy to assess oxymyoglobin (MbO2). Hearts were subjected to 120‐min occlusion of the left anterior descending artery and were then reperfused for 120 min. Reperfusion resulted in an increase in 23Na (37 ± 18% of the posterior wall) and decrease in 87Rb (55 ± 15%) image intensities, partial recovery of PCr, ATP, the total phosphates, and MbO2 in the anterior wall. The above changes are consistent with the irreversible cell damage in the anterior wall, confirmed by lack of staining with triphenyltetrazolium chloride. Changes in Na+ and Rb+ in the infarct area inversely correlated and their ratio is a more sensitive index of cell injury than either of them alone. Magn Reson Med 44:899–908, 2000. Published 2000 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/1522-2594(200012)44:6<899::AID-MRM11>3.0.CO;2-7</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Biological and medical sciences ; cardiac ischemia ; Cardiology. Vascular system ; Cardiovascular system ; Coronary heart disease ; Heart ; infarct ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; MR imaging and spectroscopy ; optical spectroscopy ; Radiodiagnosis. Nmr imagery. 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Reson. Med</addtitle><description>The aim of the study was to compare and analyze different noninvasive indices of cell damage in the isolated pig heart model of regional ischemia. We used 23Na and 87Rb MR imaging to evaluate Na+/K+ balance, 31P MR spectroscopy to measure energetics, and optical spectroscopy to assess oxymyoglobin (MbO2). Hearts were subjected to 120‐min occlusion of the left anterior descending artery and were then reperfused for 120 min. Reperfusion resulted in an increase in 23Na (37 ± 18% of the posterior wall) and decrease in 87Rb (55 ± 15%) image intensities, partial recovery of PCr, ATP, the total phosphates, and MbO2 in the anterior wall. The above changes are consistent with the irreversible cell damage in the anterior wall, confirmed by lack of staining with triphenyltetrazolium chloride. Changes in Na+ and Rb+ in the infarct area inversely correlated and their ratio is a more sensitive index of cell injury than either of them alone. Magn Reson Med 44:899–908, 2000. Published 2000 Wiley‐Liss, Inc.</description><subject>Biological and medical sciences</subject><subject>cardiac ischemia</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Coronary heart disease</subject><subject>Heart</subject><subject>infarct</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>MR imaging and spectroscopy</subject><subject>optical spectroscopy</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNo9kGFv0zAQhi0EEmXwHyzxBaSl3NlOnBSENAqMwdpCBZrEl5PtOMOjTaK4G_Tf4y6on3y-9-7R6WFMI0wRQLzCXIhM5JV6IQAAxUulZsWbsqpms7OL99livUB8K6cwna9ei0w_YJPjxkM2Aa0gk1ipx-xJjDeJUFVaTdiw7NrQ3pkY7jw3MfoYt77d8a7hzgx1MI6H6H75bUhFe3M77PltDO01L_XactPWXMil4Ys1D1tznYJTLvFr-p_eh12_C85seOy92w1ddF2_f8oeNWYT_bP_7wn78fHD9_mn7HJ1fjE_u8wCKsDMlgor65qyyLWToAuJBtBihRqEqGqvwNYW6uRCCfC1E9YWzirf6BQrLU_Y85Hbm5huaAbTuhCpH9Klw57KAouyTFPfxqk_YeP3xxSBDtbp4JAODmm0TkpRQck6Jel0L50kAc1XJEiPjcTMRmaIO__3yDTDbyq01DldLc9pgfnPq89fcnon_wEAq4kV</recordid><startdate>200012</startdate><enddate>200012</enddate><creator>Kupriyanov, V.V.</creator><creator>Dai, G.</creator><creator>Shaw, R.A.</creator><creator>Sun, J.</creator><creator>Jilkina, O.</creator><creator>Luo, Z.</creator><creator>Mantsch, H.</creator><creator>Deslauriers, R.</creator><general>John Wiley & Sons, Inc</general><general>Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope></search><sort><creationdate>200012</creationdate><title>Noninvasive assessment of cardiac ischemic injury using 87Rb and 23Na MR imaging, 31P MR, and optical spectroscopy</title><author>Kupriyanov, V.V. ; Dai, G. ; Shaw, R.A. ; Sun, J. ; Jilkina, O. ; Luo, Z. ; Mantsch, H. ; Deslauriers, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i1401-b8419bcf8657c307631a01b19170229de40bdb0d001420edc2bb6cb4ef7229473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Biological and medical sciences</topic><topic>cardiac ischemia</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Coronary heart disease</topic><topic>Heart</topic><topic>infarct</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>MR imaging and spectroscopy</topic><topic>optical spectroscopy</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kupriyanov, V.V.</creatorcontrib><creatorcontrib>Dai, G.</creatorcontrib><creatorcontrib>Shaw, R.A.</creatorcontrib><creatorcontrib>Sun, J.</creatorcontrib><creatorcontrib>Jilkina, O.</creatorcontrib><creatorcontrib>Luo, Z.</creatorcontrib><creatorcontrib>Mantsch, H.</creatorcontrib><creatorcontrib>Deslauriers, R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kupriyanov, V.V.</au><au>Dai, G.</au><au>Shaw, R.A.</au><au>Sun, J.</au><au>Jilkina, O.</au><au>Luo, Z.</au><au>Mantsch, H.</au><au>Deslauriers, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noninvasive assessment of cardiac ischemic injury using 87Rb and 23Na MR imaging, 31P MR, and optical spectroscopy</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2000-12</date><risdate>2000</risdate><volume>44</volume><issue>6</issue><spage>899</spage><epage>908</epage><pages>899-908</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>The aim of the study was to compare and analyze different noninvasive indices of cell damage in the isolated pig heart model of regional ischemia. We used 23Na and 87Rb MR imaging to evaluate Na+/K+ balance, 31P MR spectroscopy to measure energetics, and optical spectroscopy to assess oxymyoglobin (MbO2). Hearts were subjected to 120‐min occlusion of the left anterior descending artery and were then reperfused for 120 min. Reperfusion resulted in an increase in 23Na (37 ± 18% of the posterior wall) and decrease in 87Rb (55 ± 15%) image intensities, partial recovery of PCr, ATP, the total phosphates, and MbO2 in the anterior wall. The above changes are consistent with the irreversible cell damage in the anterior wall, confirmed by lack of staining with triphenyltetrazolium chloride. Changes in Na+ and Rb+ in the infarct area inversely correlated and their ratio is a more sensitive index of cell injury than either of them alone. Magn Reson Med 44:899–908, 2000. Published 2000 Wiley‐Liss, Inc.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1002/1522-2594(200012)44:6<899::AID-MRM11>3.0.CO;2-7</doi><tpages>10</tpages></addata></record> |
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| ispartof | Magnetic resonance in medicine, 2000-12, Vol.44 (6), p.899-908 |
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| source | Wiley Online Library Journals Frontfile Complete; Wiley Free Content |
| subjects | Biological and medical sciences cardiac ischemia Cardiology. Vascular system Cardiovascular system Coronary heart disease Heart infarct Investigative techniques, diagnostic techniques (general aspects) Medical sciences MR imaging and spectroscopy optical spectroscopy Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | Noninvasive assessment of cardiac ischemic injury using 87Rb and 23Na MR imaging, 31P MR, and optical spectroscopy |
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