Stimulation of Aortic Smooth Muscle Cell Mitogenesis by Serotonin
Bovine aortic smooth muscle cells in vitro responded to 1 nM to 10 μ M serotonin with increased incorporation of [3H]thymidine into DNA. The mitogenic effect of serotonin was half-maximal at 80 nM and maximal above 1 μ M. At a concentration of 1 μ M, serotonin stimulated smooth muscle cell mitogenes...
Gespeichert in:
| Veröffentlicht in: | Proc. Natl. Acad. Sci. U.S.A.; (United States) 1986-02, Vol.83 (3), p.674-678 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 678 |
|---|---|
| container_issue | 3 |
| container_start_page | 674 |
| container_title | Proc. Natl. Acad. Sci. U.S.A.; (United States) |
| container_volume | 83 |
| creator | Nemecek, Georgina M. Coughlin, Shaun R. Handley, Dean A. Moskowitz, Michael A. |
| description | Bovine aortic smooth muscle cells in vitro responded to 1 nM to 10 μ M serotonin with increased incorporation of [3H]thymidine into DNA. The mitogenic effect of serotonin was half-maximal at 80 nM and maximal above 1 μ M. At a concentration of 1 μ M, serotonin stimulated smooth muscle cell mitogenesis to the same extent as human platelet-derived growth factor (PDGF) at 12 ng/ml. Tryptamine was ≈ 1/10th as potent as serotonin as a mitogen for smooth muscle cells. Other indoles that are structurally related to serotonin (D-and L-tryptophan, 5-hydroxy-L-tryptophan, N-acetyl-5-hydroxytryptamine, melatonin, 5-hydroxyindoleacetic acid, and 5-hydroxytryptophol) and quipazine were inactive. The stimulatory effect of serotonin on smooth muscle cell DNA synthesis required prolonged (20-24 hr) exposure to the agonist and was attenuated in the presence of serotonin D receptor antagonists. When smooth muscle cells were incubated with submaximal concentrations of serotonin and PDGF, synergistic rather than additive mitogenic responses were observed. These data indicate that serotonin has a significant mitogenic effect on smooth muscle cells in vitro, which appears to be mediated by specific plasma membrane receptors. |
| doi_str_mv | 10.1073/pnas.83.3.674 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_8593208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>27403</jstor_id><sourcerecordid>27403</sourcerecordid><originalsourceid>FETCH-LOGICAL-c573t-1e73c7291be81f583837b187bdce28edb4623df19b0d63bb362a2bbbb24879b73</originalsourceid><addsrcrecordid>eNp9kTuP1DAUhS0EWoaFkgaBFCGgy2D7JrZTUIxGvKRdUQzUlu1xdrxK7FnbQey_x6OJAjTc5hbnO_ehg9BzgtcEc3h_9CqtBaxhzXjzAK0I7kjNmg4_RCuMKa9FQ5vH6ElKtxjjrhX4Al1A0zLCYIU2u-zGaVDZBV-FvtqEmJ2pdmMI-VBdT8kMttraYaiuXQ431tvkUqXvq52NIQfv_FP0qFdDss_mfol-fPr4ffulvvr2-et2c1WblkOuieVgOO2ItoL0rQABXBPB9d5YKuxeN4zCviedxnsGWgOjiupStBG80xwu0Yfz3OOkR1tcPkc1yGN0o4r3Mign_1W8O8ib8FMCpR1lxf_67A8pO5mMy9YcTPDemixZwzGhUKB385IY7iabshxdMuV95W2YkuSMdZS3bQHrM2hiSCnafjmEYHnKRZ5ykQIkyJJL4V_9ff1Cz0EU_c2sq2TU0EfljUsLJtoOKBYFezljp-mL-mfL2__Isp-GIdtfuXAvztxtyiEuIOUNBvgNEO-2eQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76692755</pqid></control><display><type>article</type><title>Stimulation of Aortic Smooth Muscle Cell Mitogenesis by Serotonin</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><creator>Nemecek, Georgina M. ; Coughlin, Shaun R. ; Handley, Dean A. ; Moskowitz, Michael A.</creator><creatorcontrib>Nemecek, Georgina M. ; Coughlin, Shaun R. ; Handley, Dean A. ; Moskowitz, Michael A. ; Sandoz Research Institute, East Hanover, NJ</creatorcontrib><description>Bovine aortic smooth muscle cells in vitro responded to 1 nM to 10 μ M serotonin with increased incorporation of [3H]thymidine into DNA. The mitogenic effect of serotonin was half-maximal at 80 nM and maximal above 1 μ M. At a concentration of 1 μ M, serotonin stimulated smooth muscle cell mitogenesis to the same extent as human platelet-derived growth factor (PDGF) at 12 ng/ml. Tryptamine was ≈ 1/10th as potent as serotonin as a mitogen for smooth muscle cells. Other indoles that are structurally related to serotonin (D-and L-tryptophan, 5-hydroxy-L-tryptophan, N-acetyl-5-hydroxytryptamine, melatonin, 5-hydroxyindoleacetic acid, and 5-hydroxytryptophol) and quipazine were inactive. The stimulatory effect of serotonin on smooth muscle cell DNA synthesis required prolonged (20-24 hr) exposure to the agonist and was attenuated in the presence of serotonin D receptor antagonists. When smooth muscle cells were incubated with submaximal concentrations of serotonin and PDGF, synergistic rather than additive mitogenic responses were observed. These data indicate that serotonin has a significant mitogenic effect on smooth muscle cells in vitro, which appears to be mediated by specific plasma membrane receptors.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.83.3.674</identifier><identifier>PMID: 3456163</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>550301 - Cytology- Tracer Techniques ; AMINES ; ANIMALS ; AORTA ; Aorta - physiology ; AROMATICS ; ARTERIES ; AUTONOMIC NERVOUS SYSTEM AGENTS ; AZAARENES ; AZINES ; AZOLES ; BASIC BIOLOGICAL SCIENCES ; Biological and medical sciences ; BIOLOGICAL EFFECTS ; BLOOD VESSELS ; BODY ; CARDIOVASCULAR SYSTEM ; CATTLE ; CELL DIVISION ; Cell growth ; Cell physiology ; Cultured cells ; DNA ; DNA - biosynthesis ; DOMESTIC ANIMALS ; DOSE-RESPONSE RELATIONSHIPS ; DRUGS ; Fundamental and applied biological sciences. Psychology ; HETEROCYCLIC COMPOUNDS ; Humans ; HYDROXY COMPOUNDS ; IN VITRO ; INDOLES ; LABELLED COMPOUNDS ; MAMMALS ; MITOGENS ; MITOSIS ; Molecular and cellular biology ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - physiology ; MUSCLES ; NEUROREGULATORS ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; ORGANS ; Platelet-Derived Growth Factor - pharmacology ; Platelets ; PYRIMIDINES ; PYRROLES ; RADIOPROTECTIVE SUBSTANCES ; Receptors ; Receptors, Serotonin - drug effects ; Responses to growth factors, tumor promotors, other factors ; RIBOSIDES ; RUMINANTS ; SEROTONIN ; Serotonin - pharmacology ; Serotonin antagonists ; Serotonin Antagonists - pharmacology ; Smooth muscle ; Smooth muscle myocytes ; SYMPATHOMIMETICS ; THYMIDINE ; Thymidine - metabolism ; TRITIUM COMPOUNDS ; TRYPTAMINES ; Ungulates ; VERTEBRATES</subject><ispartof>Proc. Natl. Acad. Sci. U.S.A.; (United States), 1986-02, Vol.83 (3), p.674-678</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-1e73c7291be81f583837b187bdce28edb4623df19b0d63bb362a2bbbb24879b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/83/3.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27403$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27403$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8593208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3456163$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/6470123$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Nemecek, Georgina M.</creatorcontrib><creatorcontrib>Coughlin, Shaun R.</creatorcontrib><creatorcontrib>Handley, Dean A.</creatorcontrib><creatorcontrib>Moskowitz, Michael A.</creatorcontrib><creatorcontrib>Sandoz Research Institute, East Hanover, NJ</creatorcontrib><title>Stimulation of Aortic Smooth Muscle Cell Mitogenesis by Serotonin</title><title>Proc. Natl. Acad. Sci. U.S.A.; (United States)</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Bovine aortic smooth muscle cells in vitro responded to 1 nM to 10 μ M serotonin with increased incorporation of [3H]thymidine into DNA. The mitogenic effect of serotonin was half-maximal at 80 nM and maximal above 1 μ M. At a concentration of 1 μ M, serotonin stimulated smooth muscle cell mitogenesis to the same extent as human platelet-derived growth factor (PDGF) at 12 ng/ml. Tryptamine was ≈ 1/10th as potent as serotonin as a mitogen for smooth muscle cells. Other indoles that are structurally related to serotonin (D-and L-tryptophan, 5-hydroxy-L-tryptophan, N-acetyl-5-hydroxytryptamine, melatonin, 5-hydroxyindoleacetic acid, and 5-hydroxytryptophol) and quipazine were inactive. The stimulatory effect of serotonin on smooth muscle cell DNA synthesis required prolonged (20-24 hr) exposure to the agonist and was attenuated in the presence of serotonin D receptor antagonists. When smooth muscle cells were incubated with submaximal concentrations of serotonin and PDGF, synergistic rather than additive mitogenic responses were observed. These data indicate that serotonin has a significant mitogenic effect on smooth muscle cells in vitro, which appears to be mediated by specific plasma membrane receptors.</description><subject>550301 - Cytology- Tracer Techniques</subject><subject>AMINES</subject><subject>ANIMALS</subject><subject>AORTA</subject><subject>Aorta - physiology</subject><subject>AROMATICS</subject><subject>ARTERIES</subject><subject>AUTONOMIC NERVOUS SYSTEM AGENTS</subject><subject>AZAARENES</subject><subject>AZINES</subject><subject>AZOLES</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and medical sciences</subject><subject>BIOLOGICAL EFFECTS</subject><subject>BLOOD VESSELS</subject><subject>BODY</subject><subject>CARDIOVASCULAR SYSTEM</subject><subject>CATTLE</subject><subject>CELL DIVISION</subject><subject>Cell growth</subject><subject>Cell physiology</subject><subject>Cultured cells</subject><subject>DNA</subject><subject>DNA - biosynthesis</subject><subject>DOMESTIC ANIMALS</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>DRUGS</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>Humans</subject><subject>HYDROXY COMPOUNDS</subject><subject>IN VITRO</subject><subject>INDOLES</subject><subject>LABELLED COMPOUNDS</subject><subject>MAMMALS</subject><subject>MITOGENS</subject><subject>MITOSIS</subject><subject>Molecular and cellular biology</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - physiology</subject><subject>MUSCLES</subject><subject>NEUROREGULATORS</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>ORGANS</subject><subject>Platelet-Derived Growth Factor - pharmacology</subject><subject>Platelets</subject><subject>PYRIMIDINES</subject><subject>PYRROLES</subject><subject>RADIOPROTECTIVE SUBSTANCES</subject><subject>Receptors</subject><subject>Receptors, Serotonin - drug effects</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>RIBOSIDES</subject><subject>RUMINANTS</subject><subject>SEROTONIN</subject><subject>Serotonin - pharmacology</subject><subject>Serotonin antagonists</subject><subject>Serotonin Antagonists - pharmacology</subject><subject>Smooth muscle</subject><subject>Smooth muscle myocytes</subject><subject>SYMPATHOMIMETICS</subject><subject>THYMIDINE</subject><subject>Thymidine - metabolism</subject><subject>TRITIUM COMPOUNDS</subject><subject>TRYPTAMINES</subject><subject>Ungulates</subject><subject>VERTEBRATES</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kTuP1DAUhS0EWoaFkgaBFCGgy2D7JrZTUIxGvKRdUQzUlu1xdrxK7FnbQey_x6OJAjTc5hbnO_ehg9BzgtcEc3h_9CqtBaxhzXjzAK0I7kjNmg4_RCuMKa9FQ5vH6ElKtxjjrhX4Al1A0zLCYIU2u-zGaVDZBV-FvtqEmJ2pdmMI-VBdT8kMttraYaiuXQ431tvkUqXvq52NIQfv_FP0qFdDss_mfol-fPr4ffulvvr2-et2c1WblkOuieVgOO2ItoL0rQABXBPB9d5YKuxeN4zCviedxnsGWgOjiupStBG80xwu0Yfz3OOkR1tcPkc1yGN0o4r3Mign_1W8O8ib8FMCpR1lxf_67A8pO5mMy9YcTPDemixZwzGhUKB385IY7iabshxdMuV95W2YkuSMdZS3bQHrM2hiSCnafjmEYHnKRZ5ykQIkyJJL4V_9ff1Cz0EU_c2sq2TU0EfljUsLJtoOKBYFezljp-mL-mfL2__Isp-GIdtfuXAvztxtyiEuIOUNBvgNEO-2eQ</recordid><startdate>19860201</startdate><enddate>19860201</enddate><creator>Nemecek, Georgina M.</creator><creator>Coughlin, Shaun R.</creator><creator>Handley, Dean A.</creator><creator>Moskowitz, Michael A.</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><scope>5PM</scope></search><sort><creationdate>19860201</creationdate><title>Stimulation of Aortic Smooth Muscle Cell Mitogenesis by Serotonin</title><author>Nemecek, Georgina M. ; Coughlin, Shaun R. ; Handley, Dean A. ; Moskowitz, Michael A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-1e73c7291be81f583837b187bdce28edb4623df19b0d63bb362a2bbbb24879b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>550301 - Cytology- Tracer Techniques</topic><topic>AMINES</topic><topic>ANIMALS</topic><topic>AORTA</topic><topic>Aorta - physiology</topic><topic>AROMATICS</topic><topic>ARTERIES</topic><topic>AUTONOMIC NERVOUS SYSTEM AGENTS</topic><topic>AZAARENES</topic><topic>AZINES</topic><topic>AZOLES</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and medical sciences</topic><topic>BIOLOGICAL EFFECTS</topic><topic>BLOOD VESSELS</topic><topic>BODY</topic><topic>CARDIOVASCULAR SYSTEM</topic><topic>CATTLE</topic><topic>CELL DIVISION</topic><topic>Cell growth</topic><topic>Cell physiology</topic><topic>Cultured cells</topic><topic>DNA</topic><topic>DNA - biosynthesis</topic><topic>DOMESTIC ANIMALS</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>DRUGS</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>Humans</topic><topic>HYDROXY COMPOUNDS</topic><topic>IN VITRO</topic><topic>INDOLES</topic><topic>LABELLED COMPOUNDS</topic><topic>MAMMALS</topic><topic>MITOGENS</topic><topic>MITOSIS</topic><topic>Molecular and cellular biology</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - physiology</topic><topic>MUSCLES</topic><topic>NEUROREGULATORS</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>ORGANS</topic><topic>Platelet-Derived Growth Factor - pharmacology</topic><topic>Platelets</topic><topic>PYRIMIDINES</topic><topic>PYRROLES</topic><topic>RADIOPROTECTIVE SUBSTANCES</topic><topic>Receptors</topic><topic>Receptors, Serotonin - drug effects</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>RIBOSIDES</topic><topic>RUMINANTS</topic><topic>SEROTONIN</topic><topic>Serotonin - pharmacology</topic><topic>Serotonin antagonists</topic><topic>Serotonin Antagonists - pharmacology</topic><topic>Smooth muscle</topic><topic>Smooth muscle myocytes</topic><topic>SYMPATHOMIMETICS</topic><topic>THYMIDINE</topic><topic>Thymidine - metabolism</topic><topic>TRITIUM COMPOUNDS</topic><topic>TRYPTAMINES</topic><topic>Ungulates</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nemecek, Georgina M.</creatorcontrib><creatorcontrib>Coughlin, Shaun R.</creatorcontrib><creatorcontrib>Handley, Dean A.</creatorcontrib><creatorcontrib>Moskowitz, Michael A.</creatorcontrib><creatorcontrib>Sandoz Research Institute, East Hanover, NJ</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nemecek, Georgina M.</au><au>Coughlin, Shaun R.</au><au>Handley, Dean A.</au><au>Moskowitz, Michael A.</au><aucorp>Sandoz Research Institute, East Hanover, NJ</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulation of Aortic Smooth Muscle Cell Mitogenesis by Serotonin</atitle><jtitle>Proc. Natl. Acad. Sci. U.S.A.; (United States)</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1986-02-01</date><risdate>1986</risdate><volume>83</volume><issue>3</issue><spage>674</spage><epage>678</epage><pages>674-678</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Bovine aortic smooth muscle cells in vitro responded to 1 nM to 10 μ M serotonin with increased incorporation of [3H]thymidine into DNA. The mitogenic effect of serotonin was half-maximal at 80 nM and maximal above 1 μ M. At a concentration of 1 μ M, serotonin stimulated smooth muscle cell mitogenesis to the same extent as human platelet-derived growth factor (PDGF) at 12 ng/ml. Tryptamine was ≈ 1/10th as potent as serotonin as a mitogen for smooth muscle cells. Other indoles that are structurally related to serotonin (D-and L-tryptophan, 5-hydroxy-L-tryptophan, N-acetyl-5-hydroxytryptamine, melatonin, 5-hydroxyindoleacetic acid, and 5-hydroxytryptophol) and quipazine were inactive. The stimulatory effect of serotonin on smooth muscle cell DNA synthesis required prolonged (20-24 hr) exposure to the agonist and was attenuated in the presence of serotonin D receptor antagonists. When smooth muscle cells were incubated with submaximal concentrations of serotonin and PDGF, synergistic rather than additive mitogenic responses were observed. These data indicate that serotonin has a significant mitogenic effect on smooth muscle cells in vitro, which appears to be mediated by specific plasma membrane receptors.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>3456163</pmid><doi>10.1073/pnas.83.3.674</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0027-8424 |
| ispartof | Proc. Natl. Acad. Sci. U.S.A.; (United States), 1986-02, Vol.83 (3), p.674-678 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_8593208 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 550301 - Cytology- Tracer Techniques AMINES ANIMALS AORTA Aorta - physiology AROMATICS ARTERIES AUTONOMIC NERVOUS SYSTEM AGENTS AZAARENES AZINES AZOLES BASIC BIOLOGICAL SCIENCES Biological and medical sciences BIOLOGICAL EFFECTS BLOOD VESSELS BODY CARDIOVASCULAR SYSTEM CATTLE CELL DIVISION Cell growth Cell physiology Cultured cells DNA DNA - biosynthesis DOMESTIC ANIMALS DOSE-RESPONSE RELATIONSHIPS DRUGS Fundamental and applied biological sciences. Psychology HETEROCYCLIC COMPOUNDS Humans HYDROXY COMPOUNDS IN VITRO INDOLES LABELLED COMPOUNDS MAMMALS MITOGENS MITOSIS Molecular and cellular biology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology MUSCLES NEUROREGULATORS NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS ORGANS Platelet-Derived Growth Factor - pharmacology Platelets PYRIMIDINES PYRROLES RADIOPROTECTIVE SUBSTANCES Receptors Receptors, Serotonin - drug effects Responses to growth factors, tumor promotors, other factors RIBOSIDES RUMINANTS SEROTONIN Serotonin - pharmacology Serotonin antagonists Serotonin Antagonists - pharmacology Smooth muscle Smooth muscle myocytes SYMPATHOMIMETICS THYMIDINE Thymidine - metabolism TRITIUM COMPOUNDS TRYPTAMINES Ungulates VERTEBRATES |
| title | Stimulation of Aortic Smooth Muscle Cell Mitogenesis by Serotonin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T20%3A04%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Stimulation%20of%20Aortic%20Smooth%20Muscle%20Cell%20Mitogenesis%20by%20Serotonin&rft.jtitle=Proc.%20Natl.%20Acad.%20Sci.%20U.S.A.;%20(United%20States)&rft.au=Nemecek,%20Georgina%20M.&rft.aucorp=Sandoz%20Research%20Institute,%20East%20Hanover,%20NJ&rft.date=1986-02-01&rft.volume=83&rft.issue=3&rft.spage=674&rft.epage=678&rft.pages=674-678&rft.issn=0027-8424&rft.eissn=1091-6490&rft.coden=PNASA6&rft_id=info:doi/10.1073/pnas.83.3.674&rft_dat=%3Cjstor_pasca%3E27403%3C/jstor_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76692755&rft_id=info:pmid/3456163&rft_jstor_id=27403&rfr_iscdi=true |