7-Deazaadenines Bearing Polar Substituents:  Structure−Activity Relationships of New A1 and A3 Adenosine Receptor Antagonists

A series of 28 new pyrrolo[2,3-d]pyrimidine-4-amines, pyrimido[4,5-b]indole-4-amines, and tetrahydropyrimido[4,5-b]indole-4-amines was synthesized and their adenosine receptor affinity determined in radioligand binding assays at rat A1 and A2A adenosine receptors (ARs). Selected compounds were addit...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-11, Vol.43 (24), p.4636-4646
Hauptverfasser:	Hess, Sonja, Müller, Christa E, Frobenius, Wolfram, Reith, Ulrike, Klotz, Karl-Norbert, Eger, Kurt
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments
Online-Zugang:	Volltext
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