Prostaglandin Mediation of Hemodynamic Responses to Pulmonary Microembolism in Rabbits: Effects of Ibuprofen and Meclofenamate
The effect of the cyclooxygenase inhibitors ibuprofen and meclofenamate were studied to assess the role of prostaglandin release in mediating the hemodynamic response to acute pulmonary microembolism in awake rabbits. In Group I (n = 10), a control group receiving only saline infusion, there was no...
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| Veröffentlicht in: | Experimental lung research 1987, Vol.12 (4), p.331-345 |
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| creator | Konstam, Marvin A. Hill, Nicholas S. Bonin, John D. Isner, Jeffrey M. |
| description | The effect of the cyclooxygenase inhibitors ibuprofen and meclofenamate were studied to assess the role of prostaglandin release in mediating the hemodynamic response to acute pulmonary microembolism in awake rabbits. In Group I (n = 10), a control group receiving only saline infusion, there was no change in pulmonary artery pressure, thermodilution cardiac output, or pulmonary vascular resistance. Group II (n = 12) received sequential intravenous doses of polyacrylamide microspheres averaging 34 μ in diameter, and demonstrated a progressive decrease in cardiac output and stroke volume and increases in pulmonary artery pressure and pulmonary vascular resistance. Pretreatment with either ibuprofen (Group III; n = 10) or meclofenamate (Group IV; n = 9) resulted in no change in resting hemodynamics and only minimally altered the effect of microembolism on pulmonary artery pressure. However, both ibuprofen and meclofenamate abolished the microembolism-induced decrease in cardiac output and stroke volume and blunted the increases in pulmonary artery pressure and pulmonary vascular resistance. The hemodynamic consequences of pulmonary microembolism in awake rabbits, particularly the decrease in cardiac output, are partly mediated by prostaglandin release, which alters pulmonary vascular tone and/or myocardial function. |
| doi_str_mv | 10.3109/01902148709062844 |
| format | Article |
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In Group I (n = 10), a control group receiving only saline infusion, there was no change in pulmonary artery pressure, thermodilution cardiac output, or pulmonary vascular resistance. Group II (n = 12) received sequential intravenous doses of polyacrylamide microspheres averaging 34 μ in diameter, and demonstrated a progressive decrease in cardiac output and stroke volume and increases in pulmonary artery pressure and pulmonary vascular resistance. Pretreatment with either ibuprofen (Group III; n = 10) or meclofenamate (Group IV; n = 9) resulted in no change in resting hemodynamics and only minimally altered the effect of microembolism on pulmonary artery pressure. However, both ibuprofen and meclofenamate abolished the microembolism-induced decrease in cardiac output and stroke volume and blunted the increases in pulmonary artery pressure and pulmonary vascular resistance. The hemodynamic consequences of pulmonary microembolism in awake rabbits, particularly the decrease in cardiac output, are partly mediated by prostaglandin release, which alters pulmonary vascular tone and/or myocardial function.</description><identifier>ISSN: 0190-2148</identifier><identifier>EISSN: 1521-0499</identifier><identifier>DOI: 10.3109/01902148709062844</identifier><identifier>PMID: 3582284</identifier><identifier>CODEN: EXLRDA</identifier><language>eng</language><publisher>Philadelphia, PA: Informa UK Ltd</publisher><subject>Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiac Output - drug effects ; Cardiology. Vascular system ; Chronic cor pulmonale ; Disease Models, Animal ; Heart ; Hemodynamics ; Ibuprofen - pharmacology ; Meclofenamic Acid - pharmacology ; Medical sciences ; ortho-Aminobenzoates - pharmacology ; Pneumology ; Prostaglandins - physiology ; Pulmonary Circulation - drug effects ; Pulmonary Embolism - physiopathology ; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases ; Rabbits ; Vascular Resistance - drug effects</subject><ispartof>Experimental lung research, 1987, Vol.12 (4), p.331-345</ispartof><rights>1987 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1987</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-e94e183ff211c9bf99e324ea25072eb2b695a5152a1cbb1f09839a67d90dc5a53</citedby><cites>FETCH-LOGICAL-c430t-e94e183ff211c9bf99e324ea25072eb2b695a5152a1cbb1f09839a67d90dc5a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/01902148709062844$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/01902148709062844$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8280731$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3582284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Konstam, Marvin A.</creatorcontrib><creatorcontrib>Hill, Nicholas S.</creatorcontrib><creatorcontrib>Bonin, John D.</creatorcontrib><creatorcontrib>Isner, Jeffrey M.</creatorcontrib><title>Prostaglandin Mediation of Hemodynamic Responses to Pulmonary Microembolism in Rabbits: Effects of Ibuprofen and Meclofenamate</title><title>Experimental lung research</title><addtitle>Exp Lung Res</addtitle><description>The effect of the cyclooxygenase inhibitors ibuprofen and meclofenamate were studied to assess the role of prostaglandin release in mediating the hemodynamic response to acute pulmonary microembolism in awake rabbits. In Group I (n = 10), a control group receiving only saline infusion, there was no change in pulmonary artery pressure, thermodilution cardiac output, or pulmonary vascular resistance. Group II (n = 12) received sequential intravenous doses of polyacrylamide microspheres averaging 34 μ in diameter, and demonstrated a progressive decrease in cardiac output and stroke volume and increases in pulmonary artery pressure and pulmonary vascular resistance. Pretreatment with either ibuprofen (Group III; n = 10) or meclofenamate (Group IV; n = 9) resulted in no change in resting hemodynamics and only minimally altered the effect of microembolism on pulmonary artery pressure. However, both ibuprofen and meclofenamate abolished the microembolism-induced decrease in cardiac output and stroke volume and blunted the increases in pulmonary artery pressure and pulmonary vascular resistance. The hemodynamic consequences of pulmonary microembolism in awake rabbits, particularly the decrease in cardiac output, are partly mediated by prostaglandin release, which alters pulmonary vascular tone and/or myocardial function.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Chronic cor pulmonale</subject><subject>Disease Models, Animal</subject><subject>Heart</subject><subject>Hemodynamics</subject><subject>Ibuprofen - pharmacology</subject><subject>Meclofenamic Acid - pharmacology</subject><subject>Medical sciences</subject><subject>ortho-Aminobenzoates - pharmacology</subject><subject>Pneumology</subject><subject>Prostaglandins - physiology</subject><subject>Pulmonary Circulation - drug effects</subject><subject>Pulmonary Embolism - physiopathology</subject><subject>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</subject><subject>Rabbits</subject><subject>Vascular Resistance - drug effects</subject><issn>0190-2148</issn><issn>1521-0499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1rFTEUxYMo9bX6B7gQshB3o_mYeTNRN1JaW2ixFF0PdzI3NiUfzySDvI1_u3m8Z0GErkK4v3PuPYeQV5y9k5yp94wrJng79EyxtRja9glZ8U7whrVKPSWr3bzZAc_Jcc73jDHRDesjciS7QVR-RX7fpJgL_HAQZhvoNc4Wio2BRkMv0Md5G8BbTW8xb2LImGmJ9GZxPgZIW3ptdYrop-hs9rQa3MI02ZI_0DNjUJe887mclk2KBgOtS-oK7XYf8FDwBXlmwGV8eXhPyPfzs2-nF83V1y-Xp5-vGt1KVhpULfJBGiM412oySqEULYLoWC9wEtNaddDV5MD1NHHD1CAVrPtZsVnXiTwhb_e-9ZCfC-Yyeps1uhob45LHvu9kL9hQQb4Ha66cE5pxk6yvUUfOxl3n43-dV83rg_kyeZwfFIeS6_zNYQ5ZgzMJgrb5ARvEwHrJK_Zpj9lgYvLwKyY3jwW2Lqa_GvnYFR__kd8huHKnIeF4H5cUar2PZPgDxMyv8g</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>Konstam, Marvin A.</creator><creator>Hill, Nicholas S.</creator><creator>Bonin, John D.</creator><creator>Isner, Jeffrey M.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>Prostaglandin Mediation of Hemodynamic Responses to Pulmonary Microembolism in Rabbits: Effects of Ibuprofen and Meclofenamate</title><author>Konstam, Marvin A. ; Hill, Nicholas S. ; Bonin, John D. ; Isner, Jeffrey M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-e94e183ff211c9bf99e324ea25072eb2b695a5152a1cbb1f09839a67d90dc5a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Chronic cor pulmonale</topic><topic>Disease Models, Animal</topic><topic>Heart</topic><topic>Hemodynamics</topic><topic>Ibuprofen - pharmacology</topic><topic>Meclofenamic Acid - pharmacology</topic><topic>Medical sciences</topic><topic>ortho-Aminobenzoates - pharmacology</topic><topic>Pneumology</topic><topic>Prostaglandins - physiology</topic><topic>Pulmonary Circulation - drug effects</topic><topic>Pulmonary Embolism - physiopathology</topic><topic>Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases</topic><topic>Rabbits</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Konstam, Marvin A.</creatorcontrib><creatorcontrib>Hill, Nicholas S.</creatorcontrib><creatorcontrib>Bonin, John D.</creatorcontrib><creatorcontrib>Isner, Jeffrey M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental lung research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Konstam, Marvin A.</au><au>Hill, Nicholas S.</au><au>Bonin, John D.</au><au>Isner, Jeffrey M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostaglandin Mediation of Hemodynamic Responses to Pulmonary Microembolism in Rabbits: Effects of Ibuprofen and Meclofenamate</atitle><jtitle>Experimental lung research</jtitle><addtitle>Exp Lung Res</addtitle><date>1987</date><risdate>1987</risdate><volume>12</volume><issue>4</issue><spage>331</spage><epage>345</epage><pages>331-345</pages><issn>0190-2148</issn><eissn>1521-0499</eissn><coden>EXLRDA</coden><abstract>The effect of the cyclooxygenase inhibitors ibuprofen and meclofenamate were studied to assess the role of prostaglandin release in mediating the hemodynamic response to acute pulmonary microembolism in awake rabbits. In Group I (n = 10), a control group receiving only saline infusion, there was no change in pulmonary artery pressure, thermodilution cardiac output, or pulmonary vascular resistance. Group II (n = 12) received sequential intravenous doses of polyacrylamide microspheres averaging 34 μ in diameter, and demonstrated a progressive decrease in cardiac output and stroke volume and increases in pulmonary artery pressure and pulmonary vascular resistance. Pretreatment with either ibuprofen (Group III; n = 10) or meclofenamate (Group IV; n = 9) resulted in no change in resting hemodynamics and only minimally altered the effect of microembolism on pulmonary artery pressure. However, both ibuprofen and meclofenamate abolished the microembolism-induced decrease in cardiac output and stroke volume and blunted the increases in pulmonary artery pressure and pulmonary vascular resistance. The hemodynamic consequences of pulmonary microembolism in awake rabbits, particularly the decrease in cardiac output, are partly mediated by prostaglandin release, which alters pulmonary vascular tone and/or myocardial function.</abstract><cop>Philadelphia, PA</cop><pub>Informa UK Ltd</pub><pmid>3582284</pmid><doi>10.3109/01902148709062844</doi><tpages>15</tpages></addata></record> |
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| ispartof | Experimental lung research, 1987, Vol.12 (4), p.331-345 |
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| subjects | Animals Biological and medical sciences Blood Pressure - drug effects Cardiac Output - drug effects Cardiology. Vascular system Chronic cor pulmonale Disease Models, Animal Heart Hemodynamics Ibuprofen - pharmacology Meclofenamic Acid - pharmacology Medical sciences ortho-Aminobenzoates - pharmacology Pneumology Prostaglandins - physiology Pulmonary Circulation - drug effects Pulmonary Embolism - physiopathology Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Rabbits Vascular Resistance - drug effects |
| title | Prostaglandin Mediation of Hemodynamic Responses to Pulmonary Microembolism in Rabbits: Effects of Ibuprofen and Meclofenamate |
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