Alterations in the lipids and prostaglandins in mouse spleen following and ingestion of menhaden oil
Two groups of male mice were fed for 2 weeks with a semisynthetic diet supplemented with either 10% hydrogenated coconut oil or 10% menhaden oil. The spleen from animals fed with menhaden oil contained significantly higher amounts of polyunsaturated n-3 fatty acids. The n-3 fatty acids reciprocally...
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| Veröffentlicht in: | Annals of nutrition and metabolism 1986, Vol.30 (6), p.357-364 |
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| container_title | Annals of nutrition and metabolism |
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| creator | Lokesh, Belur R. Hsieh, Hui L. Kinsella, John E. |
| description | Two groups of male mice were fed for 2 weeks with a semisynthetic diet supplemented with either 10% hydrogenated coconut oil or 10% menhaden oil. The spleen from animals fed with menhaden oil contained significantly higher amounts of polyunsaturated n-3 fatty acids. The n-3 fatty acids reciprocally replaced arachidonic acid in the phospholipids. The synthesis of 6-keto prostaglandin F1α and prostaglandin E₂ by spleen tissues were significantly depressed (70-80%) in mice consuming menhaden oil. These studies indicated that n-3 fatty acids can effectively displace arachidonic acid from spleen lipids and thereby affect the synthesis of prostaglandins. The implications of these observations are discussed. |
| doi_str_mv | 10.1159/000177215 |
| format | Article |
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The spleen from animals fed with menhaden oil contained significantly higher amounts of polyunsaturated n-3 fatty acids. The n-3 fatty acids reciprocally replaced arachidonic acid in the phospholipids. The synthesis of 6-keto prostaglandin F1α and prostaglandin E₂ by spleen tissues were significantly depressed (70-80%) in mice consuming menhaden oil. These studies indicated that n-3 fatty acids can effectively displace arachidonic acid from spleen lipids and thereby affect the synthesis of prostaglandins. The implications of these observations are discussed.</description><identifier>ISSN: 0250-6807</identifier><identifier>EISSN: 1421-9697</identifier><identifier>DOI: 10.1159/000177215</identifier><identifier>PMID: 3789656</identifier><language>eng</language><publisher>Basel, Switzerland: S. 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Karger AG, Basel</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-1298cb0bf8f8409fa6c0e436cddc7c031ed61de5df43b9ad6193e62c0a18eaad3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/45100131$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/45100131$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,4009,27902,27903,27904,57996,58229</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8255125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3789656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lokesh, Belur R.</creatorcontrib><creatorcontrib>Hsieh, Hui L.</creatorcontrib><creatorcontrib>Kinsella, John E.</creatorcontrib><title>Alterations in the lipids and prostaglandins in mouse spleen following and ingestion of menhaden oil</title><title>Annals of nutrition and metabolism</title><addtitle>Ann Nutr Metab</addtitle><description>Two groups of male mice were fed for 2 weeks with a semisynthetic diet supplemented with either 10% hydrogenated coconut oil or 10% menhaden oil. The spleen from animals fed with menhaden oil contained significantly higher amounts of polyunsaturated n-3 fatty acids. The n-3 fatty acids reciprocally replaced arachidonic acid in the phospholipids. The synthesis of 6-keto prostaglandin F1α and prostaglandin E₂ by spleen tissues were significantly depressed (70-80%) in mice consuming menhaden oil. These studies indicated that n-3 fatty acids can effectively displace arachidonic acid from spleen lipids and thereby affect the synthesis of prostaglandins. The implications of these observations are discussed.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - metabolism</subject><subject>diet</subject><subject>Dietary Fats, Unsaturated - pharmacology</subject><subject>Fatty Acids - metabolism</subject><subject>Fish Oils - pharmacology</subject><subject>Food toxicology</subject><subject>lipids</subject><subject>Male</subject><subject>Medical sciences</subject><subject>menhaden oil</subject><subject>Mice</subject><subject>Original Paper</subject><subject>Original Papers</subject><subject>Phospholipids - metabolism</subject><subject>prostaglandins</subject><subject>Prostaglandins - biosynthesis</subject><subject>Proteins - metabolism</subject><subject>spleen</subject><subject>Spleen - metabolism</subject><subject>Toxicology</subject><issn>0250-6807</issn><issn>1421-9697</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtvEzEUhS0EKqGwYA_CEhUSiwG_x15GFQWkAgvoeuT4kbp4HrUnQvx7bpiQbFhdW-fTuecehJ5T8o5Sad4TQmjbMiofoBUVjDZGmfYhWhEmSaM0aR-jJ7XeAcW0kGfojLfaKKlWyK_zHIqd0zhUnAY83wac05R8xXbweCpjne02wzstQD_uasB1yiEMOI45j7_SsP0Lwwx174THiPsw3FoPzJjyU_Qo2lzDs8M8RzdXH35cfmquv338fLm-bpwgYm4oM9ptyCbqqAUx0SpHguDKee9aRzgNXlEfpI-Cb4yFj-FBMUcs1cFaz8_Rm8UXYt_vIEvXp-pChvgBYndQEaHaGADfLqCD-2oJsZtK6m353VHS7Rvtjo0C-_Jgutv0wR_JQ4WgXxx0W53NsdjBpXrENJOSsr3NiwX7acs2lNPCf1te_1def_2yEN3k4ynLXZ3HEyQkhbicgv5q0aMdO7stkOPmO9zMCRVKc6b5H7OKpns</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Lokesh, Belur R.</creator><creator>Hsieh, Hui L.</creator><creator>Kinsella, John E.</creator><general>S. 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The spleen from animals fed with menhaden oil contained significantly higher amounts of polyunsaturated n-3 fatty acids. The n-3 fatty acids reciprocally replaced arachidonic acid in the phospholipids. The synthesis of 6-keto prostaglandin F1α and prostaglandin E₂ by spleen tissues were significantly depressed (70-80%) in mice consuming menhaden oil. These studies indicated that n-3 fatty acids can effectively displace arachidonic acid from spleen lipids and thereby affect the synthesis of prostaglandins. The implications of these observations are discussed.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger</pub><pmid>3789656</pmid><doi>10.1159/000177215</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-6807 |
| ispartof | Annals of nutrition and metabolism, 1986, Vol.30 (6), p.357-364 |
| issn | 0250-6807 1421-9697 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Animals Biological and medical sciences Cholesterol - metabolism diet Dietary Fats, Unsaturated - pharmacology Fatty Acids - metabolism Fish Oils - pharmacology Food toxicology lipids Male Medical sciences menhaden oil Mice Original Paper Original Papers Phospholipids - metabolism prostaglandins Prostaglandins - biosynthesis Proteins - metabolism spleen Spleen - metabolism Toxicology |
| title | Alterations in the lipids and prostaglandins in mouse spleen following and ingestion of menhaden oil |
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