INHIBITORY EFFECTS OF POLYPRENOIC ACID (E-5166) ON N-2-FLUORENYL-ACETAMIDE-INITIATED HEPATOCARCINOGENESIS IN RATS
The effects of the newly synthesized polyprenoic acid, 3, 7, 11, 15-tetramethyl-2, 4, 6, -10, 14-hexadecapentaenoic acid (E-5166) on N-2-fluorenylacetamide (FAA)-initiated hepatocarcinogenesis were examined in 6 groups of male ACI rats. The numbers of altered hepatocellular foci in rats of group 1 g...
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| Veröffentlicht in: | Japanese Journal of Cancer Research GANN 1986, Vol.77(4), pp.351-355 |
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| container_title | Japanese Journal of Cancer Research GANN |
| container_volume | 77 |
| creator | SHIMA, Hiroto KUNIYASU, Tokuro SUGIE, Shigeyuki TANAKA, Takuji MORI, Hideki TAKAHASHI, Masayoshi MUTO, Yasutoshi |
| description | The effects of the newly synthesized polyprenoic acid, 3, 7, 11, 15-tetramethyl-2, 4, 6, -10, 14-hexadecapentaenoic acid (E-5166) on N-2-fluorenylacetamide (FAA)-initiated hepatocarcinogenesis were examined in 6 groups of male ACI rats. The numbers of altered hepatocellular foci in rats of group 1 given a basal diet containing 0.02% FAA for 13 weeks and in rats of group 2 which received E-5166 by gavage (40mg/kg, 3 times/week) at the same time as receiving the FAA diet were almost the same, indicating that E-5166 had no effect at the stage of carcinogen exposure. However, the number of foci in group 4, in which rats were given the basal diet and E-5166 after the termination of the carcinogen exposure, and were sacrificed 16 weeks later, was significantly smaller than that in group 3 maintained on the basal diet alone (P |
| doi_str_mv | 10.20772/cancersci1985.77.4_351 |
| format | Article |
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The numbers of altered hepatocellular foci in rats of group 1 given a basal diet containing 0.02% FAA for 13 weeks and in rats of group 2 which received E-5166 by gavage (40mg/kg, 3 times/week) at the same time as receiving the FAA diet were almost the same, indicating that E-5166 had no effect at the stage of carcinogen exposure. However, the number of foci in group 4, in which rats were given the basal diet and E-5166 after the termination of the carcinogen exposure, and were sacrificed 16 weeks later, was significantly smaller than that in group 3 maintained on the basal diet alone (P<0.05). The result suggests some anticarcinogenic activity of E-5166, possibly involving the phenotypic expression of the preneoplastic foci. Furthermore, the number of altered foci in rats of group 6 (given the liver-tumor promoter phenobarbital with E-5166 for 16 weeks after the administration of carcinogen) was also significantly smaller than that in rats of group 5, which received the promoter (P<0.05). The incidence of neoplastic nodules of the liver in group 6 at the end of the experiment was also lower than in group 5 (P<0.0014). These results suggest an antipromoting effect of the polyprenoic acid E-5166 on rat chemical hepatocarcinogenesis.</description><identifier>ISSN: 0910-5050</identifier><identifier>EISSN: 1876-4673</identifier><identifier>DOI: 10.20772/cancersci1985.77.4_351</identifier><identifier>CODEN: GANNA2</identifier><language>eng</language><publisher>Tokyo: The Japanese Cancer Association</publisher><subject>Antipromoting effect ; Applied sciences ; Biological and medical sciences ; Carcinogenesis, carcinogens and anticarcinogens ; Chemical agents ; Exact sciences and technology ; Hepatocarcinogenesis ; Medical sciences ; N-2-Fluorenylacetamide ; Other techniques and industries ; Phenobarbital ; Polyprenoic acid ; Tumors</subject><ispartof>Japanese Journal of Cancer Research GANN, 1986, Vol.77(4), pp.351-355</ispartof><rights>The Japanese Cancer Association</rights><rights>1987 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8132372$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8184285$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIMA, Hiroto</creatorcontrib><creatorcontrib>KUNIYASU, Tokuro</creatorcontrib><creatorcontrib>SUGIE, Shigeyuki</creatorcontrib><creatorcontrib>TANAKA, Takuji</creatorcontrib><creatorcontrib>MORI, Hideki</creatorcontrib><creatorcontrib>TAKAHASHI, Masayoshi</creatorcontrib><creatorcontrib>MUTO, Yasutoshi</creatorcontrib><title>INHIBITORY EFFECTS OF POLYPRENOIC ACID (E-5166) ON N-2-FLUORENYL-ACETAMIDE-INITIATED HEPATOCARCINOGENESIS IN RATS</title><title>Japanese Journal of Cancer Research GANN</title><addtitle>Japanese Journal of Cancer Research GANN</addtitle><description>The effects of the newly synthesized polyprenoic acid, 3, 7, 11, 15-tetramethyl-2, 4, 6, -10, 14-hexadecapentaenoic acid (E-5166) on N-2-fluorenylacetamide (FAA)-initiated hepatocarcinogenesis were examined in 6 groups of male ACI rats. The numbers of altered hepatocellular foci in rats of group 1 given a basal diet containing 0.02% FAA for 13 weeks and in rats of group 2 which received E-5166 by gavage (40mg/kg, 3 times/week) at the same time as receiving the FAA diet were almost the same, indicating that E-5166 had no effect at the stage of carcinogen exposure. However, the number of foci in group 4, in which rats were given the basal diet and E-5166 after the termination of the carcinogen exposure, and were sacrificed 16 weeks later, was significantly smaller than that in group 3 maintained on the basal diet alone (P<0.05). The result suggests some anticarcinogenic activity of E-5166, possibly involving the phenotypic expression of the preneoplastic foci. Furthermore, the number of altered foci in rats of group 6 (given the liver-tumor promoter phenobarbital with E-5166 for 16 weeks after the administration of carcinogen) was also significantly smaller than that in rats of group 5, which received the promoter (P<0.05). The incidence of neoplastic nodules of the liver in group 6 at the end of the experiment was also lower than in group 5 (P<0.0014). These results suggest an antipromoting effect of the polyprenoic acid E-5166 on rat chemical hepatocarcinogenesis.</description><subject>Antipromoting effect</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Carcinogenesis, carcinogens and anticarcinogens</subject><subject>Chemical agents</subject><subject>Exact sciences and technology</subject><subject>Hepatocarcinogenesis</subject><subject>Medical sciences</subject><subject>N-2-Fluorenylacetamide</subject><subject>Other techniques and industries</subject><subject>Phenobarbital</subject><subject>Polyprenoic acid</subject><subject>Tumors</subject><issn>0910-5050</issn><issn>1876-4673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><recordid>eNqFkT1PwzAYhC0EEqXwG_DAAIOLP2NnDK7TWgpxlaRDp8ikDrQqVUm68O-JVARiYrl3uEevTncA3BI8oVhK-tj4fRO6vtmQWImJlBNeM0HOwIgoGSEeSXYORjgmGAks8CW46vstxkTiiI7Ah83n9slWrlhBk6ZGVyV0KVy4bLUoTO6shom2U3hvkCBR9ABdDnNEUZot3eCvMpRoUyXPdmqQzW1lk8pM4dwsksrppNA2dzOTm9KW0OawSKryGly0fteHm-87BsvUVHqOMjezOsnQlil1HHILH4SMlZRKtUNYTFsm1jEW_kXSlgYfxZSFhgsvaBPEWrU-rGPKRcvbSHI2BnenvwffN37XdkNNm74-dJt3333WiihOlfgfY5RJOmD2hG37o38NP77vjptmF-o_I9RS1vwkwxK_zJvv6rBnX6egfDQ</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>SHIMA, Hiroto</creator><creator>KUNIYASU, Tokuro</creator><creator>SUGIE, Shigeyuki</creator><creator>TANAKA, Takuji</creator><creator>MORI, Hideki</creator><creator>TAKAHASHI, Masayoshi</creator><creator>MUTO, Yasutoshi</creator><general>The Japanese Cancer Association</general><general>Japanese Cancer Association</general><scope>IQODW</scope></search><sort><creationdate>1986</creationdate><title>INHIBITORY EFFECTS OF POLYPRENOIC ACID (E-5166) ON N-2-FLUORENYL-ACETAMIDE-INITIATED HEPATOCARCINOGENESIS IN RATS</title><author>SHIMA, Hiroto ; KUNIYASU, Tokuro ; SUGIE, Shigeyuki ; TANAKA, Takuji ; MORI, Hideki ; TAKAHASHI, Masayoshi ; MUTO, Yasutoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j388t-465ae57987788f70602f35d905ab72f2ea6923ec45a52ce5d8faed9245f4f6743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Antipromoting effect</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Carcinogenesis, carcinogens and anticarcinogens</topic><topic>Chemical agents</topic><topic>Exact sciences and technology</topic><topic>Hepatocarcinogenesis</topic><topic>Medical sciences</topic><topic>N-2-Fluorenylacetamide</topic><topic>Other techniques and industries</topic><topic>Phenobarbital</topic><topic>Polyprenoic acid</topic><topic>Tumors</topic><toplevel>online_resources</toplevel><creatorcontrib>SHIMA, Hiroto</creatorcontrib><creatorcontrib>KUNIYASU, Tokuro</creatorcontrib><creatorcontrib>SUGIE, Shigeyuki</creatorcontrib><creatorcontrib>TANAKA, Takuji</creatorcontrib><creatorcontrib>MORI, Hideki</creatorcontrib><creatorcontrib>TAKAHASHI, Masayoshi</creatorcontrib><creatorcontrib>MUTO, Yasutoshi</creatorcontrib><collection>Pascal-Francis</collection><jtitle>Japanese Journal of Cancer Research GANN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIMA, Hiroto</au><au>KUNIYASU, Tokuro</au><au>SUGIE, Shigeyuki</au><au>TANAKA, Takuji</au><au>MORI, Hideki</au><au>TAKAHASHI, Masayoshi</au><au>MUTO, Yasutoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>INHIBITORY EFFECTS OF POLYPRENOIC ACID (E-5166) ON N-2-FLUORENYL-ACETAMIDE-INITIATED HEPATOCARCINOGENESIS IN RATS</atitle><jtitle>Japanese Journal of Cancer Research GANN</jtitle><addtitle>Japanese Journal of Cancer Research GANN</addtitle><date>1986</date><risdate>1986</risdate><volume>77</volume><issue>4</issue><spage>351</spage><epage>355</epage><pages>351-355</pages><issn>0910-5050</issn><eissn>1876-4673</eissn><coden>GANNA2</coden><abstract>The effects of the newly synthesized polyprenoic acid, 3, 7, 11, 15-tetramethyl-2, 4, 6, -10, 14-hexadecapentaenoic acid (E-5166) on N-2-fluorenylacetamide (FAA)-initiated hepatocarcinogenesis were examined in 6 groups of male ACI rats. The numbers of altered hepatocellular foci in rats of group 1 given a basal diet containing 0.02% FAA for 13 weeks and in rats of group 2 which received E-5166 by gavage (40mg/kg, 3 times/week) at the same time as receiving the FAA diet were almost the same, indicating that E-5166 had no effect at the stage of carcinogen exposure. However, the number of foci in group 4, in which rats were given the basal diet and E-5166 after the termination of the carcinogen exposure, and were sacrificed 16 weeks later, was significantly smaller than that in group 3 maintained on the basal diet alone (P<0.05). The result suggests some anticarcinogenic activity of E-5166, possibly involving the phenotypic expression of the preneoplastic foci. Furthermore, the number of altered foci in rats of group 6 (given the liver-tumor promoter phenobarbital with E-5166 for 16 weeks after the administration of carcinogen) was also significantly smaller than that in rats of group 5, which received the promoter (P<0.05). The incidence of neoplastic nodules of the liver in group 6 at the end of the experiment was also lower than in group 5 (P<0.0014). These results suggest an antipromoting effect of the polyprenoic acid E-5166 on rat chemical hepatocarcinogenesis.</abstract><cop>Tokyo</cop><pub>The Japanese Cancer Association</pub><doi>10.20772/cancersci1985.77.4_351</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0910-5050 |
| ispartof | Japanese Journal of Cancer Research GANN, 1986, Vol.77(4), pp.351-355 |
| issn | 0910-5050 1876-4673 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_8184285 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antipromoting effect Applied sciences Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Exact sciences and technology Hepatocarcinogenesis Medical sciences N-2-Fluorenylacetamide Other techniques and industries Phenobarbital Polyprenoic acid Tumors |
| title | INHIBITORY EFFECTS OF POLYPRENOIC ACID (E-5166) ON N-2-FLUORENYL-ACETAMIDE-INITIATED HEPATOCARCINOGENESIS IN RATS |
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