BRAIN WATER MEASURED BY MAGNETIC RESONANCE IMAGING: Correlation with Direct Estimation and Changes After Mannitol and Dexamethasone
Brain water content was measured in tissue samples taken at operation from 19 patients with intrinsic cerebral tumours imaged preoperatively by magnetic resonance. A high correlation (r = 0·94, p
Gespeichert in:
| Veröffentlicht in: | The Lancet (British edition) 1987-01, Vol.329 (8524), p.66-69 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 69 |
|---|---|
| container_issue | 8524 |
| container_start_page | 66 |
| container_title | The Lancet (British edition) |
| container_volume | 329 |
| creator | Bell, B.A. Kean, D.M. Macdonald, H.L. Barnett, G.H. Douglas, R.H.B. Smith, M.A. Mcghee, C.N.J. Miller, J.D. Tocher, J.L. Best, J.J.K. |
| description | Brain water content was measured in tissue samples taken at operation from 19 patients with intrinsic cerebral tumours imaged preoperatively by magnetic resonance. A high correlation (r = 0·94, p |
| doi_str_mv | 10.1016/S0140-6736(87)91908-8 |
| format | Article |
| fullrecord | <record><control><sourceid>elsevier_pasca</sourceid><recordid>TN_cdi_pascalfrancis_primary_8159191</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0140673687919088</els_id><sourcerecordid>S0140673687919088</sourcerecordid><originalsourceid>FETCH-LOGICAL-e153t-8dc7ceb05ff3b3c0df2049b5505cc1568e9485bab16e43143c62bfdfe3f3d343</originalsourceid><addsrcrecordid>eNo9kF1LwzAUhoMoOD9-gpALL_SimixJm3kjXVdnYetgm6hXIU1PXGS20hQ_rv3jdpt4deA9D4f3PAidUXJFCQ2vF4RyEoQRCy9kdDmgAyIDuYd6lEc8EDx62ke9f-QQHXn_SgjhIRE99DOcx1mOH-NlOsfTNF48zNMRHj7jaTzO02WW4Hm6mOVxnqQ467IsH9_gpG4aWOvW1RX-dO0Kj1wDpsWpb93bLtZViZOVrl7A49i20OCprirX1uvtagRf-g3alfZ1BSfowOq1h9O_eYyWd-kyuQ8ms3GWxJMAqGBtIEsTGSiIsJYVzJDS9gkfFEIQYQwVoYQBl6LQBQ2BM8qZCfuFLS0wy0rG2TE63519197otW10ZZxX703XuflWkopOHe2w2x0GXZUPB43yxkFloNw-qcraKUrUxrzamlcbrUpGamteSfYLpD91CA</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>BRAIN WATER MEASURED BY MAGNETIC RESONANCE IMAGING: Correlation with Direct Estimation and Changes After Mannitol and Dexamethasone</title><source>Elsevier ScienceDirect Journals</source><creator>Bell, B.A. ; Kean, D.M. ; Macdonald, H.L. ; Barnett, G.H. ; Douglas, R.H.B. ; Smith, M.A. ; Mcghee, C.N.J. ; Miller, J.D. ; Tocher, J.L. ; Best, J.J.K.</creator><creatorcontrib>Bell, B.A. ; Kean, D.M. ; Macdonald, H.L. ; Barnett, G.H. ; Douglas, R.H.B. ; Smith, M.A. ; Mcghee, C.N.J. ; Miller, J.D. ; Tocher, J.L. ; Best, J.J.K.</creatorcontrib><description>Brain water content was measured in tissue samples taken at operation from 19 patients with intrinsic cerebral tumours imaged preoperatively by magnetic resonance. A high correlation (r = 0·94, p<0·0001) between white matter water content and the longitudinal relaxation time (T
1) enabled water content to be estimated from T
1 to within 4%. 11 patients received dexamethasone and improved clinically but their T
1, and thus brain water content, was unchanged an average of 6 days later. Intravenous infusion of 20% mannitol in 11 patients significantly reduced T
1 in oedematous white matter and tumour within 15 min of administration, and by 30 min the T
1 of oedematous white matter had fallen to a mean of 32·4 (SEM 7·1) ms, corresponding to a reduction in water content of 1·4 (0·3)%.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(87)91908-8</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Investigative techniques, diagnostic techniques (general aspects) ; Medical sciences ; Nervous system ; Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><ispartof>The Lancet (British edition), 1987-01, Vol.329 (8524), p.66-69</ispartof><rights>1987</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673687919088$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8159191$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Bell, B.A.</creatorcontrib><creatorcontrib>Kean, D.M.</creatorcontrib><creatorcontrib>Macdonald, H.L.</creatorcontrib><creatorcontrib>Barnett, G.H.</creatorcontrib><creatorcontrib>Douglas, R.H.B.</creatorcontrib><creatorcontrib>Smith, M.A.</creatorcontrib><creatorcontrib>Mcghee, C.N.J.</creatorcontrib><creatorcontrib>Miller, J.D.</creatorcontrib><creatorcontrib>Tocher, J.L.</creatorcontrib><creatorcontrib>Best, J.J.K.</creatorcontrib><title>BRAIN WATER MEASURED BY MAGNETIC RESONANCE IMAGING: Correlation with Direct Estimation and Changes After Mannitol and Dexamethasone</title><title>The Lancet (British edition)</title><description>Brain water content was measured in tissue samples taken at operation from 19 patients with intrinsic cerebral tumours imaged preoperatively by magnetic resonance. A high correlation (r = 0·94, p<0·0001) between white matter water content and the longitudinal relaxation time (T
1) enabled water content to be estimated from T
1 to within 4%. 11 patients received dexamethasone and improved clinically but their T
1, and thus brain water content, was unchanged an average of 6 days later. Intravenous infusion of 20% mannitol in 11 patients significantly reduced T
1 in oedematous white matter and tumour within 15 min of administration, and by 30 min the T
1 of oedematous white matter had fallen to a mean of 32·4 (SEM 7·1) ms, corresponding to a reduction in water content of 1·4 (0·3)%.</description><subject>Biological and medical sciences</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Nervous system</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><issn>0140-6736</issn><issn>1474-547X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNo9kF1LwzAUhoMoOD9-gpALL_SimixJm3kjXVdnYetgm6hXIU1PXGS20hQ_rv3jdpt4deA9D4f3PAidUXJFCQ2vF4RyEoQRCy9kdDmgAyIDuYd6lEc8EDx62ke9f-QQHXn_SgjhIRE99DOcx1mOH-NlOsfTNF48zNMRHj7jaTzO02WW4Hm6mOVxnqQ467IsH9_gpG4aWOvW1RX-dO0Kj1wDpsWpb93bLtZViZOVrl7A49i20OCprirX1uvtagRf-g3alfZ1BSfowOq1h9O_eYyWd-kyuQ8ms3GWxJMAqGBtIEsTGSiIsJYVzJDS9gkfFEIQYQwVoYQBl6LQBQ2BM8qZCfuFLS0wy0rG2TE63519197otW10ZZxX703XuflWkopOHe2w2x0GXZUPB43yxkFloNw-qcraKUrUxrzamlcbrUpGamteSfYLpD91CA</recordid><startdate>19870110</startdate><enddate>19870110</enddate><creator>Bell, B.A.</creator><creator>Kean, D.M.</creator><creator>Macdonald, H.L.</creator><creator>Barnett, G.H.</creator><creator>Douglas, R.H.B.</creator><creator>Smith, M.A.</creator><creator>Mcghee, C.N.J.</creator><creator>Miller, J.D.</creator><creator>Tocher, J.L.</creator><creator>Best, J.J.K.</creator><general>Elsevier Ltd</general><general>Lancet</general><scope>IQODW</scope></search><sort><creationdate>19870110</creationdate><title>BRAIN WATER MEASURED BY MAGNETIC RESONANCE IMAGING: Correlation with Direct Estimation and Changes After Mannitol and Dexamethasone</title><author>Bell, B.A. ; Kean, D.M. ; Macdonald, H.L. ; Barnett, G.H. ; Douglas, R.H.B. ; Smith, M.A. ; Mcghee, C.N.J. ; Miller, J.D. ; Tocher, J.L. ; Best, J.J.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e153t-8dc7ceb05ff3b3c0df2049b5505cc1568e9485bab16e43143c62bfdfe3f3d343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biological and medical sciences</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical sciences</topic><topic>Nervous system</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bell, B.A.</creatorcontrib><creatorcontrib>Kean, D.M.</creatorcontrib><creatorcontrib>Macdonald, H.L.</creatorcontrib><creatorcontrib>Barnett, G.H.</creatorcontrib><creatorcontrib>Douglas, R.H.B.</creatorcontrib><creatorcontrib>Smith, M.A.</creatorcontrib><creatorcontrib>Mcghee, C.N.J.</creatorcontrib><creatorcontrib>Miller, J.D.</creatorcontrib><creatorcontrib>Tocher, J.L.</creatorcontrib><creatorcontrib>Best, J.J.K.</creatorcontrib><collection>Pascal-Francis</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bell, B.A.</au><au>Kean, D.M.</au><au>Macdonald, H.L.</au><au>Barnett, G.H.</au><au>Douglas, R.H.B.</au><au>Smith, M.A.</au><au>Mcghee, C.N.J.</au><au>Miller, J.D.</au><au>Tocher, J.L.</au><au>Best, J.J.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BRAIN WATER MEASURED BY MAGNETIC RESONANCE IMAGING: Correlation with Direct Estimation and Changes After Mannitol and Dexamethasone</atitle><jtitle>The Lancet (British edition)</jtitle><date>1987-01-10</date><risdate>1987</risdate><volume>329</volume><issue>8524</issue><spage>66</spage><epage>69</epage><pages>66-69</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Brain water content was measured in tissue samples taken at operation from 19 patients with intrinsic cerebral tumours imaged preoperatively by magnetic resonance. A high correlation (r = 0·94, p<0·0001) between white matter water content and the longitudinal relaxation time (T
1) enabled water content to be estimated from T
1 to within 4%. 11 patients received dexamethasone and improved clinically but their T
1, and thus brain water content, was unchanged an average of 6 days later. Intravenous infusion of 20% mannitol in 11 patients significantly reduced T
1 in oedematous white matter and tumour within 15 min of administration, and by 30 min the T
1 of oedematous white matter had fallen to a mean of 32·4 (SEM 7·1) ms, corresponding to a reduction in water content of 1·4 (0·3)%.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><doi>10.1016/S0140-6736(87)91908-8</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0140-6736 |
| ispartof | The Lancet (British edition), 1987-01, Vol.329 (8524), p.66-69 |
| issn | 0140-6736 1474-547X |
| language | eng |
| recordid | cdi_pascalfrancis_primary_8159191 |
| source | Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Investigative techniques, diagnostic techniques (general aspects) Medical sciences Nervous system Radiodiagnosis. Nmr imagery. Nmr spectrometry |
| title | BRAIN WATER MEASURED BY MAGNETIC RESONANCE IMAGING: Correlation with Direct Estimation and Changes After Mannitol and Dexamethasone |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T22%3A17%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-elsevier_pasca&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=BRAIN%20WATER%20MEASURED%20BY%20MAGNETIC%20RESONANCE%20IMAGING:%20Correlation%20with%20Direct%20Estimation%20and%20Changes%20After%20Mannitol%20and%20Dexamethasone&rft.jtitle=The%20Lancet%20(British%20edition)&rft.au=Bell,%20B.A.&rft.date=1987-01-10&rft.volume=329&rft.issue=8524&rft.spage=66&rft.epage=69&rft.pages=66-69&rft.issn=0140-6736&rft.eissn=1474-547X&rft.coden=LANCAO&rft_id=info:doi/10.1016/S0140-6736(87)91908-8&rft_dat=%3Celsevier_pasca%3ES0140673687919088%3C/elsevier_pasca%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_els_id=S0140673687919088&rfr_iscdi=true |