Does Liver-Intestine Significantly Degrade Circulating Endogenous Substance P in Man?
Elevated concentrations of circulating substance P in patients with liver insufficiency have been ascribed to decreased hepatic degradation. To establish a possible bio-degradation of the peptide in liver-intestine and kidneys, the concentration of endogenous immunoreactive substance P was determine...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1986-01, Vol.21 (3), p.300-304 |
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| container_title | Scandinavian journal of gastroenterology |
| container_volume | 21 |
| creator | Henriksen, J. H. de Muckadell, O. B. Schaffalitzky Bülow, J. B. |
| description | Elevated concentrations of circulating substance P in patients with liver insufficiency have been ascribed to decreased hepatic degradation. To establish a possible bio-degradation of the peptide in liver-intestine and kidneys, the concentration of endogenous immunoreactive substance P was determined in various vascular beds during a right-sided catheterization in 13 subjects without liver insufficiency. All subjects had normal values of circulating substance P, and no significant difference was found between systemic plasma and hepatic venous or renal venous concentrations of substance P. The results indicate that degradation of circulating endogenous substance P in man is not confined to liver-intestine or kidney but may take place in many tissues. |
| doi_str_mv | 10.3109/00365528609003079 |
| format | Article |
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H.</creatorcontrib><creatorcontrib>de Muckadell, O. B. Schaffalitzky</creatorcontrib><creatorcontrib>Bülow, J. B.</creatorcontrib><title>Does Liver-Intestine Significantly Degrade Circulating Endogenous Substance P in Man?</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Elevated concentrations of circulating substance P in patients with liver insufficiency have been ascribed to decreased hepatic degradation. To establish a possible bio-degradation of the peptide in liver-intestine and kidneys, the concentration of endogenous immunoreactive substance P was determined in various vascular beds during a right-sided catheterization in 13 subjects without liver insufficiency. All subjects had normal values of circulating substance P, and no significant difference was found between systemic plasma and hepatic venous or renal venous concentrations of substance P. The results indicate that degradation of circulating endogenous substance P in man is not confined to liver-intestine or kidney but may take place in many tissues.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal hormones</subject><subject>Hepatosplanchnic and renal elimination</subject><subject>Humans</subject><subject>immunoreactive plasma substance P</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Substance P - blood</subject><subject>Substance P - metabolism</subject><subject>vascular extraction</subject><subject>Veins</subject><subject>Vertebrates: digestive system</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFDEUxYNY6rb6AXwQ8iC-jSaTyZ9BQWRbtbBFofV5yCQ325RsUpMZZb99U3YtSKF9uhfO71xOThB6Tcl7Rkn_gRAmOG-VIH1dieyfoQXlpG2kJOo5WtzpTQXoC3RUyjUhhMuuP0SHbdd2FV-gXycJCl75P5CbszhBmXwEfOHX0TtvdJzCFp_AOmsLeOmzmYOuxBqfRpvWENNc8MU8lklHA_gn9hGf6_j5JTpwOhR4tZ_H6PLr6eXye7P68e1s-WXVmE7QqeGUGmdZx7W1bBwZaw2zUhghmeMtF4L1VetHS1sYlSNcOQU9q2Y5dtSwY_Rud_Ymp99zzT5sfDEQgo5Qkw1SKMmUap8EaddxKQWpIN2BJqdSMrjhJvuNztuBkuGu8uFB5dXzZn98Hjdg7x37jqv-dq_rYnRwuXblyz2miBSCs4p92mE-upQ3-m_KwQ6T3oaU_3nYYyk-_me_Ah2mK6MzDNdpzrF-wyNvuAVghqzY</recordid><startdate>19860101</startdate><enddate>19860101</enddate><creator>Henriksen, J. 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B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-511cfd345add3bb332c3d76c673f525663945a9bd12eb8f058f8e93c467b41c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal hormones</topic><topic>Hepatosplanchnic and renal elimination</topic><topic>Humans</topic><topic>immunoreactive plasma substance P</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Substance P - blood</topic><topic>Substance P - metabolism</topic><topic>vascular extraction</topic><topic>Veins</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henriksen, J. H.</creatorcontrib><creatorcontrib>de Muckadell, O. B. Schaffalitzky</creatorcontrib><creatorcontrib>Bülow, J. 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B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Liver-Intestine Significantly Degrade Circulating Endogenous Substance P in Man?</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1986-01-01</date><risdate>1986</risdate><volume>21</volume><issue>3</issue><spage>300</spage><epage>304</epage><pages>300-304</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Elevated concentrations of circulating substance P in patients with liver insufficiency have been ascribed to decreased hepatic degradation. To establish a possible bio-degradation of the peptide in liver-intestine and kidneys, the concentration of endogenous immunoreactive substance P was determined in various vascular beds during a right-sided catheterization in 13 subjects without liver insufficiency. 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| fulltext | fulltext |
| identifier | ISSN: 0036-5521 |
| ispartof | Scandinavian journal of gastroenterology, 1986-01, Vol.21 (3), p.300-304 |
| issn | 0036-5521 1502-7708 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_8076653 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Aged Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Gastrointestinal hormones Hepatosplanchnic and renal elimination Humans immunoreactive plasma substance P Intestinal Mucosa - metabolism Liver - metabolism Male Middle Aged Substance P - blood Substance P - metabolism vascular extraction Veins Vertebrates: digestive system |
| title | Does Liver-Intestine Significantly Degrade Circulating Endogenous Substance P in Man? |
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