Regulation of the induction of a cytochrome P-450 prostaglandin omega-hydroxylase by pregnancy in rabbit lung

The mechanism of induction of an adult rabbit cytochrome P-450, prostaglandin (PG) ω -hydroxylase (P-450PG-ω), during pregnancy has been investigated. This P-450 isozyme regiospecifically hydroxylates PGE1, PGA1, and PGF2α at carbon-20 (the ω position). The specific activity of this enzyme is induce...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1987-11, Vol.84 (22), p.7911-7914
Hauptverfasser:	Muerhoff, A.S, Williams, D.E, Leithauser, M.T, Jackson, V.E, Waterman, M.R, Masters, B.S.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals ARN Biological and medical sciences CONEJO (ORYCTOLAGUS) Cytochrome P-450 Enzyme System - biosynthesis Cytochrome P-450 Enzyme System - genetics Cytochromes Enzyme Induction Enzymes Enzymes and enzyme inhibitors Female Fundamental and applied biological sciences. Psychology Gels GESTACION GESTATION Immunoprecipitation ISOENZIMAS ISOENZYME ISOENZYMES LAPIN Lung - enzymology LUNGS Messenger RNA METALLOPROTEINE METALLOPROTEINS METALPROTEINAS Microsomes Microsomes - enzymology Mixed Function Oxygenases - biosynthesis Mixed Function Oxygenases - genetics Oxidoreductases POUMON PREGNANCY Pregnancy, Animal - metabolism PROSTAGLANDINAS PROSTAGLANDINE PROSTAGLANDINS PULMONES RABBITS RNA RNA, Messenger - analysis
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