Familial Defective Apolipoprotein B-100: Low Density Lipoproteins with Abnormal Receptor Binding

Previous in vivo turnover studies suggested that retarded clearance of low density lipoproteins (LDL) from the plasma of some hypercholesterolemic patients is due to LDL with defective receptor binding. The present study examined this postulate directly by receptor binding experiments. The LDL from...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. U.S.A.; (United States) 1987-10, Vol.84 (19), p.6919-6923
Hauptverfasser:	Innerarity, Thomas L., Weisgraber, Karl H., Arnold, Kay S., Mahley, Robert W., Krauss, Ronald M., Vega, Gloria L., Grundy, Scott M.
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques Analytical, structural and metabolic biochemistry ANIMAL CELLS Apolipoprotein B-100 APOLIPOPROTEINS Apolipoproteins B - blood Apolipoproteins B - genetics Apolipoproteins B - metabolism BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BIODEGRADATION Biological and medical sciences Brothers Cells, Cultured CHEMICAL REACTIONS Cholesterols CONNECTIVE TISSUE CELLS DAYS LIVING RADIOISOTOPES DECOMPOSITION DISEASES ELECTRON CAPTURE RADIOISOTOPES Family members FIBROBLASTS Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology HEREDITARY DISEASES Heterozygotes Humans Hypercholesterolemia Hyperlipoproteinemia Type II - blood Hyperlipoproteinemia Type II - genetics Infant INTERMEDIATE MASS NUCLEI IODINE 125 IODINE ISOTOPES ISOTOPES Kinetics LABELLED COMPOUNDS LIPIDS LIPOPROTEINS Lipoproteins, LDL - blood Lipoproteins, myelin Male man MEMBRANE PROTEINS NUCLEI ODD-EVEN NUCLEI ORGANIC COMPOUNDS PATIENTS PROTEINS RADIOISOTOPES RECEPTORS Receptors, LDL - metabolism SOMATIC CELLS Sons UPTAKE
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