Inner Ear Disturbances following Inoculation of Endotoxin into the Middle Ear
Inner ear function was assessed by a frequency-specific (±100 Hz) auditory brainstem response (ABR) technique after a single instillation of a suspension of purified E. coli lipopolysaccharide in sterile water into the round window (RW) niche in rats. Instillation of endotoxin caused a transient con...
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| Veröffentlicht in: | Acta oto-laryngologica 1989, Vol.107 (1-2), p.90-96 |
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| container_title | Acta oto-laryngologica |
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| creator | Spandow, Odd Anniko, Matti Hellström, Sten |
| description | Inner ear function was assessed by a frequency-specific (±100 Hz) auditory brainstem response (ABR) technique after a single instillation of a suspension of purified E. coli lipopolysaccharide in sterile water into the round window (RW) niche in rats. Instillation of endotoxin caused a transient concentration and tonotopically dependent dysfunction of the inner ear. The largest threshold impairment occurred in the high-frequency region anatomically located close to the RW. At 31.5 kHz the threshold impairment persisted throughout the study. Morphologic damage to the inner ear was not detected at the light microscopic level when using serial sections from decalcified specimens. Our study supports the clinical hypothesis that remnants of non-viable bacteria such as endotoxins, when trapped in the middle ear, can promote middle ear effusion and dysfunction of the inner ear. |
| doi_str_mv | 10.3109/00016488909127484 |
| format | Article |
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Instillation of endotoxin caused a transient concentration and tonotopically dependent dysfunction of the inner ear. The largest threshold impairment occurred in the high-frequency region anatomically located close to the RW. At 31.5 kHz the threshold impairment persisted throughout the study. Morphologic damage to the inner ear was not detected at the light microscopic level when using serial sections from decalcified specimens. Our study supports the clinical hypothesis that remnants of non-viable bacteria such as endotoxins, when trapped in the middle ear, can promote middle ear effusion and dysfunction of the inner ear.</description><identifier>ISSN: 0001-6489</identifier><identifier>EISSN: 1651-2251</identifier><identifier>DOI: 10.3109/00016488909127484</identifier><identifier>PMID: 2648747</identifier><identifier>CODEN: AOLAAJ</identifier><language>eng</language><publisher>Stockholm: Informa UK Ltd</publisher><subject>Animals ; Bacterial Toxins - administration & dosage ; Bacterial Toxins - toxicity ; Biological and medical sciences ; Dose-Response Relationship, Drug ; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology ; Ear, Inner - pathology ; Ear, Inner - physiopathology ; electrophysiology ; endotoxin ; Enterotoxins - administration & dosage ; Enterotoxins - toxicity ; Escherichia coli ; Escherichia coli Proteins ; Evoked Potentials, Auditory ; inner ear function ; Male ; Medical sciences ; Non tumoral diseases ; Otorhinolaryngology. Stomatology ; rat ; Rats ; Rats, Inbred Strains ; Round Window, Ear</subject><ispartof>Acta oto-laryngologica, 1989, Vol.107 (1-2), p.90-96</ispartof><rights>1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1989</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-567ae939c690dffb8e2370864c127238ffae7ac5ffdcd1525c3f26a82b133b903</citedby><cites>FETCH-LOGICAL-c490t-567ae939c690dffb8e2370864c127238ffae7ac5ffdcd1525c3f26a82b133b903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00016488909127484$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00016488909127484$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7116621$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2648747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spandow, Odd</creatorcontrib><creatorcontrib>Anniko, Matti</creatorcontrib><creatorcontrib>Hellström, Sten</creatorcontrib><title>Inner Ear Disturbances following Inoculation of Endotoxin into the Middle Ear</title><title>Acta oto-laryngologica</title><addtitle>Acta Otolaryngol</addtitle><description>Inner ear function was assessed by a frequency-specific (±100 Hz) auditory brainstem response (ABR) technique after a single instillation of a suspension of purified E. coli lipopolysaccharide in sterile water into the round window (RW) niche in rats. Instillation of endotoxin caused a transient concentration and tonotopically dependent dysfunction of the inner ear. The largest threshold impairment occurred in the high-frequency region anatomically located close to the RW. At 31.5 kHz the threshold impairment persisted throughout the study. Morphologic damage to the inner ear was not detected at the light microscopic level when using serial sections from decalcified specimens. Our study supports the clinical hypothesis that remnants of non-viable bacteria such as endotoxins, when trapped in the middle ear, can promote middle ear effusion and dysfunction of the inner ear.</description><subject>Animals</subject><subject>Bacterial Toxins - administration & dosage</subject><subject>Bacterial Toxins - toxicity</subject><subject>Biological and medical sciences</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</subject><subject>Ear, Inner - pathology</subject><subject>Ear, Inner - physiopathology</subject><subject>electrophysiology</subject><subject>endotoxin</subject><subject>Enterotoxins - administration & dosage</subject><subject>Enterotoxins - toxicity</subject><subject>Escherichia coli</subject><subject>Escherichia coli Proteins</subject><subject>Evoked Potentials, Auditory</subject><subject>inner ear function</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Round Window, Ear</subject><issn>0001-6489</issn><issn>1651-2251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEUhYMoWh8_wIWQhbgbzWMeCboRrVqouNH1kMkkNpImmmSo_femtAoiuLrknu8ccg8AxxidU4z4BUII1yVjHHFMmpKVW2CE6woXhFR4G4xWepEBvgf2Y3xbPTmrdsEuycumbEbgceKcCnAsArw1MQ2hE06qCLW31i-Me4UT5-VgRTLeQa_h2PU--U_joHHJwzRT8NH0vVWrjEOwo4WN6mgzD8DL3fj55qGYPt1Pbq6nhSw5SkVVN0JxymXNUa91xxShDWJ1KfMVhDKthWqErLTuZY8rUkmqSS0Y6TClHUf0AJytc9-D_xhUTO3cRKmsFU75IbbZw1hFeAbxGpTBxxiUbt-DmYuwbDFqVxW2fyrMnpNN-NDNVf_j2HSW9dONLqIUVofcmIk_WINxXROcsas1Zpz2YS4WPti-TWJpffj20P9-cfnLPlPCppkUQbVvfggu1_vPDV8qNZ1z</recordid><startdate>1989</startdate><enddate>1989</enddate><creator>Spandow, Odd</creator><creator>Anniko, Matti</creator><creator>Hellström, Sten</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Taylor and Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>1989</creationdate><title>Inner Ear Disturbances following Inoculation of Endotoxin into the Middle Ear</title><author>Spandow, Odd ; Anniko, Matti ; Hellström, Sten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-567ae939c690dffb8e2370864c127238ffae7ac5ffdcd1525c3f26a82b133b903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>Animals</topic><topic>Bacterial Toxins - administration & dosage</topic><topic>Bacterial Toxins - toxicity</topic><topic>Biological and medical sciences</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology</topic><topic>Ear, Inner - pathology</topic><topic>Ear, Inner - physiopathology</topic><topic>electrophysiology</topic><topic>endotoxin</topic><topic>Enterotoxins - administration & dosage</topic><topic>Enterotoxins - toxicity</topic><topic>Escherichia coli</topic><topic>Escherichia coli Proteins</topic><topic>Evoked Potentials, Auditory</topic><topic>inner ear function</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Round Window, Ear</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spandow, Odd</creatorcontrib><creatorcontrib>Anniko, Matti</creatorcontrib><creatorcontrib>Hellström, Sten</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Acta oto-laryngologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spandow, Odd</au><au>Anniko, Matti</au><au>Hellström, Sten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inner Ear Disturbances following Inoculation of Endotoxin into the Middle Ear</atitle><jtitle>Acta oto-laryngologica</jtitle><addtitle>Acta Otolaryngol</addtitle><date>1989</date><risdate>1989</risdate><volume>107</volume><issue>1-2</issue><spage>90</spage><epage>96</epage><pages>90-96</pages><issn>0001-6489</issn><eissn>1651-2251</eissn><coden>AOLAAJ</coden><abstract>Inner ear function was assessed by a frequency-specific (±100 Hz) auditory brainstem response (ABR) technique after a single instillation of a suspension of purified E. coli lipopolysaccharide in sterile water into the round window (RW) niche in rats. Instillation of endotoxin caused a transient concentration and tonotopically dependent dysfunction of the inner ear. The largest threshold impairment occurred in the high-frequency region anatomically located close to the RW. At 31.5 kHz the threshold impairment persisted throughout the study. Morphologic damage to the inner ear was not detected at the light microscopic level when using serial sections from decalcified specimens. Our study supports the clinical hypothesis that remnants of non-viable bacteria such as endotoxins, when trapped in the middle ear, can promote middle ear effusion and dysfunction of the inner ear.</abstract><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>2648747</pmid><doi>10.3109/00016488909127484</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6489 |
| ispartof | Acta oto-laryngologica, 1989, Vol.107 (1-2), p.90-96 |
| issn | 0001-6489 1651-2251 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_7116621 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Bacterial Toxins - administration & dosage Bacterial Toxins - toxicity Biological and medical sciences Dose-Response Relationship, Drug Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology Ear, Inner - pathology Ear, Inner - physiopathology electrophysiology endotoxin Enterotoxins - administration & dosage Enterotoxins - toxicity Escherichia coli Escherichia coli Proteins Evoked Potentials, Auditory inner ear function Male Medical sciences Non tumoral diseases Otorhinolaryngology. Stomatology rat Rats Rats, Inbred Strains Round Window, Ear |
| title | Inner Ear Disturbances following Inoculation of Endotoxin into the Middle Ear |
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