Determination of Suramin in Plasma and Urine by Ion-Paired Reverse-Phase High-Performance Liquid Chromatography
A high-pressure liquid chromatographic (HPLC) assay has been developed for the quantification of the anti-viral drug suramin (SUR) in human plasma and urine. This assay is simple and accurate, using an isocratic mobile phase in a reverse-phase ion-pairing mode. This assay was developed for the deter...
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| Veröffentlicht in: | Journal of liquid chromatography 1987-11, Vol.10 (15), p.3451-3462 |
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| container_end_page | 3462 |
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| container_issue | 15 |
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| container_title | Journal of liquid chromatography |
| container_volume | 10 |
| creator | Stolzer, Thomas J. Lafollette, Greg Gambertoglio, John Aweeka, Francesca Lin, Emil T. |
| description | A high-pressure liquid chromatographic (HPLC) assay has been developed for the quantification of the anti-viral drug suramin (SUR) in human plasma and urine. This assay is simple and accurate, using an isocratic mobile phase in a reverse-phase ion-pairing mode.
This assay was developed for the determination of high levels of suramin in the urine and plasma of patients being treated for the acquired immunodefficiency Syndrome (AIDS). The limit of detection of this assay was 0.25 μg/mL. Congo red (CR) was used as the internal standard with a retention time of 5.9 min, while suramin had a retention time of 13 min. |
| doi_str_mv | 10.1080/01483918708081883 |
| format | Article |
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This assay was developed for the determination of high levels of suramin in the urine and plasma of patients being treated for the acquired immunodefficiency Syndrome (AIDS). The limit of detection of this assay was 0.25 μg/mL. Congo red (CR) was used as the internal standard with a retention time of 5.9 min, while suramin had a retention time of 13 min.</description><identifier>ISSN: 0148-3919</identifier><identifier>EISSN: 2331-0413</identifier><identifier>DOI: 10.1080/01483918708081883</identifier><identifier>CODEN: JLCHD8</identifier><language>eng</language><publisher>New York, NY: Taylor & Francis Group</publisher><subject>Analysis ; Biological and medical sciences ; General pharmacology ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Journal of liquid chromatography, 1987-11, Vol.10 (15), p.3451-3462</ispartof><rights>Copyright Taylor & Francis Group, LLC 1987</rights><rights>1989 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c325t-da5ec95ed29dcc8286c272e696bf505159a78f2970f9a215b9c316fd7543d3c33</citedby><cites>FETCH-LOGICAL-c325t-da5ec95ed29dcc8286c272e696bf505159a78f2970f9a215b9c316fd7543d3c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/01483918708081883$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/01483918708081883$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,60436</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7035506$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Stolzer, Thomas J.</creatorcontrib><creatorcontrib>Lafollette, Greg</creatorcontrib><creatorcontrib>Gambertoglio, John</creatorcontrib><creatorcontrib>Aweeka, Francesca</creatorcontrib><creatorcontrib>Lin, Emil T.</creatorcontrib><title>Determination of Suramin in Plasma and Urine by Ion-Paired Reverse-Phase High-Performance Liquid Chromatography</title><title>Journal of liquid chromatography</title><description>A high-pressure liquid chromatographic (HPLC) assay has been developed for the quantification of the anti-viral drug suramin (SUR) in human plasma and urine. This assay is simple and accurate, using an isocratic mobile phase in a reverse-phase ion-pairing mode.
This assay was developed for the determination of high levels of suramin in the urine and plasma of patients being treated for the acquired immunodefficiency Syndrome (AIDS). The limit of detection of this assay was 0.25 μg/mL. Congo red (CR) was used as the internal standard with a retention time of 5.9 min, while suramin had a retention time of 13 min.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0148-3919</issn><issn>2331-0413</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNp1UE1LAzEQDaJgqf0B3nLwuppsNrsJeJH60ULBova8TPPRjexuarJV9t-7tepFHAaGx7w3w3sInVNySYkgV4RmgkkqigEIKgQ7QqOUMZqQjLJjNNrvk4EgT9EkxlcyFM-KLBcj5G9NZ0LjWuicb7G3-HkXYMB46GUNsQEMrcar4FqD1z2e-zZZggtG4yfzbkI0ybKCaPDMbapkaYL1oYFWGbxwbzun8bQKvoHObwJsq_4MnVioo5l8zzFa3d-9TGfJ4vFhPr1ZJIqlvEs0cKMkNzqVWimRilylRWpyma8tJ5xyCYWwqSyIlZBSvpaK0dzqgmdMM8XYGNHDXRV8jMHYchtcA6EvKSn3oZV_Qhs0FwfNFqKC2obBhou_woIwzkk-0K4PNNd-ef3wodZlB33tw4-G_f_lExMDfwo</recordid><startdate>19871101</startdate><enddate>19871101</enddate><creator>Stolzer, Thomas J.</creator><creator>Lafollette, Greg</creator><creator>Gambertoglio, John</creator><creator>Aweeka, Francesca</creator><creator>Lin, Emil T.</creator><general>Taylor & Francis Group</general><general>Dekker</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19871101</creationdate><title>Determination of Suramin in Plasma and Urine by Ion-Paired Reverse-Phase High-Performance Liquid Chromatography</title><author>Stolzer, Thomas J. ; Lafollette, Greg ; Gambertoglio, John ; Aweeka, Francesca ; Lin, Emil T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-da5ec95ed29dcc8286c272e696bf505159a78f2970f9a215b9c316fd7543d3c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>online_resources</toplevel><creatorcontrib>Stolzer, Thomas J.</creatorcontrib><creatorcontrib>Lafollette, Greg</creatorcontrib><creatorcontrib>Gambertoglio, John</creatorcontrib><creatorcontrib>Aweeka, Francesca</creatorcontrib><creatorcontrib>Lin, Emil T.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Journal of liquid chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stolzer, Thomas J.</au><au>Lafollette, Greg</au><au>Gambertoglio, John</au><au>Aweeka, Francesca</au><au>Lin, Emil T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Suramin in Plasma and Urine by Ion-Paired Reverse-Phase High-Performance Liquid Chromatography</atitle><jtitle>Journal of liquid chromatography</jtitle><date>1987-11-01</date><risdate>1987</risdate><volume>10</volume><issue>15</issue><spage>3451</spage><epage>3462</epage><pages>3451-3462</pages><issn>0148-3919</issn><eissn>2331-0413</eissn><coden>JLCHD8</coden><abstract>A high-pressure liquid chromatographic (HPLC) assay has been developed for the quantification of the anti-viral drug suramin (SUR) in human plasma and urine. This assay is simple and accurate, using an isocratic mobile phase in a reverse-phase ion-pairing mode.
This assay was developed for the determination of high levels of suramin in the urine and plasma of patients being treated for the acquired immunodefficiency Syndrome (AIDS). The limit of detection of this assay was 0.25 μg/mL. Congo red (CR) was used as the internal standard with a retention time of 5.9 min, while suramin had a retention time of 13 min.</abstract><cop>New York, NY</cop><pub>Taylor & Francis Group</pub><doi>10.1080/01483918708081883</doi><tpages>12</tpages></addata></record> |
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| subjects | Analysis Biological and medical sciences General pharmacology Medical sciences Pharmacology. Drug treatments |
| title | Determination of Suramin in Plasma and Urine by Ion-Paired Reverse-Phase High-Performance Liquid Chromatography |
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