Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization
The gene encoding the fusogenic spike protein of the coronavirus causing feline infectious peritonitis was recombined into the genome of vaccinia virus. The recombinant induced spike-protein-specific, in vitro neutralizing antibodies in mice. When kittens were immunized with the recombinant, low tit...
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| Veröffentlicht in: | Journal of Virology 1990-03, Vol.64 (3), p.1407-1409 |
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| container_issue | 3 |
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| container_title | Journal of Virology |
| container_volume | 64 |
| creator | VENNEMA, H DE GROOT, R. J HARBOUR, D. A DALDERUP, M GRUFFYDD-JONES, T HORZINEK, M. C SPAAN, W. J. M |
| description | The gene encoding the fusogenic spike protein of the coronavirus causing feline infectious peritonitis was recombined into the genome of vaccinia virus. The recombinant induced spike-protein-specific, in vitro neutralizing antibodies in mice. When kittens were immunized with the recombinant, low titers of neutralizing antibodies were obtained. After challenge with feline infectious peritonitis virus, these animals succumbed earlier than did the control group immunized with wild-type vaccinia virus (early death syndrome). |
| doi_str_mv | 10.1128/jvi.64.3.1407-1409.1990 |
| format | Article |
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J ; HARBOUR, D. A ; DALDERUP, M ; GRUFFYDD-JONES, T ; HORZINEK, M. C ; SPAAN, W. J. M</creator><creatorcontrib>VENNEMA, H ; DE GROOT, R. J ; HARBOUR, D. A ; DALDERUP, M ; GRUFFYDD-JONES, T ; HORZINEK, M. C ; SPAAN, W. J. M ; State University of Utrecht, Utrecht, The Netherlands</creatorcontrib><description>The gene encoding the fusogenic spike protein of the coronavirus causing feline infectious peritonitis was recombined into the genome of vaccinia virus. The recombinant induced spike-protein-specific, in vitro neutralizing antibodies in mice. When kittens were immunized with the recombinant, low titers of neutralizing antibodies were obtained. After challenge with feline infectious peritonitis virus, these animals succumbed earlier than did the control group immunized with wild-type vaccinia virus (early death syndrome).</description><identifier>ISSN: 0022-538X</identifier><identifier>EISSN: 1098-5514</identifier><identifier>DOI: 10.1128/jvi.64.3.1407-1409.1990</identifier><identifier>PMID: 2154621</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Animals ; Antibodies, Viral - immunology ; Antibody Formation ; Biological and medical sciences ; Cat Diseases - immunology ; Cat Diseases - microbiology ; Cat Diseases - mortality ; Cats ; chat ; coronaviridae ; Coronaviridae - genetics ; Coronaviridae - immunology ; Coronaviridae Infections - immunology ; Coronaviridae Infections - mortality ; Coronaviridae Infections - veterinary ; Fundamental and applied biological sciences. Psychology ; gato ; Genes, Viral ; immunisation ; immunization ; Immunization, Passive ; inmunizacion ; Mice ; Microbiology ; Neutralization Tests ; orthopoxvirus ; peritonite ; peritonitis ; Peritonitis - immunology ; Peritonitis - mortality ; Peritonitis - veterinary ; recombinacion ; recombinaison ; Recombinant Proteins - immunology ; recombination ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; vaccinia virus ; Vaccinia virus - genetics ; Viral Proteins - genetics ; Viral Proteins - immunology ; Virology</subject><ispartof>Journal of Virology, 1990-03, Vol.64 (3), p.1407-1409</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c586t-412236a597a42110ad82c03fc125713fe6c9e9e5a7775529b9eeea74b59ab69c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC249267/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC249267/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6830292$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2154621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VENNEMA, H</creatorcontrib><creatorcontrib>DE GROOT, R. J</creatorcontrib><creatorcontrib>HARBOUR, D. A</creatorcontrib><creatorcontrib>DALDERUP, M</creatorcontrib><creatorcontrib>GRUFFYDD-JONES, T</creatorcontrib><creatorcontrib>HORZINEK, M. C</creatorcontrib><creatorcontrib>SPAAN, W. J. M</creatorcontrib><creatorcontrib>State University of Utrecht, Utrecht, The Netherlands</creatorcontrib><title>Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization</title><title>Journal of Virology</title><addtitle>J Virol</addtitle><description>The gene encoding the fusogenic spike protein of the coronavirus causing feline infectious peritonitis was recombined into the genome of vaccinia virus. The recombinant induced spike-protein-specific, in vitro neutralizing antibodies in mice. When kittens were immunized with the recombinant, low titers of neutralizing antibodies were obtained. After challenge with feline infectious peritonitis virus, these animals succumbed earlier than did the control group immunized with wild-type vaccinia virus (early death syndrome).</description><subject>Animals</subject><subject>Antibodies, Viral - immunology</subject><subject>Antibody Formation</subject><subject>Biological and medical sciences</subject><subject>Cat Diseases - immunology</subject><subject>Cat Diseases - microbiology</subject><subject>Cat Diseases - mortality</subject><subject>Cats</subject><subject>chat</subject><subject>coronaviridae</subject><subject>Coronaviridae - genetics</subject><subject>Coronaviridae - immunology</subject><subject>Coronaviridae Infections - immunology</subject><subject>Coronaviridae Infections - mortality</subject><subject>Coronaviridae Infections - veterinary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gato</subject><subject>Genes, Viral</subject><subject>immunisation</subject><subject>immunization</subject><subject>Immunization, Passive</subject><subject>inmunizacion</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Neutralization Tests</subject><subject>orthopoxvirus</subject><subject>peritonite</subject><subject>peritonitis</subject><subject>Peritonitis - immunology</subject><subject>Peritonitis - mortality</subject><subject>Peritonitis - veterinary</subject><subject>recombinacion</subject><subject>recombinaison</subject><subject>Recombinant Proteins - immunology</subject><subject>recombination</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>vaccinia virus</subject><subject>Vaccinia virus - genetics</subject><subject>Viral Proteins - genetics</subject><subject>Viral Proteins - immunology</subject><subject>Virology</subject><issn>0022-538X</issn><issn>1098-5514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhiMEKkvhJwBBQtwS_O34wAFV5UOqxAEqcbMm3smuq8RZ7GRR-fU42mhFT1zGkt_nHY_nLYrXlNSUsub93dHXStS8poLoKhdTU2PIo2JDiWkqKal4XGwIYaySvPn5tHiW0h0hVAglLooLRqVQjG6KcA2xvy-3CNO-hG7CWHbY-4ClDx26yY9zKg8Y_TQGP_lUHn3MN24PfY9hh-V2xnIay4huHFofIEzlEZzzwcPK-mGYg_8DuVd4XjzpoE_4Yj0vi9tP1z-uvlQ33z5_vfp4UznZqKkSlDGuQBoNglFKYNswR3jnKJOa8g6VM2hQgtZaSmZag4igRSsNtMo4fll8OPU9zO2AW4dhitDbQ_QDxHs7grcPleD3djceLROGKZ3971Z_HH_NmCY7-OSw7yFg3ojVRlEjifkvmPesG8JpBvUJdHFMKWJ3HoYSu0Rqc6RWCcvtEulSjF0izc6X__7l7FszzPrbVYfkoO8iBOfTGVMNJ8ywjL05YXu_2__2ES2k4eGjmXl1YjoYLexibnP7fRmCEN1wrvhf26nCMg</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>VENNEMA, H</creator><creator>DE GROOT, R. J</creator><creator>HARBOUR, D. A</creator><creator>DALDERUP, M</creator><creator>GRUFFYDD-JONES, T</creator><creator>HORZINEK, M. C</creator><creator>SPAAN, W. J. M</creator><general>American Society for Microbiology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19900301</creationdate><title>Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization</title><author>VENNEMA, H ; DE GROOT, R. J ; HARBOUR, D. A ; DALDERUP, M ; GRUFFYDD-JONES, T ; HORZINEK, M. C ; SPAAN, W. J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c586t-412236a597a42110ad82c03fc125713fe6c9e9e5a7775529b9eeea74b59ab69c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Antibodies, Viral - immunology</topic><topic>Antibody Formation</topic><topic>Biological and medical sciences</topic><topic>Cat Diseases - immunology</topic><topic>Cat Diseases - microbiology</topic><topic>Cat Diseases - mortality</topic><topic>Cats</topic><topic>chat</topic><topic>coronaviridae</topic><topic>Coronaviridae - genetics</topic><topic>Coronaviridae - immunology</topic><topic>Coronaviridae Infections - immunology</topic><topic>Coronaviridae Infections - mortality</topic><topic>Coronaviridae Infections - veterinary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gato</topic><topic>Genes, Viral</topic><topic>immunisation</topic><topic>immunization</topic><topic>Immunization, Passive</topic><topic>inmunizacion</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Neutralization Tests</topic><topic>orthopoxvirus</topic><topic>peritonite</topic><topic>peritonitis</topic><topic>Peritonitis - immunology</topic><topic>Peritonitis - mortality</topic><topic>Peritonitis - veterinary</topic><topic>recombinacion</topic><topic>recombinaison</topic><topic>Recombinant Proteins - immunology</topic><topic>recombination</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>vaccinia virus</topic><topic>Vaccinia virus - genetics</topic><topic>Viral Proteins - genetics</topic><topic>Viral Proteins - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VENNEMA, H</creatorcontrib><creatorcontrib>DE GROOT, R. J</creatorcontrib><creatorcontrib>HARBOUR, D. A</creatorcontrib><creatorcontrib>DALDERUP, M</creatorcontrib><creatorcontrib>GRUFFYDD-JONES, T</creatorcontrib><creatorcontrib>HORZINEK, M. C</creatorcontrib><creatorcontrib>SPAAN, W. J. M</creatorcontrib><creatorcontrib>State University of Utrecht, Utrecht, The Netherlands</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VENNEMA, H</au><au>DE GROOT, R. J</au><au>HARBOUR, D. A</au><au>DALDERUP, M</au><au>GRUFFYDD-JONES, T</au><au>HORZINEK, M. C</au><au>SPAAN, W. J. M</au><aucorp>State University of Utrecht, Utrecht, The Netherlands</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization</atitle><jtitle>Journal of Virology</jtitle><addtitle>J Virol</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>64</volume><issue>3</issue><spage>1407</spage><epage>1409</epage><pages>1407-1409</pages><issn>0022-538X</issn><eissn>1098-5514</eissn><abstract>The gene encoding the fusogenic spike protein of the coronavirus causing feline infectious peritonitis was recombined into the genome of vaccinia virus. The recombinant induced spike-protein-specific, in vitro neutralizing antibodies in mice. When kittens were immunized with the recombinant, low titers of neutralizing antibodies were obtained. After challenge with feline infectious peritonitis virus, these animals succumbed earlier than did the control group immunized with wild-type vaccinia virus (early death syndrome).</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>2154621</pmid><doi>10.1128/jvi.64.3.1407-1409.1990</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0022-538X |
| ispartof | Journal of Virology, 1990-03, Vol.64 (3), p.1407-1409 |
| issn | 0022-538X 1098-5514 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_6830292 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Antibodies, Viral - immunology Antibody Formation Biological and medical sciences Cat Diseases - immunology Cat Diseases - microbiology Cat Diseases - mortality Cats chat coronaviridae Coronaviridae - genetics Coronaviridae - immunology Coronaviridae Infections - immunology Coronaviridae Infections - mortality Coronaviridae Infections - veterinary Fundamental and applied biological sciences. Psychology gato Genes, Viral immunisation immunization Immunization, Passive inmunizacion Mice Microbiology Neutralization Tests orthopoxvirus peritonite peritonitis Peritonitis - immunology Peritonitis - mortality Peritonitis - veterinary recombinacion recombinaison Recombinant Proteins - immunology recombination Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies vaccinia virus Vaccinia virus - genetics Viral Proteins - genetics Viral Proteins - immunology Virology |
| title | Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization |
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