Biomedical applications of chromatographic fraction containing trehalose dimycolate in squalane emulsion
Trehalose dimycolate extracted from mycobacteria is a potent immunomodulator. Incorporation of trehalose dimycolate in a squalane-in-water emulsion leads predominantly to the formation of vesicular structures, which are observable by electron microscopy. The interaction between vesicles of trehalose...
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| Veröffentlicht in: | Journal of chromatography 1988-05, Vol.440, p.473-478 |
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| container_title | Journal of chromatography |
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| creator | MASIHI, K. N LANGE, W ÖZEL, M |
| description | Trehalose dimycolate extracted from mycobacteria is a potent immunomodulator. Incorporation of trehalose dimycolate in a squalane-in-water emulsion leads predominantly to the formation of vesicular structures, which are observable by electron microscopy. The interaction between vesicles of trehalose dimycolate and the immunocompetent cells results in an enhancement of the host defence mechanisms and induction of non-specific resistance against viral, parasitic, and bacterial pathogens and certain tumors. A brief review of the pertinent observations is presented. |
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N</creatorcontrib><creatorcontrib>LANGE, W</creatorcontrib><creatorcontrib>ÖZEL, M</creatorcontrib><title>Biomedical applications of chromatographic fraction containing trehalose dimycolate in squalane emulsion</title><title>Journal of chromatography</title><addtitle>J Chromatogr</addtitle><description>Trehalose dimycolate extracted from mycobacteria is a potent immunomodulator. Incorporation of trehalose dimycolate in a squalane-in-water emulsion leads predominantly to the formation of vesicular structures, which are observable by electron microscopy. The interaction between vesicles of trehalose dimycolate and the immunocompetent cells results in an enhancement of the host defence mechanisms and induction of non-specific resistance against viral, parasitic, and bacterial pathogens and certain tumors. 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| identifier | ISSN: 0021-9673 |
| ispartof | Journal of chromatography, 1988-05, Vol.440, p.473-478 |
| issn | 0021-9673 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adjuvants, Immunologic Analytical biochemistry: general aspects, technics, instrumentation Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Chromatography Cord Factors - administration & dosage Cord Factors - pharmacology Emulsions Fundamental and applied biological sciences. Psychology Glycolipids - pharmacology Humans Squalene - analogs & derivatives Squalene - pharmacology |
| title | Biomedical applications of chromatographic fraction containing trehalose dimycolate in squalane emulsion |
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