A family of cyclin homologs that control the G1 phase in yeast
Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. C...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1989-08, Vol.86 (16), p.6255-6259 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Hadwiger, J.A. (University of California-San Diego, La Jolla, CA) Wittenberg, C Richardson, H.E Barros Lopes, M. de Reed, S.I |
| description | Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by a dramatic periodicity of abundance through the cell cycle, are thought to be involved in mitotic induction in animal cells. A dominant mutation in the CLN2 gene, CLN2-1, advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals, suggesting that the encoded protein is involved in G1 control of the cell cycle in Saccharomyces. |
| doi_str_mv | 10.1073/pnas.86.16.6255 |
| format | Article |
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(University of California-San Diego, La Jolla, CA) ; Wittenberg, C ; Richardson, H.E ; Barros Lopes, M. de ; Reed, S.I</creator><creatorcontrib>Hadwiger, J.A. (University of California-San Diego, La Jolla, CA) ; Wittenberg, C ; Richardson, H.E ; Barros Lopes, M. de ; Reed, S.I</creatorcontrib><description>Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by a dramatic periodicity of abundance through the cell cycle, are thought to be involved in mitotic induction in animal cells. A dominant mutation in the CLN2 gene, CLN2-1, advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals, suggesting that the encoded protein is involved in G1 control of the cell cycle in Saccharomyces.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.86.16.6255</identifier><identifier>PMID: 2569741</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>ADN ; Amino Acid Sequence ; Autoantigens - genetics ; Biological and medical sciences ; Cell cycle ; CELL DIVISION ; Cell growth ; Cells ; CODE GENETIQUE ; CODIGO GENETICO ; Cyclins ; DIVISION CELLULAIRE ; DIVISION CELULAR ; DNA ; DNA Transposable Elements ; DNA, Fungal - genetics ; DNA, Fungal - isolation & purification ; Fundamental and applied biological sciences. Psychology ; Genes ; Genes, Fungal ; Genes. Genome ; GENETIC CODE ; GENETIC ENGINEERING ; Genetic mutation ; GENIE GENETIQUE ; Haploidy ; Humans ; INGENIERIA GENETICA ; Interphase ; LEVADURA ; LEVURE ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Multigene Family ; MUTACION ; MUTATION ; Nuclear Proteins - genetics ; PEPTIDE ; PEPTIDES ; PEPTIDOS ; Phenotypes ; Plasmids ; Proliferating Cell Nuclear Antigen ; Protein Kinases - genetics ; PROTEINAS ; PROTEINE ; PROTEINS ; SACCHAROMYCES CEREVISIAE ; Saccharomyces cerevisiae - cytology ; Saccharomyces cerevisiae - genetics ; Sequence Homology, Nucleic Acid ; Tripeptidyl-Peptidase 1 ; YEASTS</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1989-08, Vol.86 (16), p.6255-6259</ispartof><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-7f24b5622e0bf8753db5db848cdfe5d0626aae32534ac14ddbfa85b7ec9771473</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/86/16.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/34305$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/34305$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6612877$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2569741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hadwiger, J.A. (University of California-San Diego, La Jolla, CA)</creatorcontrib><creatorcontrib>Wittenberg, C</creatorcontrib><creatorcontrib>Richardson, H.E</creatorcontrib><creatorcontrib>Barros Lopes, M. de</creatorcontrib><creatorcontrib>Reed, S.I</creatorcontrib><title>A family of cyclin homologs that control the G1 phase in yeast</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by a dramatic periodicity of abundance through the cell cycle, are thought to be involved in mitotic induction in animal cells. A dominant mutation in the CLN2 gene, CLN2-1, advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals, suggesting that the encoded protein is involved in G1 control of the cell cycle in Saccharomyces.</description><subject>ADN</subject><subject>Amino Acid Sequence</subject><subject>Autoantigens - genetics</subject><subject>Biological and medical sciences</subject><subject>Cell cycle</subject><subject>CELL DIVISION</subject><subject>Cell growth</subject><subject>Cells</subject><subject>CODE GENETIQUE</subject><subject>CODIGO GENETICO</subject><subject>Cyclins</subject><subject>DIVISION CELLULAIRE</subject><subject>DIVISION CELULAR</subject><subject>DNA</subject><subject>DNA Transposable Elements</subject><subject>DNA, Fungal - genetics</subject><subject>DNA, Fungal - isolation & purification</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes</subject><subject>Genes, Fungal</subject><subject>Genes. Genome</subject><subject>GENETIC CODE</subject><subject>GENETIC ENGINEERING</subject><subject>Genetic mutation</subject><subject>GENIE GENETIQUE</subject><subject>Haploidy</subject><subject>Humans</subject><subject>INGENIERIA GENETICA</subject><subject>Interphase</subject><subject>LEVADURA</subject><subject>LEVURE</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>MUTACION</subject><subject>MUTATION</subject><subject>Nuclear Proteins - genetics</subject><subject>PEPTIDE</subject><subject>PEPTIDES</subject><subject>PEPTIDOS</subject><subject>Phenotypes</subject><subject>Plasmids</subject><subject>Proliferating Cell Nuclear Antigen</subject><subject>Protein Kinases - genetics</subject><subject>PROTEINAS</subject><subject>PROTEINE</subject><subject>PROTEINS</subject><subject>SACCHAROMYCES CEREVISIAE</subject><subject>Saccharomyces cerevisiae - cytology</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>Tripeptidyl-Peptidase 1</subject><subject>YEASTS</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1989</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9rFDEcxYModa2eBUGZg-hptkkmPw8VStEqFDxoz-E7mWR3SmayJrPi_vdm2HG1F08hvM_7fl9eEHpJ8Jpg2VzsRshrJdZErAXl_BFaEaxJLZjGj9EKYyprxSh7ip7lfI8x1lzhM3RGudCSkRX6cFV5GPpwqKKv7MGGfqy2cYghbnI1bWGqbBynFEO5uOqGVLstZFcV6uAgT8_REw8huxfLeY7uPn38fv25vv168-X66ra2HOuplp6ylgtKHW69krzpWt61iinbecc7LKgAcA3lDQNLWNe1HhRvpbNaSsJkc44uj3N3-3ZwnXUlEwSzS_0A6WAi9OahMvZbs4k_DdVSEVH87xZ_ij_2Lk9m6LN1IcDo4j4bqQmnjM7gxRG0KeacnD_tINjMjZu5caOEIcLMjRfH63-jnfil4qK_XXTIFoJPMNo-nzAhCFVyfuGbBZvn_1Ef7Hn_X8D4fQiT-zUV8tWRvM9TTCe0YQ3mf0UP0cAmlSh33zTGrHxU8xvN_7L0</recordid><startdate>19890801</startdate><enddate>19890801</enddate><creator>Hadwiger, J.A. (University of California-San Diego, La Jolla, CA)</creator><creator>Wittenberg, C</creator><creator>Richardson, H.E</creator><creator>Barros Lopes, M. de</creator><creator>Reed, S.I</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19890801</creationdate><title>A family of cyclin homologs that control the G1 phase in yeast</title><author>Hadwiger, J.A. (University of California-San Diego, La Jolla, CA) ; Wittenberg, C ; Richardson, H.E ; Barros Lopes, M. de ; Reed, S.I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-7f24b5622e0bf8753db5db848cdfe5d0626aae32534ac14ddbfa85b7ec9771473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1989</creationdate><topic>ADN</topic><topic>Amino Acid Sequence</topic><topic>Autoantigens - genetics</topic><topic>Biological and medical sciences</topic><topic>Cell cycle</topic><topic>CELL DIVISION</topic><topic>Cell growth</topic><topic>Cells</topic><topic>CODE GENETIQUE</topic><topic>CODIGO GENETICO</topic><topic>Cyclins</topic><topic>DIVISION CELLULAIRE</topic><topic>DIVISION CELULAR</topic><topic>DNA</topic><topic>DNA Transposable Elements</topic><topic>DNA, Fungal - genetics</topic><topic>DNA, Fungal - isolation & purification</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes</topic><topic>Genes, Fungal</topic><topic>Genes. Genome</topic><topic>GENETIC CODE</topic><topic>GENETIC ENGINEERING</topic><topic>Genetic mutation</topic><topic>GENIE GENETIQUE</topic><topic>Haploidy</topic><topic>Humans</topic><topic>INGENIERIA GENETICA</topic><topic>Interphase</topic><topic>LEVADURA</topic><topic>LEVURE</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>MUTACION</topic><topic>MUTATION</topic><topic>Nuclear Proteins - genetics</topic><topic>PEPTIDE</topic><topic>PEPTIDES</topic><topic>PEPTIDOS</topic><topic>Phenotypes</topic><topic>Plasmids</topic><topic>Proliferating Cell Nuclear Antigen</topic><topic>Protein Kinases - genetics</topic><topic>PROTEINAS</topic><topic>PROTEINE</topic><topic>PROTEINS</topic><topic>SACCHAROMYCES CEREVISIAE</topic><topic>Saccharomyces cerevisiae - cytology</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Tripeptidyl-Peptidase 1</topic><topic>YEASTS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hadwiger, J.A. (University of California-San Diego, La Jolla, CA)</creatorcontrib><creatorcontrib>Wittenberg, C</creatorcontrib><creatorcontrib>Richardson, H.E</creatorcontrib><creatorcontrib>Barros Lopes, M. de</creatorcontrib><creatorcontrib>Reed, S.I</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hadwiger, J.A. (University of California-San Diego, La Jolla, CA)</au><au>Wittenberg, C</au><au>Richardson, H.E</au><au>Barros Lopes, M. de</au><au>Reed, S.I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A family of cyclin homologs that control the G1 phase in yeast</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1989-08-01</date><risdate>1989</risdate><volume>86</volume><issue>16</issue><spage>6255</spage><epage>6259</epage><pages>6255-6259</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Two Saccharomyces cerevisiae genes were isolated based upon their dosage-dependent rescue of a temperature-sensitive mutation of the gene CDC28, which encodes a protein kinase involved in control of cell division. CLN1 and CLN2 encode closely related proteins that also share homology with cyclins. Cyclins, characterized by a dramatic periodicity of abundance through the cell cycle, are thought to be involved in mitotic induction in animal cells. A dominant mutation in the CLN2 gene, CLN2-1, advances the G1- to S-phase transition in cycling cells and impairs the ability of cells to arrest in G1 phase in response to external signals, suggesting that the encoded protein is involved in G1 control of the cell cycle in Saccharomyces.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>2569741</pmid><doi>10.1073/pnas.86.16.6255</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1989-08, Vol.86 (16), p.6255-6259 |
| issn | 0027-8424 1091-6490 |
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| source | Jstor Complete Legacy; MEDLINE; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | ADN Amino Acid Sequence Autoantigens - genetics Biological and medical sciences Cell cycle CELL DIVISION Cell growth Cells CODE GENETIQUE CODIGO GENETICO Cyclins DIVISION CELLULAIRE DIVISION CELULAR DNA DNA Transposable Elements DNA, Fungal - genetics DNA, Fungal - isolation & purification Fundamental and applied biological sciences. Psychology Genes Genes, Fungal Genes. Genome GENETIC CODE GENETIC ENGINEERING Genetic mutation GENIE GENETIQUE Haploidy Humans INGENIERIA GENETICA Interphase LEVADURA LEVURE Molecular and cellular biology Molecular genetics Molecular Sequence Data Multigene Family MUTACION MUTATION Nuclear Proteins - genetics PEPTIDE PEPTIDES PEPTIDOS Phenotypes Plasmids Proliferating Cell Nuclear Antigen Protein Kinases - genetics PROTEINAS PROTEINE PROTEINS SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - cytology Saccharomyces cerevisiae - genetics Sequence Homology, Nucleic Acid Tripeptidyl-Peptidase 1 YEASTS |
| title | A family of cyclin homologs that control the G1 phase in yeast |
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