Circulating ICAM-1 levels in serum of uveitis patients
Intercellular Adhesion Molecule-1 (ICAM-1) is a cytokine-inducible adhesion molecule expressed on cells of multiple lineages at sites of inflammation. Recently a truncated form of ICAM-1 has been discovered to be circulating in serum. This study reports on circulating serum (cICAM-1) levels in 132 u...
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| Veröffentlicht in: | Current eye research 1992, Vol.11 (S1), p.161-166 |
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| container_title | Current eye research |
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| creator | Arocker-Mettinger, Elisabeth Steurer-Georgiew, L. Steurer, M. Huber-Spitzy, V. Hoelzl, E. Grabner, G. Kuchar, A. |
| description | Intercellular Adhesion Molecule-1 (ICAM-1) is a cytokine-inducible adhesion molecule expressed on cells of multiple lineages at sites of inflammation. Recently a truncated form of ICAM-1 has been discovered to be circulating in serum. This study reports on circulating serum (cICAM-1) levels in 132 uveitis patients (HLA-B 27 pos. acute anterior uveitis (AAU); HLA-B27 neg. anterior uveitis (AU); intermediate uveitis (IU); heterochromic cyclitis Fuchs (HCF); sarcoidosis; Toxoplasmosis).
Measurement of circulating ICAM-1 serum levels was performed using a monoclonal antibody based ELISA, with healthy blood donors serving as the control group.
Applying multiple variance analysis and the Student Newmann-Keuls test we found a statistically significant elevation of serum cICAM-1 level in the HLA-B 27 neg. AU group (n:31), in the IU group (n:25) and in patients with sarcoidosis (n:18). Serum levels of HLA-B27 pos. AAU patients, patients with HCF and patients suffering from ocular toxoplasmosis did not differ significantly from levels of the control group. |
| doi_str_mv | 10.3109/02713689208999527 |
| format | Article |
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Measurement of circulating ICAM-1 serum levels was performed using a monoclonal antibody based ELISA, with healthy blood donors serving as the control group.
Applying multiple variance analysis and the Student Newmann-Keuls test we found a statistically significant elevation of serum cICAM-1 level in the HLA-B 27 neg. AU group (n:31), in the IU group (n:25) and in patients with sarcoidosis (n:18). Serum levels of HLA-B27 pos. AAU patients, patients with HCF and patients suffering from ocular toxoplasmosis did not differ significantly from levels of the control group.</description><identifier>ISSN: 0271-3683</identifier><identifier>EISSN: 1460-2202</identifier><identifier>DOI: 10.3109/02713689208999527</identifier><identifier>PMID: 1358555</identifier><identifier>CODEN: CEYRDM</identifier><language>eng</language><publisher>Lisse: Informa UK Ltd</publisher><subject>Acute Disease ; Adolescent ; Adult ; Aged ; Antigens, CD - blood ; Biological and medical sciences ; Cell Adhesion Molecules - blood ; Enzyme-Linked Immunosorbent Assay ; Eye Diseases - blood ; Female ; HLA-B27 Antigen - blood ; Humans ; Intercellular Adhesion Molecule-1 ; Iridocyclitis - blood ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Sarcoidosis - blood ; Toxoplasmosis, Ocular - blood ; Uvea diseases ; Uveitis - blood ; Uveitis, Anterior - blood ; Uveitis, Intermediate - blood</subject><ispartof>Current eye research, 1992, Vol.11 (S1), p.161-166</ispartof><rights>1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-64ee965669ffededfcea87a7f2ffa6fb9f7bef2ffc7ce1563de4139de1764c1c3</citedby><cites>FETCH-LOGICAL-c430t-64ee965669ffededfcea87a7f2ffa6fb9f7bef2ffc7ce1563de4139de1764c1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/02713689208999527$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/02713689208999527$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,4024,4050,4051,23930,23931,25140,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5625950$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1358555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arocker-Mettinger, Elisabeth</creatorcontrib><creatorcontrib>Steurer-Georgiew, L.</creatorcontrib><creatorcontrib>Steurer, M.</creatorcontrib><creatorcontrib>Huber-Spitzy, V.</creatorcontrib><creatorcontrib>Hoelzl, E.</creatorcontrib><creatorcontrib>Grabner, G.</creatorcontrib><creatorcontrib>Kuchar, A.</creatorcontrib><title>Circulating ICAM-1 levels in serum of uveitis patients</title><title>Current eye research</title><addtitle>Curr Eye Res</addtitle><description>Intercellular Adhesion Molecule-1 (ICAM-1) is a cytokine-inducible adhesion molecule expressed on cells of multiple lineages at sites of inflammation. Recently a truncated form of ICAM-1 has been discovered to be circulating in serum. This study reports on circulating serum (cICAM-1) levels in 132 uveitis patients (HLA-B 27 pos. acute anterior uveitis (AAU); HLA-B27 neg. anterior uveitis (AU); intermediate uveitis (IU); heterochromic cyclitis Fuchs (HCF); sarcoidosis; Toxoplasmosis).
Measurement of circulating ICAM-1 serum levels was performed using a monoclonal antibody based ELISA, with healthy blood donors serving as the control group.
Applying multiple variance analysis and the Student Newmann-Keuls test we found a statistically significant elevation of serum cICAM-1 level in the HLA-B 27 neg. AU group (n:31), in the IU group (n:25) and in patients with sarcoidosis (n:18). Serum levels of HLA-B27 pos. AAU patients, patients with HCF and patients suffering from ocular toxoplasmosis did not differ significantly from levels of the control group.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antigens, CD - blood</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Eye Diseases - blood</subject><subject>Female</subject><subject>HLA-B27 Antigen - blood</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1</subject><subject>Iridocyclitis - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Sarcoidosis - blood</subject><subject>Toxoplasmosis, Ocular - blood</subject><subject>Uvea diseases</subject><subject>Uveitis - blood</subject><subject>Uveitis, Anterior - blood</subject><subject>Uveitis, Intermediate - blood</subject><issn>0271-3683</issn><issn>1460-2202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kN1LwzAUxYMoc07_AB-EPohv1Xw0aYO-yPALJr7oc8nSG5eRtjNpJ_vvbelURNjTJff8zuHmIHRK8CUjWF5hmhImMklxJqXkNN1DY5IIHFOK6T4a93rcAewQHYWwxLhfJCM0IoxnnPMxElPrdetUY6v36Gl6-xyTyMEaXIhsFQXwbRnVJmrXYBsbolUHQtWEY3RglAtwsp0T9HZ_9zp9jGcvD13KLNYJw00sEgApuBDSGCigMBpUlqrUUGOUMHNp0jn0D51qIFywAhLCZAEkFYkmmk3QxZC78vVHC6HJSxs0OKcqqNuQp4xmGcaiA8kAal-H4MHkK29L5Tc5wXnfVf6vq85ztg1v5yUUv46hnE4_3-oqaOWMV5W24QfjgnLJcYfdDJitTO1L9Vl7V-SN2rjaf3vYriuu_9gXoFyz0MpDvqxbX3X17vjDFzQhlnM</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Arocker-Mettinger, Elisabeth</creator><creator>Steurer-Georgiew, L.</creator><creator>Steurer, M.</creator><creator>Huber-Spitzy, V.</creator><creator>Hoelzl, E.</creator><creator>Grabner, G.</creator><creator>Kuchar, A.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Swets & Zeitlinger</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Circulating ICAM-1 levels in serum of uveitis patients</title><author>Arocker-Mettinger, Elisabeth ; Steurer-Georgiew, L. ; Steurer, M. ; Huber-Spitzy, V. ; Hoelzl, E. ; Grabner, G. ; Kuchar, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-64ee965669ffededfcea87a7f2ffa6fb9f7bef2ffc7ce1563de4139de1764c1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Acute Disease</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antigens, CD - blood</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Eye Diseases - blood</topic><topic>Female</topic><topic>HLA-B27 Antigen - blood</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1</topic><topic>Iridocyclitis - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Sarcoidosis - blood</topic><topic>Toxoplasmosis, Ocular - blood</topic><topic>Uvea diseases</topic><topic>Uveitis - blood</topic><topic>Uveitis, Anterior - blood</topic><topic>Uveitis, Intermediate - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arocker-Mettinger, Elisabeth</creatorcontrib><creatorcontrib>Steurer-Georgiew, L.</creatorcontrib><creatorcontrib>Steurer, M.</creatorcontrib><creatorcontrib>Huber-Spitzy, V.</creatorcontrib><creatorcontrib>Hoelzl, E.</creatorcontrib><creatorcontrib>Grabner, G.</creatorcontrib><creatorcontrib>Kuchar, A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current eye research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arocker-Mettinger, Elisabeth</au><au>Steurer-Georgiew, L.</au><au>Steurer, M.</au><au>Huber-Spitzy, V.</au><au>Hoelzl, E.</au><au>Grabner, G.</au><au>Kuchar, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating ICAM-1 levels in serum of uveitis patients</atitle><jtitle>Current eye research</jtitle><addtitle>Curr Eye Res</addtitle><date>1992</date><risdate>1992</risdate><volume>11</volume><issue>S1</issue><spage>161</spage><epage>166</epage><pages>161-166</pages><issn>0271-3683</issn><eissn>1460-2202</eissn><coden>CEYRDM</coden><abstract>Intercellular Adhesion Molecule-1 (ICAM-1) is a cytokine-inducible adhesion molecule expressed on cells of multiple lineages at sites of inflammation. Recently a truncated form of ICAM-1 has been discovered to be circulating in serum. This study reports on circulating serum (cICAM-1) levels in 132 uveitis patients (HLA-B 27 pos. acute anterior uveitis (AAU); HLA-B27 neg. anterior uveitis (AU); intermediate uveitis (IU); heterochromic cyclitis Fuchs (HCF); sarcoidosis; Toxoplasmosis).
Measurement of circulating ICAM-1 serum levels was performed using a monoclonal antibody based ELISA, with healthy blood donors serving as the control group.
Applying multiple variance analysis and the Student Newmann-Keuls test we found a statistically significant elevation of serum cICAM-1 level in the HLA-B 27 neg. AU group (n:31), in the IU group (n:25) and in patients with sarcoidosis (n:18). Serum levels of HLA-B27 pos. AAU patients, patients with HCF and patients suffering from ocular toxoplasmosis did not differ significantly from levels of the control group.</abstract><cop>Lisse</cop><pub>Informa UK Ltd</pub><pmid>1358555</pmid><doi>10.3109/02713689208999527</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0271-3683 |
| ispartof | Current eye research, 1992, Vol.11 (S1), p.161-166 |
| issn | 0271-3683 1460-2202 |
| language | eng |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN |
| subjects | Acute Disease Adolescent Adult Aged Antigens, CD - blood Biological and medical sciences Cell Adhesion Molecules - blood Enzyme-Linked Immunosorbent Assay Eye Diseases - blood Female HLA-B27 Antigen - blood Humans Intercellular Adhesion Molecule-1 Iridocyclitis - blood Male Medical sciences Middle Aged Ophthalmology Sarcoidosis - blood Toxoplasmosis, Ocular - blood Uvea diseases Uveitis - blood Uveitis, Anterior - blood Uveitis, Intermediate - blood |
| title | Circulating ICAM-1 levels in serum of uveitis patients |
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