Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats
The effects of one-time ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats were investigated. Male Donryu rats that had been fed semi-purified feed were given 5 g/kg ethanol solution (25%, w/v) via a stomach tube and killed 16 h after intubat...
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| Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1992, Vol.56 (4), p.576-579 |
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| creator | Mochizuki, Satoshi Oda, Hiroaki Yoshida, Akira |
| description | The effects of one-time ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats were investigated. Male Donryu rats that had been fed semi-purified feed were given 5 g/kg ethanol solution (25%, w/v) via a stomach tube and killed 16 h after intubation. The amount of ascorbic acid excreted in the urine after ethanol administration increased, but renal and adrenal concentrations of ascorbic acid decreased. The serum levels of total cholesterol, high-density-lipoprotein cholesterol, triglycerides, phospholipids, and non-esterified fatty acids were elevated in rats given ethanol, but hepatic level of total lipids, cholesterol, triglycerides, phospholipids were not. The hepatic concentrations of cytochrome P-450 and cytochrome b
5
did not increase, but this large dose of ethanol increased the activities of aminopyrine N-demethylase and cytochrome c reductase.
These results indicated that the single dose of ethanol affected the ascorbic acid and lipid metabolism of rats, and induced drug-metabolizing enzymes in their liver. |
| doi_str_mv | 10.1271/bbb.56.576 |
| format | Article |
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5
did not increase, but this large dose of ethanol increased the activities of aminopyrine N-demethylase and cytochrome c reductase.
These results indicated that the single dose of ethanol affected the ascorbic acid and lipid metabolism of rats, and induced drug-metabolizing enzymes in their liver.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.56.576</identifier><identifier>PMID: 27280650</identifier><language>eng</language><publisher>Tokyo: Taylor & Francis</publisher><subject>acide ascorbique ; acido ascorbico ; actividad enzimatica ; activite enzymatique ; Alcoholism and acute alcohol poisoning ; ascorbic acid ; Biological and medical sciences ; drugs ; enzymic activity ; etanol ; ethanol ; foie ; higado ; lipid metabolism ; liver ; Medical sciences ; medicament ; medicamentos ; metabolisme des lipides ; metabolismo de lipidos ; rat ; rata ; rats ; Toxicology</subject><ispartof>Bioscience, biotechnology, and biochemistry, 1992, Vol.56 (4), p.576-579</ispartof><rights>Copyright 1992 Taylor and Francis Group LLC 1992</rights><rights>1992 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c578t-8ff55dae4d0c3c073ef8fa25c5263f550b3ea0e0819bae17debd0df23b9b24263</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5623430$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27280650$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mochizuki, Satoshi</creatorcontrib><creatorcontrib>Oda, Hiroaki</creatorcontrib><creatorcontrib>Yoshida, Akira</creatorcontrib><creatorcontrib>Oita Univ. (Japan). Faculty of Education</creatorcontrib><title>Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>The effects of one-time ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats were investigated. Male Donryu rats that had been fed semi-purified feed were given 5 g/kg ethanol solution (25%, w/v) via a stomach tube and killed 16 h after intubation. The amount of ascorbic acid excreted in the urine after ethanol administration increased, but renal and adrenal concentrations of ascorbic acid decreased. The serum levels of total cholesterol, high-density-lipoprotein cholesterol, triglycerides, phospholipids, and non-esterified fatty acids were elevated in rats given ethanol, but hepatic level of total lipids, cholesterol, triglycerides, phospholipids were not. The hepatic concentrations of cytochrome P-450 and cytochrome b
5
did not increase, but this large dose of ethanol increased the activities of aminopyrine N-demethylase and cytochrome c reductase.
These results indicated that the single dose of ethanol affected the ascorbic acid and lipid metabolism of rats, and induced drug-metabolizing enzymes in their liver.</description><subject>acide ascorbique</subject><subject>acido ascorbico</subject><subject>actividad enzimatica</subject><subject>activite enzymatique</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>ascorbic acid</subject><subject>Biological and medical sciences</subject><subject>drugs</subject><subject>enzymic activity</subject><subject>etanol</subject><subject>ethanol</subject><subject>foie</subject><subject>higado</subject><subject>lipid metabolism</subject><subject>liver</subject><subject>Medical sciences</subject><subject>medicament</subject><subject>medicamentos</subject><subject>metabolisme des lipides</subject><subject>metabolismo de lipidos</subject><subject>rat</subject><subject>rata</subject><subject>rats</subject><subject>Toxicology</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNp90UuLFDEQAOAgijuuXvwB0qAHEXrMo5N0H5fFJwsK6jnkUZnN0t0Zk7Q6e_SXm3Fm9uBBCCRUvlQlKYSeErwmVJLXxpg1F2suxT20IqyTrRg6eR-t8EBE23ecnKFHOd9gXAOcPERnVNIeC45X6PeX65hKWyBNDXgPtuQm-gbKtZ7j2IS5xF_B6hLi3NShs43JBNtoG1yjZ9eMYVtXExRt4hjy9DdYpUvLpj2Fb8O8aWC-3U2Qa8566AekfZ2kS36MHng9ZnhynM_Rt7dvvl6-b68-vftweXHVWi770vbec-40dA5bZrFk4HuvKbecCla3sGGgMeCeDEYDkQ6Mw85TZgZDu2rO0ctD3m2K3xfIRU0hWxhHPUNcsiJy4L0QVMhKn_9Db-KS5no7RbpuYAOVPanq1UHZFHNO4NU2hUmnnSJY7TujamcUF6p2puJnx5SLmcDd0VMrKnhxBPWT9eiTnm3Id44Lyjq2Z_zAwuxjmvTPmEanit6NMZ3OsP_V9zoqvUmVffxMhqHDmOH6IvYHLdyzJA</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Mochizuki, Satoshi</creator><creator>Oda, Hiroaki</creator><creator>Yoshida, Akira</creator><general>Taylor & Francis</general><general>Japan Society for Bioscience Biotechnology and Agrochemistry</general><general>Oxford University Press</general><scope>FBQ</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1992</creationdate><title>Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats</title><author>Mochizuki, Satoshi ; Oda, Hiroaki ; Yoshida, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c578t-8ff55dae4d0c3c073ef8fa25c5263f550b3ea0e0819bae17debd0df23b9b24263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>acide ascorbique</topic><topic>acido ascorbico</topic><topic>actividad enzimatica</topic><topic>activite enzymatique</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>ascorbic acid</topic><topic>Biological and medical sciences</topic><topic>drugs</topic><topic>enzymic activity</topic><topic>etanol</topic><topic>ethanol</topic><topic>foie</topic><topic>higado</topic><topic>lipid metabolism</topic><topic>liver</topic><topic>Medical sciences</topic><topic>medicament</topic><topic>medicamentos</topic><topic>metabolisme des lipides</topic><topic>metabolismo de lipidos</topic><topic>rat</topic><topic>rata</topic><topic>rats</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mochizuki, Satoshi</creatorcontrib><creatorcontrib>Oda, Hiroaki</creatorcontrib><creatorcontrib>Yoshida, Akira</creatorcontrib><creatorcontrib>Oita Univ. (Japan). Faculty of Education</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mochizuki, Satoshi</au><au>Oda, Hiroaki</au><au>Yoshida, Akira</au><aucorp>Oita Univ. (Japan). Faculty of Education</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>1992</date><risdate>1992</risdate><volume>56</volume><issue>4</issue><spage>576</spage><epage>579</epage><pages>576-579</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>The effects of one-time ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats were investigated. Male Donryu rats that had been fed semi-purified feed were given 5 g/kg ethanol solution (25%, w/v) via a stomach tube and killed 16 h after intubation. The amount of ascorbic acid excreted in the urine after ethanol administration increased, but renal and adrenal concentrations of ascorbic acid decreased. The serum levels of total cholesterol, high-density-lipoprotein cholesterol, triglycerides, phospholipids, and non-esterified fatty acids were elevated in rats given ethanol, but hepatic level of total lipids, cholesterol, triglycerides, phospholipids were not. The hepatic concentrations of cytochrome P-450 and cytochrome b
5
did not increase, but this large dose of ethanol increased the activities of aminopyrine N-demethylase and cytochrome c reductase.
These results indicated that the single dose of ethanol affected the ascorbic acid and lipid metabolism of rats, and induced drug-metabolizing enzymes in their liver.</abstract><cop>Tokyo</cop><pub>Taylor & Francis</pub><pmid>27280650</pmid><doi>10.1271/bbb.56.576</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0916-8451 |
| ispartof | Bioscience, biotechnology, and biochemistry, 1992, Vol.56 (4), p.576-579 |
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| language | eng |
| recordid | cdi_pascalfrancis_primary_5623430 |
| source | J-STAGE Free; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | acide ascorbique acido ascorbico actividad enzimatica activite enzymatique Alcoholism and acute alcohol poisoning ascorbic acid Biological and medical sciences drugs enzymic activity etanol ethanol foie higado lipid metabolism liver Medical sciences medicament medicamentos metabolisme des lipides metabolismo de lipidos rat rata rats Toxicology |
| title | Short-term effects of ethanol intoxication on ascorbic acid and lipid metabolism and on drug-metabolizing enzymes in liver of rats |
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