Mechanisms of dioxin tumor promotion: Implications for risk assessment

TCDD is a liver carcinogen in female rats but not male rats. In a two stage model for hepatocarcinogenesis, using a single initiating dose of diethylnitrosamine (DEN) and chronic exposure to TCDD (25 ng/kg/day for 30 weeks), ovariectomy prevented the tumor promoting actions of TCDD. This finding was...

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Veröffentlicht in:	Chemosphere (Oxford) 1992, Vol.25 (1), p.177-180
Hauptverfasser:	Lucier, G.W., Clark, G., Tritscher, A., Foley, J., Maronpot, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Medical sciences Tumors
Online-Zugang:	Volltext
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