Effect of sleep deprivation on brain metabolism of depressed patients
OBJECTIVE: Sleep deprivation is a rapid, nonpharmacologic antidepressant intervention that is effective for a subset of depressed patients. The objective of this study was to identify which brain structures' activity differentiates responders from nonresponders and to study how metabolism in th...
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| Veröffentlicht in: | The American journal of psychiatry 1992-04, Vol.149 (4), p.538-543 |
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| container_title | The American journal of psychiatry |
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| creator | WU, JC GILLIN, JC BUCHSBAUM, MS HERSHEY, T JOHNSON, JC BUNNEY, WE |
| description | OBJECTIVE: Sleep deprivation is a rapid, nonpharmacologic antidepressant
intervention that is effective for a subset of depressed patients. The
objective of this study was to identify which brain structures' activity
differentiates responders from nonresponders and to study how metabolism in
these brain regions changes with mood. METHOD: Regional cerebral glucose
metabolism was assessed by positron emission tomography (PET) with
[18F]deoxyglucose (FDG) before and after total sleep deprivation in 15
unmedicated awake patients with unipolar major depression and 15 normal
control subjects, who did the continuous performance test during FDG
uptake. RESULTS: After sleep deprivation, four patients showed a 40% or
more improvement on the Hamilton Rating Scale for Depression. Before sleep
deprivation the depressed responders had a significantly higher cingulate
cortex metabolic rate than the depressed nonresponders, and this normalized
after sleep deprivation. The normal control subjects and nonresponding
depressed patients showed no change in cingulate metabolic rate after sleep
deprivation. CONCLUSIONS: Overactivation of the limbic system as assessed
by PET scans may characterize a subset of depressed patients. Normalization
of activity with sleep deprivation is associated with a decrease in
depression. |
| doi_str_mv | 10.1176/ajp.149.4.538 |
| format | Article |
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intervention that is effective for a subset of depressed patients. The
objective of this study was to identify which brain structures' activity
differentiates responders from nonresponders and to study how metabolism in
these brain regions changes with mood. METHOD: Regional cerebral glucose
metabolism was assessed by positron emission tomography (PET) with
[18F]deoxyglucose (FDG) before and after total sleep deprivation in 15
unmedicated awake patients with unipolar major depression and 15 normal
control subjects, who did the continuous performance test during FDG
uptake. RESULTS: After sleep deprivation, four patients showed a 40% or
more improvement on the Hamilton Rating Scale for Depression. Before sleep
deprivation the depressed responders had a significantly higher cingulate
cortex metabolic rate than the depressed nonresponders, and this normalized
after sleep deprivation. The normal control subjects and nonresponding
depressed patients showed no change in cingulate metabolic rate after sleep
deprivation. CONCLUSIONS: Overactivation of the limbic system as assessed
by PET scans may characterize a subset of depressed patients. Normalization
of activity with sleep deprivation is associated with a decrease in
depression.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.149.4.538</identifier><identifier>PMID: 1554042</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>WASHINGTON: American Psychiatric Publishing</publisher><subject>Adult ; Affect - physiology ; Biological and medical sciences ; Brain ; Brain - diagnostic imaging ; Brain - metabolism ; Brain - physiology ; Deoxyglucose - analogs & derivatives ; Depressive Disorder - diagnosis ; Depressive Disorder - metabolism ; Depressive Disorder - therapy ; Female ; Fluorodeoxyglucose F18 ; Glucose - metabolism ; Humans ; Life Sciences & Biomedicine ; Limbic System - diagnostic imaging ; Limbic System - metabolism ; Male ; Medical research ; Medical sciences ; Mental depression ; Metabolism ; Miscellaneous ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Science & Technology ; Sleep ; Sleep Deprivation ; Tomography, Emission-Computed ; Treatments</subject><ispartof>The American journal of psychiatry, 1992-04, Vol.149 (4), p.538-543</ispartof><rights>1992 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Apr 1992</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>236</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HL73200017</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-a407t-5d962be1a9ea9f13a2c78f641517587610e1367f62b9157755997a409a06a5e73</citedby><cites>FETCH-LOGICAL-a407t-5d962be1a9ea9f13a2c78f641517587610e1367f62b9157755997a409a06a5e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.149.4.538$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.149.4.538$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>310,311,315,781,785,790,791,2860,21634,23935,23936,25145,27197,27874,27929,27930,77796,77797</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5561927$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1554042$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WU, JC</creatorcontrib><creatorcontrib>GILLIN, JC</creatorcontrib><creatorcontrib>BUCHSBAUM, MS</creatorcontrib><creatorcontrib>HERSHEY, T</creatorcontrib><creatorcontrib>JOHNSON, JC</creatorcontrib><creatorcontrib>BUNNEY, WE</creatorcontrib><title>Effect of sleep deprivation on brain metabolism of depressed patients</title><title>The American journal of psychiatry</title><addtitle>AM J PSYCHIAT</addtitle><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: Sleep deprivation is a rapid, nonpharmacologic antidepressant
intervention that is effective for a subset of depressed patients. The
objective of this study was to identify which brain structures' activity
differentiates responders from nonresponders and to study how metabolism in
these brain regions changes with mood. METHOD: Regional cerebral glucose
metabolism was assessed by positron emission tomography (PET) with
[18F]deoxyglucose (FDG) before and after total sleep deprivation in 15
unmedicated awake patients with unipolar major depression and 15 normal
control subjects, who did the continuous performance test during FDG
uptake. RESULTS: After sleep deprivation, four patients showed a 40% or
more improvement on the Hamilton Rating Scale for Depression. Before sleep
deprivation the depressed responders had a significantly higher cingulate
cortex metabolic rate than the depressed nonresponders, and this normalized
after sleep deprivation. The normal control subjects and nonresponding
depressed patients showed no change in cingulate metabolic rate after sleep
deprivation. CONCLUSIONS: Overactivation of the limbic system as assessed
by PET scans may characterize a subset of depressed patients. Normalization
of activity with sleep deprivation is associated with a decrease in
depression.</description><subject>Adult</subject><subject>Affect - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Brain - physiology</subject><subject>Deoxyglucose - analogs & derivatives</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - metabolism</subject><subject>Depressive Disorder - therapy</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Life Sciences & Biomedicine</subject><subject>Limbic System - diagnostic imaging</subject><subject>Limbic System - metabolism</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Metabolism</subject><subject>Miscellaneous</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Science & Technology</subject><subject>Sleep</subject><subject>Sleep Deprivation</subject><subject>Tomography, Emission-Computed</subject><subject>Treatments</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>HZZMR</sourceid><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNqN0cGL1DAUBvAgyjquHj0KRRcPSse8pEma4zKMrjDgRcFbSDsv0KFtatOu-N_7uh1WEQWhUEp-75F-H2PPgW8BjH7nT8MWCrsttkqWD9gGlFS5EaJ8yDacc5FbJb8-Zk9SOtEnl0ZcsAtQquCF2LD9PgSspyyGLLWIQ3bEYWxu_dTEPqOnGn3TZx1Ovoptk7oFLgRTwmM2kMN-Sk_Zo-DbhM_O70v25f3-8-4mP3z68HF3fch9wc2Uq6PVokLwFr0NIL2oTRl0AQqMKo0GjiC1CYQsKGOUstbQqPVce4VGXrLX695hjN9mTJPrmlRj2_oe45ycEaXWwnKCL_-ApziPPd3NCcEVLwVftr36FwIJXHNOKZHKV1WPMaURg6OAOj_-cMDd0oCjBhw14ApHDZB_cd46Vx0ef-k1cjq_Op_7VPs2jL6vm3TPlNJgxXK5cmXfsYoh1ZRzjffqGqwVNwcjBVUKZtdMd43t4txPNPr2_0dJv1m1H4bmtwT--nM_AT-7udI</recordid><startdate>19920401</startdate><enddate>19920401</enddate><creator>WU, JC</creator><creator>GILLIN, JC</creator><creator>BUCHSBAUM, MS</creator><creator>HERSHEY, T</creator><creator>JOHNSON, JC</creator><creator>BUNNEY, WE</creator><general>American Psychiatric Publishing</general><general>Amer Psychiatric Publishing, Inc</general><general>American Psychiatric Association</general><scope>17B</scope><scope>BLEPL</scope><scope>DTL</scope><scope>DVR</scope><scope>EGQ</scope><scope>EZCTM</scope><scope>HZZMR</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19920401</creationdate><title>Effect of sleep deprivation on brain metabolism of depressed patients</title><author>WU, JC ; GILLIN, JC ; BUCHSBAUM, MS ; HERSHEY, T ; JOHNSON, JC ; BUNNEY, WE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a407t-5d962be1a9ea9f13a2c78f641517587610e1367f62b9157755997a409a06a5e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Affect - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Brain - physiology</topic><topic>Deoxyglucose - analogs & derivatives</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - metabolism</topic><topic>Depressive Disorder - therapy</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Life Sciences & Biomedicine</topic><topic>Limbic System - diagnostic imaging</topic><topic>Limbic System - metabolism</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Metabolism</topic><topic>Miscellaneous</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychology. 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intervention that is effective for a subset of depressed patients. The
objective of this study was to identify which brain structures' activity
differentiates responders from nonresponders and to study how metabolism in
these brain regions changes with mood. METHOD: Regional cerebral glucose
metabolism was assessed by positron emission tomography (PET) with
[18F]deoxyglucose (FDG) before and after total sleep deprivation in 15
unmedicated awake patients with unipolar major depression and 15 normal
control subjects, who did the continuous performance test during FDG
uptake. RESULTS: After sleep deprivation, four patients showed a 40% or
more improvement on the Hamilton Rating Scale for Depression. Before sleep
deprivation the depressed responders had a significantly higher cingulate
cortex metabolic rate than the depressed nonresponders, and this normalized
after sleep deprivation. The normal control subjects and nonresponding
depressed patients showed no change in cingulate metabolic rate after sleep
deprivation. CONCLUSIONS: Overactivation of the limbic system as assessed
by PET scans may characterize a subset of depressed patients. Normalization
of activity with sleep deprivation is associated with a decrease in
depression.</abstract><cop>WASHINGTON</cop><pub>American Psychiatric Publishing</pub><pmid>1554042</pmid><doi>10.1176/ajp.149.4.538</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | The American journal of psychiatry, 1992-04, Vol.149 (4), p.538-543 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_5561927 |
| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Affect - physiology Biological and medical sciences Brain Brain - diagnostic imaging Brain - metabolism Brain - physiology Deoxyglucose - analogs & derivatives Depressive Disorder - diagnosis Depressive Disorder - metabolism Depressive Disorder - therapy Female Fluorodeoxyglucose F18 Glucose - metabolism Humans Life Sciences & Biomedicine Limbic System - diagnostic imaging Limbic System - metabolism Male Medical research Medical sciences Mental depression Metabolism Miscellaneous Psychiatric Status Rating Scales Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Science & Technology Sleep Sleep Deprivation Tomography, Emission-Computed Treatments |
| title | Effect of sleep deprivation on brain metabolism of depressed patients |
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