Active Nuclear Import of Human Immunodeficiency Virus Type 1 Preintegration Complexes

After cell infection by the human immunodeficiency virus type 1 (HIV-1), nascent viral DNA in the form of a high molecular weight nucleoprotein preintegration complex must be transported to the nucleus of the host cell prior to integration of viral DNA with the host genome. The mechanism used by ret...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-07, Vol.89 (14), p.6580-6584
Hauptverfasser:	Bukrinsky, Michael I., Sharova, Natalia, Dempsey, Michael P., Stanwick, Trevor L., Bukrinskaya, Alice G., Haggerty, Sheryl, Stevenson, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism AIDS/HIV Biochemistry Biological and medical sciences Biological Transport, Active Cell Cycle Cell nucleus Cell Nucleus - metabolism Cells, Cultured Cellular metabolism Circles Cytoplasm - metabolism DNA DNA Nucleotidyltransferases - metabolism DNA, Viral - analysis DNA, Viral - metabolism Fundamental and applied biological sciences. Psychology HIV HIV 1 HIV Infections - microbiology HIV-1 - genetics HIV-1 - growth & development Human immunodeficiency virus In Vitro Techniques Infections Integrases Medical research Microbiology Polymerase chain reaction Proviruses - metabolism Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains T lymphocytes T-Lymphocytes - cytology T-Lymphocytes - microbiology Viral DNA Virology Virus Integration Virus Replication Viruses
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