T-Cell receptor variable (V) gene usage by lymphoid populations in T-cell lymphoma
A panel of monoclonal antibodies specific for TcR V gene families was used to study TcR V region expression in 28 cases of malignant and reactive T‐cell expansions including four cases of mixed cellularity Hodgkin's disease (HD) and five reactive cases. TcR Vβ5 gene products were represented in...
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| Veröffentlicht in: | The Journal of pathology 1992-02, Vol.166 (2), p.109-112 |
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| container_title | The Journal of pathology |
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| creator | Smith, John L. Lane, Andrew C. Hodges, Elizabeth Reynolds, Wendy M. Howell, William M. Jones, David B. Janson, Carl H. |
| description | A panel of monoclonal antibodies specific for TcR V gene families was used to study TcR V region expression in 28 cases of malignant and reactive T‐cell expansions including four cases of mixed cellularity Hodgkin's disease (HD) and five reactive cases. TcR Vβ5 gene products were represented in three cases of lymphoblastic malignancy (Vβ5.1, Vβ5.2) and two cases of peripheral T‐cell lymphoma (PTCL) (Vβ5.1). In the PTCL cases, the expanded family was found in the absence of clonal TcR gene rearrangements and in one of these cases with Ig JH and Ck clonal gene rearrangements consistent with the presence of a phenotypically and histologically undetectable clonal B‐cell population. In a third PTCL case not investigated for genotype, the TCR Va12 family was overrepresented. Expanded TcR Va2 and Vβ5.1 families were identified in HD and Vβ8 and Vβ5.2/Vβ5.3 families in a reactive lymph node and CD3 and CD8‐positive blood lymphocytosis respectively. Further study of PTCL and related entities are needed to establish whether expanded TcR families are common in those cases that fail to exhibit clonal TcR gene rearrangement. |
| doi_str_mv | 10.1002/path.1711660205 |
| format | Article |
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TcR Vβ5 gene products were represented in three cases of lymphoblastic malignancy (Vβ5.1, Vβ5.2) and two cases of peripheral T‐cell lymphoma (PTCL) (Vβ5.1). In the PTCL cases, the expanded family was found in the absence of clonal TcR gene rearrangements and in one of these cases with Ig JH and Ck clonal gene rearrangements consistent with the presence of a phenotypically and histologically undetectable clonal B‐cell population. In a third PTCL case not investigated for genotype, the TCR Va12 family was overrepresented. Expanded TcR Va2 and Vβ5.1 families were identified in HD and Vβ8 and Vβ5.2/Vβ5.3 families in a reactive lymph node and CD3 and CD8‐positive blood lymphocytosis respectively. Further study of PTCL and related entities are needed to establish whether expanded TcR families are common in those cases that fail to exhibit clonal TcR gene rearrangement.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1711660205</identifier><identifier>PMID: 1560311</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Antibodies, Monoclonal ; ariable gene ; Biological and medical sciences ; Gene Expression - genetics ; Gene Rearrangement, T-Lymphocyte - genetics ; Genotype ; Hematologic and hematopoietic diseases ; Humans ; Immunohistochemistry ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Life Sciences & Biomedicine ; Lymphoma, T-Cell, Cutaneous - genetics ; Medical sciences ; Oncology ; Pathology ; Phenotype ; Receptors, Antigen, T-Cell - genetics ; Science & Technology ; T-cell lymphomas ; T-cell receptor ; T-Lymphocytes - physiology</subject><ispartof>The Journal of pathology, 1992-02, Vol.166 (2), p.109-112</ispartof><rights>Copyright © 1992 John Wiley & Sons, Ltd.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>13</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992HG61900004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c4425-cfa2b11d91e14306ce56581a60e63939dfb96c6a5482d8113517363ce51621df3</citedby><cites>FETCH-LOGICAL-c4425-cfa2b11d91e14306ce56581a60e63939dfb96c6a5482d8113517363ce51621df3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1711660205$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1711660205$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27197,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5326399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1560311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, John L.</creatorcontrib><creatorcontrib>Lane, Andrew C.</creatorcontrib><creatorcontrib>Hodges, Elizabeth</creatorcontrib><creatorcontrib>Reynolds, Wendy M.</creatorcontrib><creatorcontrib>Howell, William M.</creatorcontrib><creatorcontrib>Jones, David B.</creatorcontrib><creatorcontrib>Janson, Carl H.</creatorcontrib><title>T-Cell receptor variable (V) gene usage by lymphoid populations in T-cell lymphoma</title><title>The Journal of pathology</title><addtitle>J PATHOL</addtitle><addtitle>J. Pathol</addtitle><description>A panel of monoclonal antibodies specific for TcR V gene families was used to study TcR V region expression in 28 cases of malignant and reactive T‐cell expansions including four cases of mixed cellularity Hodgkin's disease (HD) and five reactive cases. TcR Vβ5 gene products were represented in three cases of lymphoblastic malignancy (Vβ5.1, Vβ5.2) and two cases of peripheral T‐cell lymphoma (PTCL) (Vβ5.1). In the PTCL cases, the expanded family was found in the absence of clonal TcR gene rearrangements and in one of these cases with Ig JH and Ck clonal gene rearrangements consistent with the presence of a phenotypically and histologically undetectable clonal B‐cell population. In a third PTCL case not investigated for genotype, the TCR Va12 family was overrepresented. Expanded TcR Va2 and Vβ5.1 families were identified in HD and Vβ8 and Vβ5.2/Vβ5.3 families in a reactive lymph node and CD3 and CD8‐positive blood lymphocytosis respectively. Further study of PTCL and related entities are needed to establish whether expanded TcR families are common in those cases that fail to exhibit clonal TcR gene rearrangement.</description><subject>Antibodies, Monoclonal</subject><subject>ariable gene</subject><subject>Biological and medical sciences</subject><subject>Gene Expression - genetics</subject><subject>Gene Rearrangement, T-Lymphocyte - genetics</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Life Sciences & Biomedicine</subject><subject>Lymphoma, T-Cell, Cutaneous - genetics</subject><subject>Medical sciences</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Phenotype</subject><subject>Receptors, Antigen, T-Cell - genetics</subject><subject>Science & Technology</subject><subject>T-cell lymphomas</subject><subject>T-cell receptor</subject><subject>T-Lymphocytes - physiology</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EZCTM</sourceid><sourceid>EIF</sourceid><recordid>eNqNkc-L1DAcxYMo67h69iTkIKJId_NNmrRhT0PRGWHxF6OCl5Cm6W60v0xadf57UzvM4mk95fA-75H3vgg9BnIGhNDzQY_XZ5ABCEEo4XfQCogUicyluItWkaAJSyG7jx6E8I0QIiXnJ-gEuCAMYIU-7pLCNg321thh7D3-qb3TZWPx888v8JXtLJ6CvrK43ONm3w7Xvavw0A9To0fXdwG7Du8SM0cscqsfonu1boJ9dHhP0afXr3bFNrl8t3lTrC8Tk6aUJ6bWtASoJFhIGRHGcsFz0IJYwSSTVV1KYYTmaU6rHIBxyJhgEQNBoarZKXq25A6-_zHZMKrWhfknurP9FFRG85zwmH0bCAIYY5xE8HwBje9D8LZWg3et9nsFRM1zq3ludTN3dDw5RE9la6sbftk36k8Pug5GN7XXnXHhiHFGY1cZsZcL9suWfR2Ms52xR2oNUtLtRoCMByRzn_z_6cKNfy9V9FM3RuvFweoau7-tnnq_3m3_aZssbhdG-_vo1v67EhnLuPrydqMy8hUglbn6wP4ALh3HRQ</recordid><startdate>199202</startdate><enddate>199202</enddate><creator>Smith, John L.</creator><creator>Lane, Andrew C.</creator><creator>Hodges, Elizabeth</creator><creator>Reynolds, Wendy M.</creator><creator>Howell, William M.</creator><creator>Jones, David B.</creator><creator>Janson, Carl H.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>BLEPL</scope><scope>DTL</scope><scope>EZCTM</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>199202</creationdate><title>T-Cell receptor variable (V) gene usage by lymphoid populations in T-cell lymphoma</title><author>Smith, John L. ; Lane, Andrew C. ; Hodges, Elizabeth ; Reynolds, Wendy M. ; Howell, William M. ; Jones, David B. ; Janson, Carl H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4425-cfa2b11d91e14306ce56581a60e63939dfb96c6a5482d8113517363ce51621df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Antibodies, Monoclonal</topic><topic>ariable gene</topic><topic>Biological and medical sciences</topic><topic>Gene Expression - genetics</topic><topic>Gene Rearrangement, T-Lymphocyte - genetics</topic><topic>Genotype</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Life Sciences & Biomedicine</topic><topic>Lymphoma, T-Cell, Cutaneous - genetics</topic><topic>Medical sciences</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Phenotype</topic><topic>Receptors, Antigen, T-Cell - genetics</topic><topic>Science & Technology</topic><topic>T-cell lymphomas</topic><topic>T-cell receptor</topic><topic>T-Lymphocytes - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, John L.</creatorcontrib><creatorcontrib>Lane, Andrew C.</creatorcontrib><creatorcontrib>Hodges, Elizabeth</creatorcontrib><creatorcontrib>Reynolds, Wendy M.</creatorcontrib><creatorcontrib>Howell, William M.</creatorcontrib><creatorcontrib>Jones, David B.</creatorcontrib><creatorcontrib>Janson, Carl H.</creatorcontrib><collection>Istex</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, John L.</au><au>Lane, Andrew C.</au><au>Hodges, Elizabeth</au><au>Reynolds, Wendy M.</au><au>Howell, William M.</au><au>Jones, David B.</au><au>Janson, Carl H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T-Cell receptor variable (V) gene usage by lymphoid populations in T-cell lymphoma</atitle><jtitle>The Journal of pathology</jtitle><stitle>J PATHOL</stitle><addtitle>J. Pathol</addtitle><date>1992-02</date><risdate>1992</risdate><volume>166</volume><issue>2</issue><spage>109</spage><epage>112</epage><pages>109-112</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>A panel of monoclonal antibodies specific for TcR V gene families was used to study TcR V region expression in 28 cases of malignant and reactive T‐cell expansions including four cases of mixed cellularity Hodgkin's disease (HD) and five reactive cases. TcR Vβ5 gene products were represented in three cases of lymphoblastic malignancy (Vβ5.1, Vβ5.2) and two cases of peripheral T‐cell lymphoma (PTCL) (Vβ5.1). In the PTCL cases, the expanded family was found in the absence of clonal TcR gene rearrangements and in one of these cases with Ig JH and Ck clonal gene rearrangements consistent with the presence of a phenotypically and histologically undetectable clonal B‐cell population. In a third PTCL case not investigated for genotype, the TCR Va12 family was overrepresented. Expanded TcR Va2 and Vβ5.1 families were identified in HD and Vβ8 and Vβ5.2/Vβ5.3 families in a reactive lymph node and CD3 and CD8‐positive blood lymphocytosis respectively. Further study of PTCL and related entities are needed to establish whether expanded TcR families are common in those cases that fail to exhibit clonal TcR gene rearrangement.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>1560311</pmid><doi>10.1002/path.1711660205</doi><tpages>4</tpages></addata></record> |
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| subjects | Antibodies, Monoclonal ariable gene Biological and medical sciences Gene Expression - genetics Gene Rearrangement, T-Lymphocyte - genetics Genotype Hematologic and hematopoietic diseases Humans Immunohistochemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Life Sciences & Biomedicine Lymphoma, T-Cell, Cutaneous - genetics Medical sciences Oncology Pathology Phenotype Receptors, Antigen, T-Cell - genetics Science & Technology T-cell lymphomas T-cell receptor T-Lymphocytes - physiology |
| title | T-Cell receptor variable (V) gene usage by lymphoid populations in T-cell lymphoma |
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