Disposition of bepridil in laboratory animals and man

1. The disposition and pharmacokinetics of bepridil (Bp) were studied in mouse, rat, rabbit, rhesus monkey, and man. Bp was essentially completely absorbed by all species. 2. Maximum plasma Bp concentrations were achieved within 2 h of drug administration. Linear but non-proportional, dose-related i...

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Veröffentlicht in:	Xenobiotica 1992, Vol.22 (2), p.153-169
Hauptverfasser:	Wu, W. N., Pritchard, J. F., Ng, K. T., Hills, J. F., Uetz, J. A., Yorgey, K. A., McKown, L. A., O'neill, P. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Animals Antianginal agents. Coronary vasodilator agents Bepridil - pharmacokinetics Biological and medical sciences Cardiovascular system Female Humans Macaca mulatta Male Medical sciences Mice Mice, Inbred Strains Middle Aged Pharmacology. Drug treatments Rabbits Rats Rats, Inbred Strains Species Specificity
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