P300 in multiple sclerosis: a preliminary report

The P300 component of the event-related brain potential (ERP) elicited with auditory stimuli and pattern-shift visual evoked potentials (VEPs) was obtained from 16 patients with multiple sclerosis (MS) and 16 matched control subjects. P300 latency was significantly longer and component amplitude rel...

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Veröffentlicht in:	International journal of psychophysiology 1992-03, Vol.12 (2), p.155-163
Hauptverfasser:	Polich, John, Romine, John S., Sipe, Jack C., Aung, Maung, Dalessio, Donald J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Electroencephalography Evoked Potentials, Auditory - physiology Evoked Potentials, Visual - physiology Female Humans Life Sciences & Biomedicine Male Medical sciences Middle Aged Multiple sclerosis Multiple Sclerosis - physiopathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Neurosciences Neurosciences & Neurology P300 Physiology Psychology Psychology, Biological Psychology, Experimental Science & Technology Social Sciences Visual evoked potential
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Zusammenfassung:	The P300 component of the event-related brain potential (ERP) elicited with auditory stimuli and pattern-shift visual evoked potentials (VEPs) was obtained from 16 patients with multiple sclerosis (MS) and 16 matched control subjects. P300 latency was significantly longer and component amplitude relatively depressed in the MS patients compared to control subjects. The P100 potential of the VEP also was delayed for both full-field and half-field stimulus conditions in the patients compared to control subjects. The findings suggest that the P300 ERP may reflect the cognitive decline associated with MS.
ISSN:	0167-8760 1872-7697
DOI:	10.1016/0167-8760(92)90006-W