Quantitation of fluoxetine hydrochloride in capsules using high-performance liquid chromatography
Abstract A stability-indicating high-performance liquid chromatographic method for the quantitation of fluoxetine hydrochloride in capsules (the only dosage form available) has been developed. The method is accurate and precise with a percent relative standard deviation of 1.04 based on 6 readings....
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| Veröffentlicht in: | Drug development and industrial pharmacy 1992, Vol.18 (2), p.257-264 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Pramar, Yashoda Gupta, V. Das Bethea, Charlie |
| description | Abstract
A stability-indicating high-performance liquid chromatographic method for the quantitation of fluoxetine hydrochloride in capsules (the only dosage form available) has been developed. The method is accurate and precise with a percent relative standard deviation of 1.04 based on 6 readings. An excellent separation of fluoxetine from methyltestosterone (the internal standard) was achieved, and sharp peaks were obtained by adding acetic acid to the mobile phase. The inactive ingredients present in the capsule powder did not interfere with the assay procedure. The recovery of fluoxetine from the synthetic mixtures was quantitative. The drug appears to be very stable in the acidic medium and highly susceptible to degradation in the basic medium. |
| doi_str_mv | 10.3109/03639049209043698 |
| format | Article |
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A stability-indicating high-performance liquid chromatographic method for the quantitation of fluoxetine hydrochloride in capsules (the only dosage form available) has been developed. The method is accurate and precise with a percent relative standard deviation of 1.04 based on 6 readings. An excellent separation of fluoxetine from methyltestosterone (the internal standard) was achieved, and sharp peaks were obtained by adding acetic acid to the mobile phase. The inactive ingredients present in the capsule powder did not interfere with the assay procedure. The recovery of fluoxetine from the synthetic mixtures was quantitative. The drug appears to be very stable in the acidic medium and highly susceptible to degradation in the basic medium.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.3109/03639049209043698</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Analysis ; Biological and medical sciences ; General pharmacology ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Drug development and industrial pharmacy, 1992, Vol.18 (2), p.257-264</ispartof><rights>1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-dd46abc6acbbacf8c633add55b737a5e70c136e5274067c0fb863b5249f9b03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/03639049209043698$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/03639049209043698$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,4010,27900,27901,27902,59620,59726,60409,60515,61194,61229,61375,61410</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5122131$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Pramar, Yashoda</creatorcontrib><creatorcontrib>Gupta, V. Das</creatorcontrib><creatorcontrib>Bethea, Charlie</creatorcontrib><title>Quantitation of fluoxetine hydrochloride in capsules using high-performance liquid chromatography</title><title>Drug development and industrial pharmacy</title><description>Abstract
A stability-indicating high-performance liquid chromatographic method for the quantitation of fluoxetine hydrochloride in capsules (the only dosage form available) has been developed. The method is accurate and precise with a percent relative standard deviation of 1.04 based on 6 readings. An excellent separation of fluoxetine from methyltestosterone (the internal standard) was achieved, and sharp peaks were obtained by adding acetic acid to the mobile phase. The inactive ingredients present in the capsule powder did not interfere with the assay procedure. The recovery of fluoxetine from the synthetic mixtures was quantitative. The drug appears to be very stable in the acidic medium and highly susceptible to degradation in the basic medium.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouH78AG85eK0mzSbdohdZ_IIFEb2XaT42WbJNTVq0_96uq4IIe5k5zPvMzPsidEbJBaOkvCRMsJJMy5yMlYlytocmlOck44XI99FkM8_GET9ERymtCKF5yfkEwXMPTec66FxocDDY-D586M41GttBxSCtD9EpjV2DJbSp9zrhPrlmia1b2qzV0YS4hkZq7N1b7xSWNoY1dGEZobXDCTow4JM-_e7H6OXu9nX-kC2e7h_nN4tMsqLoMqWmAmopQNY1SDOTgjFQivO6YAVwXRBJmdA8L6ZEFJKYeiZYzfNpacqasGNEt1tlDClFbao2ujXEoaKk2iRU_UtoZM63TAtJgjdxNOHSL8hpnlNGR9n1VuaaL6fvIXpVdTCMwfwwbNeVqz-41eA7KyHqahX62IyZ7PjxE-iUjkw</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Pramar, Yashoda</creator><creator>Gupta, V. Das</creator><creator>Bethea, Charlie</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1992</creationdate><title>Quantitation of fluoxetine hydrochloride in capsules using high-performance liquid chromatography</title><author>Pramar, Yashoda ; Gupta, V. Das ; Bethea, Charlie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-dd46abc6acbbacf8c633add55b737a5e70c136e5274067c0fb863b5249f9b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pramar, Yashoda</creatorcontrib><creatorcontrib>Gupta, V. Das</creatorcontrib><creatorcontrib>Bethea, Charlie</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pramar, Yashoda</au><au>Gupta, V. Das</au><au>Bethea, Charlie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitation of fluoxetine hydrochloride in capsules using high-performance liquid chromatography</atitle><jtitle>Drug development and industrial pharmacy</jtitle><date>1992</date><risdate>1992</risdate><volume>18</volume><issue>2</issue><spage>257</spage><epage>264</epage><pages>257-264</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Abstract
A stability-indicating high-performance liquid chromatographic method for the quantitation of fluoxetine hydrochloride in capsules (the only dosage form available) has been developed. The method is accurate and precise with a percent relative standard deviation of 1.04 based on 6 readings. An excellent separation of fluoxetine from methyltestosterone (the internal standard) was achieved, and sharp peaks were obtained by adding acetic acid to the mobile phase. The inactive ingredients present in the capsule powder did not interfere with the assay procedure. The recovery of fluoxetine from the synthetic mixtures was quantitative. The drug appears to be very stable in the acidic medium and highly susceptible to degradation in the basic medium.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><doi>10.3109/03639049209043698</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0363-9045 |
| ispartof | Drug development and industrial pharmacy, 1992, Vol.18 (2), p.257-264 |
| issn | 0363-9045 1520-5762 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_5122131 |
| source | Taylor & Francis; Taylor & Francis Medical Library - CRKN |
| subjects | Analysis Biological and medical sciences General pharmacology Medical sciences Pharmacology. Drug treatments |
| title | Quantitation of fluoxetine hydrochloride in capsules using high-performance liquid chromatography |
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