Effects of 4-Hydroxynonenal, A Product of Lipid Peroxidation, on Cell Proliferation and Ornithine Decarboxylase Activity

4-hydroxynonenal (HNE) is one of the major breakdown products of cellular lipid peroxidation. Its effects on proliferation, ornithine decarboxylase (ODC) activity and DNA synthesis have been investigated in leukemic cell lines. The cells were incubated for 1 hour with different aldehyde concentratio...

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Veröffentlicht in:	Free radical research 1991, Vol.14 (2), p.81-89
Hauptverfasser:	Barrera, Giuseppina, Brossa, Olga, Fazio, Vito Michele, Farace, Maria Giulia, Paradisi, Luciana, Gravela, Enrico, Dianzani, Mario Umberto
Format:	Artikel
Sprache:	eng
Schlagworte:	4-hydroxynonenal Aldehydes - pharmacology Biological and medical sciences Cell cycle, cell proliferation Cell Division - drug effects Cell physiology DNA synthesis DNA, Neoplasm - biosynthesis Fundamental and applied biological sciences. Psychology Humans leukemic cells Lipid Peroxidation Molecular and cellular biology ornithine decarboxylase Ornithine Decarboxylase - metabolism Tumor Cells, Cultured - drug effects
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