Evaluation of modified rice starch, a new excipient for direct compression
Abstract The compression characteristics of modified rice starch (PrimotabRET), a new excipient for the preparation of tablets by direct compression is evaluated. Modified rice starch is an agglomerated rice starch product. It has excellent flowing and disintegration properties. In contrast to other...
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| Veröffentlicht in: | Drug development and industrial pharmacy 1992, Vol.18 (1), p.93-106 |
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| container_title | Drug development and industrial pharmacy |
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| creator | Bos, C. E. Bolhuis, G. K. Lerk, C. F. Duineveld, C. A.A. |
| description | Abstract
The compression characteristics of modified rice starch (PrimotabRET), a new excipient for the preparation of tablets by direct compression is evaluated. Modified rice starch is an agglomerated rice starch product. It has excellent flowing and disintegration properties. In contrast to other starch-based filler-binders, after mixing with a lubricant, the binding properties were sufficient.
Tablets containing oxazepam as a model drug were prepared with modified rice starch as unique filler-binder or with a blend of equal parts of modified rice starch and a commonly used filler-binder. The tablet properties show that modified rice starch is a useful product for the preparation of tablets by direct compression. It can be used as a unique filler-binder, or in combination with other excipients such as α-lactose monohydrate or anhydrous lactose. Combinations with microcrystalline cellulose should be avoided because of the poor flowability of the blends and the slow disintegration of the tablets. |
| doi_str_mv | 10.3109/03639049209043686 |
| format | Article |
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The compression characteristics of modified rice starch (PrimotabRET), a new excipient for the preparation of tablets by direct compression is evaluated. Modified rice starch is an agglomerated rice starch product. It has excellent flowing and disintegration properties. In contrast to other starch-based filler-binders, after mixing with a lubricant, the binding properties were sufficient.
Tablets containing oxazepam as a model drug were prepared with modified rice starch as unique filler-binder or with a blend of equal parts of modified rice starch and a commonly used filler-binder. The tablet properties show that modified rice starch is a useful product for the preparation of tablets by direct compression. It can be used as a unique filler-binder, or in combination with other excipients such as α-lactose monohydrate or anhydrous lactose. Combinations with microcrystalline cellulose should be avoided because of the poor flowability of the blends and the slow disintegration of the tablets.</description><identifier>ISSN: 0363-9045</identifier><identifier>EISSN: 1520-5762</identifier><identifier>DOI: 10.3109/03639049209043686</identifier><language>eng</language><publisher>Colchester: Informa UK Ltd</publisher><subject>Biological and medical sciences ; General pharmacology ; Medical sciences ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments</subject><ispartof>Drug development and industrial pharmacy, 1992, Vol.18 (1), p.93-106</ispartof><rights>1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-e70b9fdad90a20edbc14305c78c09a63e879c998812a292141d3cc881c1e7bd03</citedby><cites>FETCH-LOGICAL-c377t-e70b9fdad90a20edbc14305c78c09a63e879c998812a292141d3cc881c1e7bd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/03639049209043686$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/03639049209043686$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5078597$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Bos, C. E.</creatorcontrib><creatorcontrib>Bolhuis, G. K.</creatorcontrib><creatorcontrib>Lerk, C. F.</creatorcontrib><creatorcontrib>Duineveld, C. A.A.</creatorcontrib><title>Evaluation of modified rice starch, a new excipient for direct compression</title><title>Drug development and industrial pharmacy</title><description>Abstract
The compression characteristics of modified rice starch (PrimotabRET), a new excipient for the preparation of tablets by direct compression is evaluated. Modified rice starch is an agglomerated rice starch product. It has excellent flowing and disintegration properties. In contrast to other starch-based filler-binders, after mixing with a lubricant, the binding properties were sufficient.
Tablets containing oxazepam as a model drug were prepared with modified rice starch as unique filler-binder or with a blend of equal parts of modified rice starch and a commonly used filler-binder. The tablet properties show that modified rice starch is a useful product for the preparation of tablets by direct compression. It can be used as a unique filler-binder, or in combination with other excipients such as α-lactose monohydrate or anhydrous lactose. Combinations with microcrystalline cellulose should be avoided because of the poor flowability of the blends and the slow disintegration of the tablets.</description><subject>Biological and medical sciences</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><issn>0363-9045</issn><issn>1520-5762</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LAzEQhoMoWKs_wFsOHl3NR3ezQS8i9YuCFz0v00mWpuxulmRr7b83pSqI0MsMwzvPfLyEnHN2JTnT10wWUrOJFixFWZTFARnxXLAsV4U4JKOtniUpPyYnMS4Z40Ln-Yi8TD-gWcHgfEd9TVtvXO2socGhpXGAgItLCrSza2o_0fXOdgOtfaDGBYsDRd_2wcaY-FNyVEMT7dl3HpP3h-nb_VM2e318vr-bZSiVGjKr2FzXBoxmIJg1c-QTyXJUJTINhbSl0qh1WXIBQgs-4UYiphK5VXPD5Jjw3VwMPsZg66oProWwqTirtmZU_8xIzMWO6SEiNHWADl38BXOmylyr1Ha7a3Nd-rGFtQ-NqQbYND78MHLflps_-MJCMywQgq2WfhW65MqeG78AIEuD-Q</recordid><startdate>1992</startdate><enddate>1992</enddate><creator>Bos, C. E.</creator><creator>Bolhuis, G. K.</creator><creator>Lerk, C. F.</creator><creator>Duineveld, C. A.A.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1992</creationdate><title>Evaluation of modified rice starch, a new excipient for direct compression</title><author>Bos, C. E. ; Bolhuis, G. K. ; Lerk, C. F. ; Duineveld, C. A.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-e70b9fdad90a20edbc14305c78c09a63e879c998812a292141d3cc881c1e7bd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bos, C. E.</creatorcontrib><creatorcontrib>Bolhuis, G. K.</creatorcontrib><creatorcontrib>Lerk, C. F.</creatorcontrib><creatorcontrib>Duineveld, C. A.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Drug development and industrial pharmacy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bos, C. E.</au><au>Bolhuis, G. K.</au><au>Lerk, C. F.</au><au>Duineveld, C. A.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of modified rice starch, a new excipient for direct compression</atitle><jtitle>Drug development and industrial pharmacy</jtitle><date>1992</date><risdate>1992</risdate><volume>18</volume><issue>1</issue><spage>93</spage><epage>106</epage><pages>93-106</pages><issn>0363-9045</issn><eissn>1520-5762</eissn><abstract>Abstract
The compression characteristics of modified rice starch (PrimotabRET), a new excipient for the preparation of tablets by direct compression is evaluated. Modified rice starch is an agglomerated rice starch product. It has excellent flowing and disintegration properties. In contrast to other starch-based filler-binders, after mixing with a lubricant, the binding properties were sufficient.
Tablets containing oxazepam as a model drug were prepared with modified rice starch as unique filler-binder or with a blend of equal parts of modified rice starch and a commonly used filler-binder. The tablet properties show that modified rice starch is a useful product for the preparation of tablets by direct compression. It can be used as a unique filler-binder, or in combination with other excipients such as α-lactose monohydrate or anhydrous lactose. Combinations with microcrystalline cellulose should be avoided because of the poor flowability of the blends and the slow disintegration of the tablets.</abstract><cop>Colchester</cop><pub>Informa UK Ltd</pub><doi>10.3109/03639049209043686</doi><tpages>14</tpages></addata></record> |
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| ispartof | Drug development and industrial pharmacy, 1992, Vol.18 (1), p.93-106 |
| issn | 0363-9045 1520-5762 |
| language | eng |
| recordid | cdi_pascalfrancis_primary_5078597 |
| source | Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Biological and medical sciences General pharmacology Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments |
| title | Evaluation of modified rice starch, a new excipient for direct compression |
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