Inhibition of Protein-Kinase C in Peripheral Blood Mononuclear Cells of Patients with Systemic Lupus Erythematosus: Effect on Spontaneous Immunoglobulin Production

Systemic Lupus Erythematosus (SLE) is a multisystem disease characterized by an increase in the spontaneous secretion of immunoglobulin (Ig) molecules, many of which are autoreactive. We have previously shown (Biochem & Biophys. Res. Comm. (1989) 161: 1319-1326) that normal human peripheral bloo...

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Veröffentlicht in:	Autoimmunity (Chur, Switzerland) Switzerland), 1991, Vol.10 (3), p.227-231
Hauptverfasser:	Chong, Penny, Matzner, William I., Yamiguchi, Dean, Wallace, Daniel, Klinenberg, James R., Jordan, Stanley C.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine Adult Autoantibodies - analysis Biological and medical sciences Cells, Cultured - drug effects Female Humans Immunoglobulin G - analysis Immunoglobulin G - blood immunoglobulin production Isoquinolines - pharmacology Lupus Erythematosus, Systemic - blood Male Medical sciences Monocytes - drug effects Monocytes - enzymology Monocytes - immunology Piperazines - pharmacology Pokeweed Mitogens Protein Kinase C - antagonists & inhibitors Protein Kinase C - blood protein-kinase C Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis SLE Sulfonamides
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