Beta-blocking Potency and Selectivity of Bopindolol and Its Two Metabolites for β1-and β2-Adrenergic Receptors as Assessed by Radioligand Binding Assay

Using a radioligand binding assay, we assessed the affinity and selectivity of the antagonistic effects of bopindolol (4-(benzoyloxy-3-tert-butylaminopropyl)-2-methylindole hydrogenmalonate) and its two metabolites, (18-502, (4-(3-tert-butylamino-2-hydroxypropoxy)-2-methyl indole) and 20-785, (4-(3-...

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Veröffentlicht in:	Journal of Pharmacobio-Dynamics 1991, Vol.14(5), pp.250-255
Hauptverfasser:	SAKUMA, Noriko, TSUCHIHASHI, Hiroshi, HOSOHATA, Yoshiaki, AKASHI, Hirofumi, KINAMI, Junji, NAGATOMO, Takafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antihypertensive agents Biological and medical sciences Cardiovascular system Medical sciences Pharmacology. Drug treatments radioligand binding assay
Online-Zugang:	Volltext
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