Entrapment and Inhibition of Human Immunodeficiency Virus Proteinase by α2-Macroglobulin and Structural Changes in the Inhibitor

The inhibitory effect of α2-macroglobulin (α2M), a major plasma proteinase inhibitor, on human immunodeficiency virus (HTV) proteinase was investigated. The activity of HTV proteinase toward the Moloney murine sarcoma virus-derived gag protein (a highmolecular-mass substrate) was found to be inhibit...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 1993-06, Vol.113 (6), p.742-746
Hauptverfasser:	Athauda, Senarath B.P., Ido, Eiji, Arakawa, Hideo, Nishigai, Masaaki, Kyushiki, Hiroyuki, Yoshinaka, Yoshiyuki, Takahashi, Takayuki, Dcai, Atsushi, Tang, Jordan, Takahashi, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Biological and medical sciences Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Hydrolases
Online-Zugang:	Volltext
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