Metabolites of sodium selenite and methylated selenium compounds administered at cancer chemoprevention levels in the rat

1. The metabolism of orally-administered sodium selenite and five methylated selenium compounds was investigated in the female rat at dosages equivalent to those used in other studies for prevention of mammary cancer. Dimethyl selenide (DMSe) exhaled within 24 h following dosing was measured, along...

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Veröffentlicht in:	Xenobiotica 1993, Vol.23 (7), p.731-745
Hauptverfasser:	Vadhanavikit, S., Ip, C., Ganther, H. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - metabolism Anticarcinogenic Agents - pharmacology Anticarcinogenic Agents - urine Betaine - analogs & derivatives Betaine - metabolism Betaine - pharmacokinetics Betaine - urine Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Chemical agents Dose-Response Relationship, Drug Female Mammary Neoplasms, Experimental - prevention & control Medical sciences Methylation Organoselenium Compounds - metabolism Organoselenium Compounds - pharmacokinetics Organoselenium Compounds - urine Rats Rats, Sprague-Dawley Selenium Compounds - metabolism Selenium Compounds - pharmacology Selenium Compounds - urine Selenium Radioisotopes Sodium Selenite - metabolism Sodium Selenite - pharmacology Sodium Selenite - urine Tissue Distribution Tumors
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