The Ras Signaling Pathway Mimics Insulin Action on Glucose Transporter Translocation

Recent observations suggest that insulin increases cellular levels of activated, GTP-bound Ras protein. We tested whether the acute actions of insulin on hexose uptake and glucose-transporter redistribution to the cell surface are mimicked by activated Ras. 3T3-L1 fibroblasts expressing an activated...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1993-05, Vol.90 (10), p.4460-4464
Hauptverfasser:	Kozma, Lynn, Baltensperger, Kurt, Klarlund, Jes, Porras, Almudena, Santos, Eugenio, Czech, Michael P.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 3T3 L1 cells Adipocytes Animals Antibodies Biological and medical sciences Biological Transport Cell Membrane - metabolism Cell membranes Cell physiology Cellular biology Cultured cells Deoxyglucose - metabolism Facilitative glucose transport proteins Fibroblasts Fundamental and applied biological sciences. Psychology Glucose - metabolism In Vitro Techniques Insulin Insulin - physiology Membrane and intracellular transports Mice Molecular and cellular biology Monosaccharide Transport Proteins - metabolism Phosphatidylinositol 3-Kinases Phosphatidylinositols Phosphotransferases - metabolism Proteins Proto-Oncogene Proteins p21(ras) - physiology Receptor, Insulin - physiology Receptors Signal Transduction
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