Toxic Effects and Detection of Oxygen Free Radicals on Cultured Articular Chondrocytes Generated by Menadione

The aim of this work was to study the proliferation pathological perturbations of cultured chondrocytes in response to menadione, an oxygen free radicals producing drug. Rabbit articular chondrocytes in monolayer culture were treated with 10−5, 1.5.M−5 and 2.10−5M of menadione during three days. A d...

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Veröffentlicht in:	Free radical research 1992, Vol.17 (4), p.279-289
Hauptverfasser:	Michel, Christine, Vincent, Francoise, Duval, Christine, Poelman, Marie-Christine, Adolphe, Monique
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cartilage, Articular - cytology Cartilage, Articular - drug effects catalase Catalase - pharmacology Cell Cycle - drug effects Cell Division - drug effects Cell physiology Cells, Cultured cultured chondrocytes Effects of physical and chemical agents electron spin resonance Electron Spin Resonance Spectroscopy Flow Cytometry free radicals Fundamental and applied biological sciences. Psychology Menadione Molecular and cellular biology Rabbits Reactive Oxygen Species - analysis Vitamin E - pharmacology Vitamin K - toxicity
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