Expression and Characterization of Human FKBP52, an Immunophilin that Associates with the 90-kDa Heat Shock Protein and is a Component of Steroid Receptor Complexes

Using an FK506 affinity column to identify mammalian immunosuppressant-binding proteins, we identified an immunophilin with an apparent Mr≈ 55,000, which we have named FKBP52. We used chemically determined peptide sequence and a computerized algorithm to search GenPept, the translated GenBank data b...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-11, Vol.89 (22), p.10974-10978
Hauptverfasser:	Peattie, Debra A., Harding, Matthew W., Fleming, Mark A., DeCenzo, Maureen T., Lippke, Judith A., Livingston, David J., Benasutti, Matt
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Isomerases - genetics Amino Acid Isomerases - isolation & purification Amino Acid Isomerases - metabolism Amino Acid Sequence Analytical, structural and metabolic biochemistry Base Sequence Binding and carrier proteins Binding Sites Biochemistry Biological and medical sciences Blotting, Northern Carrier Proteins - genetics Carrier Proteins - isolation & purification Carrier Proteins - metabolism cDNA Cloning, Molecular Complementary DNA complex Escherichia coli - genetics expression FKBP52 protein Fundamental and applied biological sciences. Psychology genes Heat shock proteins Heat-Shock Proteins - genetics Heat-Shock Proteins - isolation & purification Heat-Shock Proteins - metabolism Humans Immunity (Disease) immunophilin Immunosuppressants Macromolecular Substances man Mice Molecular Sequence Data Molecular Weight nucleotide sequence Oligodeoxyribonucleotides Organ Specificity Peptidylprolyl Isomerase predictions Proteins receptors Receptors, Steroid - metabolism Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Regional identity Restriction Mapping RNA Probes Sequence Homology, Amino Acid Skeletal muscle Steroid receptors steroids Substrate specificity Tacrolimus - metabolism Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!