Peculiarities of functioning of protein-synthesizing apparatus of the hibernator ( Citellus undulatus)
Synthesis of proteins and RNA has been studied by means of labeled precursors of 14C-labeled amino acids and [ 14C]orotic acid in liver cells of hibernating, arousing, and active ground squirrels ( Citellus undulatus). The investigations indicate that cycloheximide (CHI)-inhibited protein synthesis...
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| Veröffentlicht in: | Cryobiology 1992-12, Vol.29 (6), p.679-684 |
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| container_title | Cryobiology |
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| creator | Gulevsky, A.K. Grischenko, V.I. Zagnoiko, V.I. Shchenyavsky, I.I. Ilyasova, E.N. |
| description | Synthesis of proteins and RNA has been studied by means of labeled precursors of
14C-labeled amino acids and [
14C]orotic acid in liver cells of hibernating, arousing, and active ground squirrels (
Citellus undulatus). The investigations indicate that cycloheximide (CHI)-inhibited protein synthesis in liver cells of hibernating ground squirrels may occur on preexisting polyribosomes. A low level of protein synthesis in this state results not only from the Arrhenius dependence, but also from the dissociation of polyribosomes into monosomes. During arousal there is an intensive assembly of polyribosomes. This occurs even with the inhibition of RNA synthesis by actinomycin D, testifying to the presence of a pool of iRNA in liver cells, which is necessary to activate translation. The intensity of protein synthesis in arousal is also influenced by the activation of transcription. |
| doi_str_mv | 10.1016/0011-2240(92)90071-9 |
| format | Article |
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14C-labeled amino acids and [
14C]orotic acid in liver cells of hibernating, arousing, and active ground squirrels (
Citellus undulatus). The investigations indicate that cycloheximide (CHI)-inhibited protein synthesis in liver cells of hibernating ground squirrels may occur on preexisting polyribosomes. A low level of protein synthesis in this state results not only from the Arrhenius dependence, but also from the dissociation of polyribosomes into monosomes. During arousal there is an intensive assembly of polyribosomes. This occurs even with the inhibition of RNA synthesis by actinomycin D, testifying to the presence of a pool of iRNA in liver cells, which is necessary to activate translation. The intensity of protein synthesis in arousal is also influenced by the activation of transcription.</description><identifier>ISSN: 0011-2240</identifier><identifier>EISSN: 1090-2392</identifier><identifier>DOI: 10.1016/0011-2240(92)90071-9</identifier><identifier>PMID: 1282449</identifier><identifier>CODEN: CRYBAS</identifier><language>eng</language><publisher>SAN DIEGO: Elsevier Inc</publisher><subject>Animals ; Arousal - physiology ; Biological and medical sciences ; Biology ; Cycloheximide - pharmacology ; Cytoplasm - metabolism ; Cytoplasm - ultrastructure ; Fundamental and applied biological sciences. Psychology ; Hibernation - physiology ; In Vitro Techniques ; Life Sciences & Biomedicine ; Life Sciences & Biomedicine - Other Topics ; Liver - drug effects ; Liver - metabolism ; Liver - ultrastructure ; Microscopy, Electron ; Physiology ; Protein Biosynthesis ; Ribosomes - metabolism ; RNA - biosynthesis ; Science & Technology ; Sciuridae - metabolism ; Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Cryobiology, 1992-12, Vol.29 (6), p.679-684</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>10</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wosA1992KA52800004</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c386t-602f6f50e40526010f75a8ae0ebf17bd323013162303c34871fd22488b83742a3</citedby><cites>FETCH-LOGICAL-c386t-602f6f50e40526010f75a8ae0ebf17bd323013162303c34871fd22488b83742a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0011-2240(92)90071-9$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>310,311,315,781,785,790,791,3551,23935,23936,25145,27197,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4475005$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1282449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gulevsky, A.K.</creatorcontrib><creatorcontrib>Grischenko, V.I.</creatorcontrib><creatorcontrib>Zagnoiko, V.I.</creatorcontrib><creatorcontrib>Shchenyavsky, I.I.</creatorcontrib><creatorcontrib>Ilyasova, E.N.</creatorcontrib><title>Peculiarities of functioning of protein-synthesizing apparatus of the hibernator ( Citellus undulatus)</title><title>Cryobiology</title><addtitle>CRYOBIOLOGY</addtitle><addtitle>Cryobiology</addtitle><description>Synthesis of proteins and RNA has been studied by means of labeled precursors of
14C-labeled amino acids and [
14C]orotic acid in liver cells of hibernating, arousing, and active ground squirrels (
Citellus undulatus). The investigations indicate that cycloheximide (CHI)-inhibited protein synthesis in liver cells of hibernating ground squirrels may occur on preexisting polyribosomes. A low level of protein synthesis in this state results not only from the Arrhenius dependence, but also from the dissociation of polyribosomes into monosomes. During arousal there is an intensive assembly of polyribosomes. This occurs even with the inhibition of RNA synthesis by actinomycin D, testifying to the presence of a pool of iRNA in liver cells, which is necessary to activate translation. The intensity of protein synthesis in arousal is also influenced by the activation of transcription.</description><subject>Animals</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Biology</subject><subject>Cycloheximide - pharmacology</subject><subject>Cytoplasm - metabolism</subject><subject>Cytoplasm - ultrastructure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hibernation - physiology</subject><subject>In Vitro Techniques</subject><subject>Life Sciences & Biomedicine</subject><subject>Life Sciences & Biomedicine - Other Topics</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Liver - ultrastructure</subject><subject>Microscopy, Electron</subject><subject>Physiology</subject><subject>Protein Biosynthesis</subject><subject>Ribosomes - metabolism</subject><subject>RNA - biosynthesis</subject><subject>Science & Technology</subject><subject>Sciuridae - metabolism</subject><subject>Thermoregulation. Hibernation. Estivation. 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Psychology</topic><topic>Hibernation - physiology</topic><topic>In Vitro Techniques</topic><topic>Life Sciences & Biomedicine</topic><topic>Life Sciences & Biomedicine - Other Topics</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Liver - ultrastructure</topic><topic>Microscopy, Electron</topic><topic>Physiology</topic><topic>Protein Biosynthesis</topic><topic>Ribosomes - metabolism</topic><topic>RNA - biosynthesis</topic><topic>Science & Technology</topic><topic>Sciuridae - metabolism</topic><topic>Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gulevsky, A.K.</creatorcontrib><creatorcontrib>Grischenko, V.I.</creatorcontrib><creatorcontrib>Zagnoiko, V.I.</creatorcontrib><creatorcontrib>Shchenyavsky, I.I.</creatorcontrib><creatorcontrib>Ilyasova, E.N.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 1992</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cryobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gulevsky, A.K.</au><au>Grischenko, V.I.</au><au>Zagnoiko, V.I.</au><au>Shchenyavsky, I.I.</au><au>Ilyasova, E.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peculiarities of functioning of protein-synthesizing apparatus of the hibernator ( Citellus undulatus)</atitle><jtitle>Cryobiology</jtitle><stitle>CRYOBIOLOGY</stitle><addtitle>Cryobiology</addtitle><date>1992-12-01</date><risdate>1992</risdate><volume>29</volume><issue>6</issue><spage>679</spage><epage>684</epage><pages>679-684</pages><issn>0011-2240</issn><eissn>1090-2392</eissn><coden>CRYBAS</coden><abstract>Synthesis of proteins and RNA has been studied by means of labeled precursors of
14C-labeled amino acids and [
14C]orotic acid in liver cells of hibernating, arousing, and active ground squirrels (
Citellus undulatus). The investigations indicate that cycloheximide (CHI)-inhibited protein synthesis in liver cells of hibernating ground squirrels may occur on preexisting polyribosomes. A low level of protein synthesis in this state results not only from the Arrhenius dependence, but also from the dissociation of polyribosomes into monosomes. During arousal there is an intensive assembly of polyribosomes. This occurs even with the inhibition of RNA synthesis by actinomycin D, testifying to the presence of a pool of iRNA in liver cells, which is necessary to activate translation. The intensity of protein synthesis in arousal is also influenced by the activation of transcription.</abstract><cop>SAN DIEGO</cop><pub>Elsevier Inc</pub><pmid>1282449</pmid><doi>10.1016/0011-2240(92)90071-9</doi><tpages>6</tpages></addata></record> |
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| ispartof | Cryobiology, 1992-12, Vol.29 (6), p.679-684 |
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| source | Web of Science - Science Citation Index Expanded - 1992<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Arousal - physiology Biological and medical sciences Biology Cycloheximide - pharmacology Cytoplasm - metabolism Cytoplasm - ultrastructure Fundamental and applied biological sciences. Psychology Hibernation - physiology In Vitro Techniques Life Sciences & Biomedicine Life Sciences & Biomedicine - Other Topics Liver - drug effects Liver - metabolism Liver - ultrastructure Microscopy, Electron Physiology Protein Biosynthesis Ribosomes - metabolism RNA - biosynthesis Science & Technology Sciuridae - metabolism Thermoregulation. Hibernation. Estivation. Ecophysiology and environmental effects Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Peculiarities of functioning of protein-synthesizing apparatus of the hibernator ( Citellus undulatus) |
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