Ser-752 → Pro Mutation in the Cytoplasmic Domain of Integrin β3Subunit and Defective Activation of Platelet Integrin αIIbβ3(Glycoprotein IIb-IIIa) in a Variant of Glanzmann Thrombasthenia

Integrins are membrane receptors which mediate cell-cell or cell-matrix adhesion. Integrin αIIbβ3(glycoprotein IIb-IIIa) acts as a fibrinogen receptor of platelets and mediates platelet aggregation. Platelet activation is required for αIIbβ3to shift from noncompetent to competent for binding soluble...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1992-11, Vol.89 (21), p.10169-10173
Hauptverfasser:	Chen, Yi-Ping, Djaffar, Isabelle, Pidard, Dominique, Steiner, Beat, Cieutat, Anne-Marie, Caen, Jacques P., Rosa, Jean-Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Biological and medical sciences DNA Gels Genetic mutation Hematologic and hematopoietic diseases Integrins Medical sciences Messenger RNA Platelet diseases and coagulopathies Platelets Polymerase chain reaction RNA Thrombasthenia
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